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An externally modulated, noise-driven switch for the regulation of SPI1 in Salmonella enterica serovar Typhimurium

Bailly-Bechet, Marc; Benecke, Arndt; Hardt, Wolf Dietrich; Lanza, Valentina; Sturm, Alexander; Zecchina, Riccardo (2011). An externally modulated, noise-driven switch for the regulation of SPI1 in Salmonella enterica serovar Typhimurium. Journal of Mathematical Biology, 63(4):637-662.

Abstract

In this work we consider the regulation system present on the SPI1 pathogenicity island of Salmonella enterica serovar Typhimurium. It is well-known that HilA is the central regulator in the overall scheme of SPI1 regulation and directly binds to virulence operons and activates their expression. The regulation of the expression of HilA is via a complex feed-forward loop involving three transcriptional activators: HilC, HilD and RtsA, and the negative regulator HilE. Our aim is to model this regulation network and study its dynamical behavior. We show that this regulatory system can display a bistable behavior relevant to the biology of Salmonella, and that noise can be a driving force in this system.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > InfectX
Special Collections > SystemsX.ch > Research, Technology and Development Projects
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Physical Sciences > Modeling and Simulation
Life Sciences > Agricultural and Biological Sciences (miscellaneous)
Physical Sciences > Applied Mathematics
Language:English
Date:2011
Deposited On:19 Aug 2013 13:59
Last Modified:27 Oct 2024 04:51
Publisher:Springer
ISSN:0303-6812
Additional Information:The final publication is available at Springer via http://dx.doi.org/10.1007/s00285-010-0385-1
OA Status:Green
Publisher DOI:https://doi.org/10.1007/s00285-010-0385-1
PubMed ID:21107576
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