Header

UZH-Logo

Maintenance Infos

DMSO-Mediated ligand dissociation: renaissance for biological activity of n-heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates


Patra, Malay; Joshi, Tanmaya; Pierroz, Vanessa; Ingram, Katrin; Kaiser, Marcel; Ferrari, Stefano; Spingler, Bernhard; Keiser, Jennifer; Gasser, Gilles (2013). DMSO-Mediated ligand dissociation: renaissance for biological activity of n-heterocyclic-[Ru(η(6) -arene)Cl2 ] Drug Candidates. Chemistry - A European Journal:14768-14772.

Abstract

Slipped under the radar? (1) H NMR spectroscopic examination revealed that [Ru(η(6) -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo ligand exchange reaction in DMSO, a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study stability in DMSO before reporting on the biological activity of such type of complexes.

Abstract

Slipped under the radar? (1) H NMR spectroscopic examination revealed that [Ru(η(6) -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo ligand exchange reaction in DMSO, a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study stability in DMSO before reporting on the biological activity of such type of complexes.

Statistics

Citations

Dimensions.ai Metrics
67 citations in Web of Science®
70 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 14 Nov 2013
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Molecular Cancer Research
07 Faculty of Science > Institute of Molecular Cancer Research

07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:570 Life sciences; biology
540 Chemistry
Uncontrolled Keywords:General Chemistry
Language:English
Date:2013
Deposited On:14 Nov 2013 16:05
Last Modified:18 Aug 2018 12:07
Publisher:Wiley-VCH Verlag Berlin
ISSN:0947-6539
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/chem.201303341
PubMed ID:24123460
Project Information:
  • : FunderSNSF
  • : Grant IDPP00P2_133568
  • : Project TitleCaged Metal Complexes as Tools in Inorganic Chemical Biology

Download