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The calcium-sensing receptor directly regulates proximal tubular functions


Wagner, Carsten A The calcium-sensing receptor directly regulates proximal tubular functions. Edited by: Wagner, Carsten Alexander (2013). Kidney Int. 2013: Nature Publishing Group.

Abstract

Capasso et al. show a role of the calcium-sensing receptor (CaSR) in enhancing proximal tubular fluid absorption and urinary acidification by stimulation of luminal Na(+)/H(+) exchanger (NHE) activity. NHE3 is required for sodium and fluid absorption, and its activity is coupled to passive reabsorption of a major fraction of calcium through the paracellular route. These data shed new light on the regulation of the kidney by the CaSR and whether it directly affects proximal tubular functions.

Abstract

Capasso et al. show a role of the calcium-sensing receptor (CaSR) in enhancing proximal tubular fluid absorption and urinary acidification by stimulation of luminal Na(+)/H(+) exchanger (NHE) activity. NHE3 is required for sodium and fluid absorption, and its activity is coupled to passive reabsorption of a major fraction of calcium through the paracellular route. These data shed new light on the regulation of the kidney by the CaSR and whether it directly affects proximal tubular functions.

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Additional indexing

Item Type:Edited Scientific Work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:August 2013
Deposited On:19 Sep 2013 11:24
Last Modified:01 Aug 2018 07:19
Publisher:Nature Publishing Group
Volume:84
ISSN:0085-2538
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1038/ki.2013.128
PubMed ID:23903415

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