The Riparian Soil Model (RSM) of Brovelli et al. (2012) was applied to study soil nutrient turnover in a revitalized section of the Thur River, North-East Switzerland. In the present work, the model was calibrated on field experimental data, and satisfactorily reproduced soil respiration, organic matter stocks and inorganic nitrogen fluxes. Calibrated rates were in good agreement with the ranges reported in the literature. The main discrepancies between model and observations were for dissolved organic carbon. The sensitivity of the model to environmental factors was also analyzed. Soil temperature was the most influential factor at daily and seasonal scales while effects of soil moisture were weak overall. The ecosystem sensitivity to temperature changes was quantified using the Q10 index. The seasonal behavior observed was related to the influence of other forcing factors and to the different state (density and activity) of the microbial biomass pool during the year. Environmental factors influencing microbial decomposition, such as the C:N ratio and litter input rate, showed intermediate sensitivity. Since these parameters are tightly linked to the vegetation type, the analysis highlighted the effect of the aboveground ecosystem on soil functioning.