Networks of companies, research laboratories and universities provide benefits for innovation activities. Some success factors are bound to particular characteristics of a region. This is the case for industries based on craftsmanship such as the watch industry or the machine building industry.The latter is one of the most innovative in Switzerland. However, for successful innovationnationwide or even worldwide contacts play an increasingly important role, although there aremajor differences between technologies and sectors. It is shown that business success through innovation in biotechnology or medical technology relies not only on a strong scientific base within the home region but also on intensive contacts with the major centers of competence worldwide.The article identifies different types of innovative regions in Switzerland with different innovation strategies, though some may overlap. Their activities are supported by the openness and international connections of Switzerland as well as its high degree of internationalization.