Sannomiya, T; Hafner, C; Voros, J (2008). In situ sensing of single binding events by localized surface plasmon resonance. Nano Letters, 8(10):3450-3455.
Single binding events of nanoparticle-labeled DNA strands were detected as stepwise peak shifts in localized surface plasmon resonance by single particle measurement. We confirmed the number of binding events by observing label particles by scanning electron microscopy. Our simulation based on a multiple multipole program showed that the peak shift is dependent on interparticle gap size and binding position. The experimental peak shift distribution was also reproduced by simulation.
Single binding events of nanoparticle-labeled DNA strands were detected as stepwise peak shifts in localized surface plasmon resonance by single particle measurement. We confirmed the number of binding events by observing label particles by scanning electron microscopy. Our simulation based on a multiple multipole program showed that the peak shift is dependent on interparticle gap size and binding position. The experimental peak shift distribution was also reproduced by simulation.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute of Biomedical Engineering |
| Dewey Decimal Classification: | 170 Ethics
610 Medicine & health |
| Scopus Subject Areas: | Physical Sciences > Bioengineering
Physical Sciences > General Chemistry Physical Sciences > General Materials Science Physical Sciences > Condensed Matter Physics Physical Sciences > Mechanical Engineering |
| Language: | English |
| Date: | 2008 |
| Deposited On: | 16 Dec 2008 13:07 |
| Last Modified: | 23 Jan 2022 12:44 |
| Publisher: | American Chemical Society |
| ISSN: | 1530-6984 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1021/nl802317d |
| PubMed ID: | 18767880 |
Sannomiya, T