Woodruff, Kristina; Fidalgo, Luis M; Gobaa, Samy; Lutolf, Matthias P; Maerkl, Sebastian J (2013). Live Mammalian Cell Arrays. Nature Methods, 10(6):550-552.
High-content assays have the potential to drastically increase throughput in cell biology and drug discovery, but handling and culturing large libraries of cells such as primary tumor or cancer cell lines requires expensive, dedicated robotic equipment. We have developed a simple, yet powerful method that uses contact spotting to generate highdensity nanowell arrays of live mammalian cells for the culture and interrogation of cell libraries.
High-content assays have the potential to drastically increase throughput in cell biology and drug discovery, but handling and culturing large libraries of cells such as primary tumor or cancer cell lines requires expensive, dedicated robotic equipment. We have developed a simple, yet powerful method that uses contact spotting to generate highdensity nanowell arrays of live mammalian cells for the culture and interrogation of cell libraries.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > DynamiX Special Collections > SystemsX.ch > Research, Technology and Development Projects |
| Dewey Decimal Classification: | 570 Life sciences; biology |
| Scopus Subject Areas: | Life Sciences > Biotechnology
Life Sciences > Biochemistry Life Sciences > Molecular Biology Life Sciences > Cell Biology |
| Language: | English |
| Date: | June 2013 |
| Deposited On: | 22 Jun 2013 13:32 |
| Last Modified: | 24 Jan 2022 01:05 |
| Publisher: | Nature Publishing Group |
| ISSN: | 1548-7091 |
| OA Status: | Green |
| Publisher DOI: | https://doi.org/10.1038/NMETH.2473 |
Woodruff, Kristina