Abstract
At 0° in MeCN, 2,2-disubstituted 3-amino-2H-azirines 1 and 4,4-disubstituted 1,2-thiazetidin-3-one 1,1-dioxides 7 react smoothly to give 1,2,5-thiadiazepin-6-one 1,1-dioxides of type 8 (Scheme 2). The reaction mechanism of this regiospecific ring enlargement to seven-membered heterocycles follows previously described pathways. The structures of 7a and 8h were established by X-ray crystallography (see Figs. I and 2).
Item Type: | Journal Article, refereed, original work |
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Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
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Dewey Decimal Classification: | 540 Chemistry |
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Scopus Subject Areas: | Physical Sciences > Catalysis
Life Sciences > Biochemistry
Life Sciences > Drug Discovery
Physical Sciences > Physical and Theoretical Chemistry
Physical Sciences > Organic Chemistry
Physical Sciences > Inorganic Chemistry |
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Uncontrolled Keywords: | Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Biochemistry, Drug Discovery, Catalysis |
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Language: | English |
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Date: | 1996 |
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Deposited On: | 25 Nov 2013 08:01 |
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Last Modified: | 09 Jun 2025 01:41 |
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Publisher: | Wiley-Blackwell Publishing, Inc. |
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ISSN: | 0018-019X |
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Funders: | Swiss National Science Foundation, F. Hoffmann-La Roche AG, Basel |
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OA Status: | Closed |
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Publisher DOI: | https://doi.org/10.1002/hlca.19960790803 |
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Project Information: | - Funder: SNSF
- Grant ID:
- Project Title: Swiss National Science Foundation
- Funder:
- Grant ID:
- Project Title: F. Hoffmann-La Roche AG, Basel
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