Phongtongpasuk, S; Paulus, S; Schnabl, J; Sigel, Roland K O; Spingler, Bernhard; Hannon, M J; Freisinger, Eva (2013). Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction. Angewandte Chemie Internationale Edition, 52(44):11513-11516.
Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in π-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder.
Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in π-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Scopus Subject Areas: | Physical Sciences > Catalysis
Physical Sciences > General Chemistry |
| Uncontrolled Keywords: | General Chemistry, Catalysis |
| Language: | English |
| Date: | 2013 |
| Deposited On: | 03 Feb 2014 13:46 |
| Last Modified: | 24 Jan 2022 02:56 |
| Publisher: | Wiley-VCH Verlag |
| ISSN: | 1433-7851 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1002/anie.201305079 |
Phongtongpasuk, S