Header

UZH-Logo

Maintenance Infos

Effects of valve geometry and tissue anisotropy on the radial stretch and coaptation area of tissue-engineered heart valves


Loerakker, S; Argento, G; Oomens, C W J; Baaijens, F P T (2013). Effects of valve geometry and tissue anisotropy on the radial stretch and coaptation area of tissue-engineered heart valves. Journal of Biomechanics, 46(11):1792-1800.

Abstract

Tissue engineering represents a promising technique to overcome the limitations of the current valve replacements, since it allows for creating living autologous heart valves that have the potential to grow and remodel. However, also this approach still faces a number of challenges. One particular problem is regurgitation, caused by cell-mediated tissue retraction or the mismatch in geometrical and material properties between tissue-engineered heart valves (TEHVs) and their native counterparts. The goal of the present study was to assess the influence of valve geometry and tissue anisotropy on the deformation profile and closed configuration of TEHVs. To achieve this aim, a range of finite element models incorporating different valve shapes was developed, and the constitutive behavior of the tissue was modeled using an established computational framework, where the degree of anisotropy was varied between values representative of TEHVs and native valves. The results of this study suggest that valve geometry and tissue anisotropy are both important to maximize the radial strains and thereby the coaptation area. Additionally, the minimum degree of anisotropy that is required to obtain positive radial strains was shown to depend on the valve shape and the pressure to which the valves are exposed. Exposure to pulmonary diastolic pressure only yielded positive radial strains if the anisotropy was comparable to the native situation, whereas considerably less anisotropy was required if the valves were exposed to aortic diastolic pressure.

Abstract

Tissue engineering represents a promising technique to overcome the limitations of the current valve replacements, since it allows for creating living autologous heart valves that have the potential to grow and remodel. However, also this approach still faces a number of challenges. One particular problem is regurgitation, caused by cell-mediated tissue retraction or the mismatch in geometrical and material properties between tissue-engineered heart valves (TEHVs) and their native counterparts. The goal of the present study was to assess the influence of valve geometry and tissue anisotropy on the deformation profile and closed configuration of TEHVs. To achieve this aim, a range of finite element models incorporating different valve shapes was developed, and the constitutive behavior of the tissue was modeled using an established computational framework, where the degree of anisotropy was varied between values representative of TEHVs and native valves. The results of this study suggest that valve geometry and tissue anisotropy are both important to maximize the radial strains and thereby the coaptation area. Additionally, the minimum degree of anisotropy that is required to obtain positive radial strains was shown to depend on the valve shape and the pressure to which the valves are exposed. Exposure to pulmonary diastolic pressure only yielded positive radial strains if the anisotropy was comparable to the native situation, whereas considerably less anisotropy was required if the valves were exposed to aortic diastolic pressure.

Statistics

Citations

Dimensions.ai Metrics
26 citations in Web of Science®
27 citations in Scopus®
29 citations in Microsoft Academic
Google Scholar™

Altmetrics

Downloads

122 downloads since deposited on 17 Oct 2013
29 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:17 Oct 2013 11:04
Last Modified:17 Feb 2018 18:38
Publisher:Elsevier
ISSN:0021-9290
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.jbiomech.2013.05.015
PubMed ID:23786664
Project Information:
  • : FunderFP7
  • : Grant ID242008
  • : Project TitleLIFEVALVE - Living autologous heart valves for minimally invasive implantable procedures

Download

Download PDF  'Effects of valve geometry and tissue anisotropy on the radial stretch and coaptation area of tissue-engineered heart valves'.
Preview
Content: Accepted Version
Filetype: PDF
Size: 3MB
View at publisher