Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Migration von ZORA auf die Software DSpace

ZORA will change to a new software on 8th September 2025. Please note: deadline for new submissions is 21th July 2025!

Information & dates for training courses can be found here: Information on Software Migration.

A New 2H-Azirin-3-amine as a Synthon for α-Methyl Glutamate

Hilty, Florentine M; Brun, Kathrin A; Heimgartner, Heinz (2004). A New 2H-Azirin-3-amine as a Synthon for α-Methyl Glutamate. Helvetica Chimica Acta, 87(10):2539-2548.

Abstract

The synthesis of a novel 2,2-disubstituted 2H-azirin-3-amine 10 as a building block for racemic Glu(2Me) is described. This synthon contains an ester group in the side chain. The reaction of 10 with thiobenzoic S-acid and the amino acid Z-Val-OH yielded the racemic monothiodiamide 17 and the dipeptide 18 as a mixture of diastereoisomers, respectively (Scheme 2). From 18, each of the protecting groups was removed selectively (Scheme 3).

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Catalysis
Life Sciences > Biochemistry
Life Sciences > Drug Discovery
Physical Sciences > Physical and Theoretical Chemistry
Physical Sciences > Organic Chemistry
Physical Sciences > Inorganic Chemistry
Uncontrolled Keywords:Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Biochemistry, Drug Discovery, Catalysis
Language:English
Date:2004
Deposited On:13 Aug 2013 15:03
Last Modified:09 Jun 2025 01:37
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0018-019X
Funders:Swiss National Science Foundation, F. Hoffmann-La Roche AG, Basel, Stiftung für wissenschaftliche Forschung an der Universität Zürich, Prof. Dr. Hans E. Schmid-Stiftung
OA Status:Green
Publisher DOI:https://doi.org/10.1002/hlca.200490226
Project Information:
  • Funder: SNSF
  • Grant ID:
  • Project Title: Swiss National Science Foundation
  • Funder:
  • Grant ID:
  • Project Title: F. Hoffmann-La Roche AG, Basel
  • Funder:
  • Grant ID:
  • Project Title: Stiftung für wissenschaftliche Forschung an der Universität Zürich
  • Funder:
  • Grant ID:
  • Project Title: Prof. Dr. Hans E. Schmid-Stiftung

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
8 citations in Web of Science®
9 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

114 downloads since deposited on 13 Aug 2013
17 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications