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Electrochemical control of the enzymatic polymerization of peg hydrogels: formation of spatially controlled biological microenvironments


Milleret, Vincent; Simona, Benjamin R; Lienemann, Philipp S; Vörös, János; Ehrbar, Martin (2014). Electrochemical control of the enzymatic polymerization of peg hydrogels: formation of spatially controlled biological microenvironments. Advanced Healthcare Materials, 3(4):508-514.

Abstract

Control of pH gradient profile at the electrode-electrolyte interfaces allows the control of the enzymatic PEG-hydrogel polymerization. By tuning the solution pH, buffer capacity, and the applied current, the extent of the local inhibition and confinement of the Factor XIII-mediated polymerization of PEG are controlled. This technology opens new perspectives for the production of 3D-structured biological microenvironments.

Abstract

Control of pH gradient profile at the electrode-electrolyte interfaces allows the control of the enzymatic PEG-hydrogel polymerization. By tuning the solution pH, buffer capacity, and the applied current, the extent of the local inhibition and confinement of the Factor XIII-mediated polymerization of PEG are controlled. This technology opens new perspectives for the production of 3D-structured biological microenvironments.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Uncontrolled Keywords:Pharmaceutical Science, Biomaterials, Biomedical Engineering
Language:English
Date:2014
Deposited On:22 Nov 2013 15:52
Last Modified:18 Aug 2018 12:17
Publisher:Wiley-Blackwell
ISSN:2192-2640
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/adhm.201300479
PubMed ID:24574303

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