Smirnova, E; Toueille, M; Markkanen, E; Hübscher, U (2005). The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery. Biochemical Journal, 389(1):13-17.
The human checkpoint sensor and alternative clamp Rad9-Rad1-Hus1 can interact with and specifically stimulate DNA ligase I. The very recently described interactions of Rad9-Rad1-Hus1 with MutY DNA glycosylase, DNA polymerase beta and Flap endonuclease 1 now complete our view that the long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA.
The human checkpoint sensor and alternative clamp Rad9-Rad1-Hus1 can interact with and specifically stimulate DNA ligase I. The very recently described interactions of Rad9-Rad1-Hus1 with MutY DNA glycosylase, DNA polymerase beta and Flap endonuclease 1 now complete our view that the long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA.
| Item Type: | Journal Article, refereed |
|---|---|
| Communities & Collections: | 05 Vetsuisse Faculty > Department of Molecular Mechanisms of Disease
07 Faculty of Science > Department of Molecular Mechanisms of Disease |
| Dewey Decimal Classification: | 570 Life sciences; biology |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Biology Life Sciences > Cell Biology |
| Language: | English |
| Date: | 1 July 2005 |
| Deposited On: | 11 Feb 2008 12:18 |
| Last Modified: | 23 Jan 2022 08:37 |
| Publisher: | Portland Press |
| ISSN: | 0264-6021 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1042/BJ20050211 |
| PubMed ID: | 15871698 |
Smirnova, E