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Blanca, G; Baldanti, F; Paolucci, S; Skoblov, A Y; Victorova, L; Hübscher, U; Gerna, G; Spadari, S; Maga, G (2003). Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. Journal of Biological Chemistry, 278(18):15469-15472.
Recombinant HIV-1 reverse transcriptase (RT) carrying non-nucleoside inhibitors (NNRTIs) resistance mutation at codon 181 showed reduced incorporation and high efficiency of phosphorolytic removal of stavudine, a nucleoside RT inhibitor. These results reveal a new mechanism for cross-resistance between different classes of HIV-1 RT inhibitors.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Department of Molecular Mechanisms of Disease
07 Faculty of Science > Department of Molecular Mechanisms of Disease |
| Dewey Decimal Classification: | 570 Life sciences; biology |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Biology Life Sciences > Cell Biology |
| Language: | English |
| Date: | 2 May 2003 |
| Deposited On: | 11 Feb 2008 12:18 |
| Last Modified: | 01 May 2025 01:35 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| ISSN: | 0021-9258 |
| OA Status: | Hybrid |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1074/jbc.C300022200 |
| PubMed ID: | 12601008 |
Blanca, G