Abstract
Aib-containing peptides have been synthesized from the N- to the C-terminus by the ‘‘azirine/oxazolone method’’ under solid-phase conditions. In this new and convenient method for the synthesis of sterically demanding peptides on solid phase, 2H-azirine-3-amines are used to introduce aminoisobutyric acid, an α,α-disubstituted α-amino acid, into the peptide without the need for further reagents. Segments of naturally occurring peptaibols have been prepared by this method.