Purpose: To report the 12-month outcomes of 1,140 treatment-naïve eyes with exudative age-related macular degeneration (wet AMD) who were treated for 12 months with intravitreal anti-VEGF drugs in routine clinical practice. Methods: Index visit characteristics, such as lesion type and size, visual acuity (VA in logMAR [Logarithm of the Minimal Angle of Resolution] letters), as well as treatments, outcomes (VA, lesion activity status) and ocular adverse events were recorded in a prospectively designed electronic database. Index visit characteristics associated with the 12-month VA outcome were identified using mixed effects linear regression. Results: Mean change in VA in the cohort after 12 months was +4.7 logMAR letters (95%CI: 3.4 to 6.1) with a mean of 7.0 injections. No significant difference was found in change in VA or number of injections by type or size of the lesion. Median time to inactivation of lesions was 194 days. VA at the index visit was the strongest predictor for the 12-month outcomes. Infectious endophthalmitis occurred in 2 cases, retinal detachment in 1 case from a total of 9,162 injections. Conclusions: These findings indicate that VEGF inhibitors can achieve reasonably good outcomes for wet AMD when used in routine clinical practice.