Abstract
The synthesis of a novel 2,2-disubstituted 2H-azirin-3-amine 10 as a building block for racemic Glu(2Me) is described. This synthon contains an ester group in the side chain. The reaction of 10 with thiobenzoic S-acid and the amino acid Z-Val-OH yielded the racemic monothiodiamide 17 and the dipeptide 18 as a mixture of diastereoisomers, respectively (Scheme 2). From 18, each of the protecting groups was removed selectively (Scheme 3).
Item Type: | Journal Article, refereed, original work |
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Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
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Dewey Decimal Classification: | 540 Chemistry |
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Scopus Subject Areas: | Physical Sciences > Catalysis
Life Sciences > Biochemistry
Life Sciences > Drug Discovery
Physical Sciences > Physical and Theoretical Chemistry
Physical Sciences > Organic Chemistry
Physical Sciences > Inorganic Chemistry |
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Uncontrolled Keywords: | Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Biochemistry, Drug Discovery, Catalysis |
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Language: | English |
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Date: | 2004 |
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Deposited On: | 13 Aug 2013 15:03 |
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Last Modified: | 09 Jun 2025 01:37 |
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Publisher: | Wiley-Blackwell Publishing, Inc. |
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ISSN: | 0018-019X |
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Funders: | Swiss National Science Foundation, F. Hoffmann-La Roche AG, Basel, Stiftung für wissenschaftliche Forschung an der Universität Zürich, Prof. Dr. Hans E. Schmid-Stiftung |
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OA Status: | Green |
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Publisher DOI: | https://doi.org/10.1002/hlca.200490226 |
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Project Information: | - Funder: SNSF
- Grant ID:
- Project Title: Swiss National Science Foundation
- Funder:
- Grant ID:
- Project Title: F. Hoffmann-La Roche AG, Basel
- Funder:
- Grant ID:
- Project Title: Stiftung für wissenschaftliche Forschung an der Universität Zürich
- Funder:
- Grant ID:
- Project Title: Prof. Dr. Hans E. Schmid-Stiftung
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