Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Simulating cortical development as a self constructing process: A novel multi-scale approach combining molecular and physical aspects

Zubler, Frederic; Hauri, Andreas; Pfister, Sabina; Bauer, Roman; Anderson, John C; Whatley, Adrian M; Douglas, Rodney J (2013). Simulating cortical development as a self constructing process: A novel multi-scale approach combining molecular and physical aspects. PLoS Computational Biology, 9(8):e1003173.

Abstract

Current models of embryological development focus on intracellular processes such as gene expression and protein networks, rather than on the complex relationship between subcellular processes and the collective cellular organization these processes support. We have explored this collective behavior in the context of neocortical development, by modeling the expansion of a small number of progenitor cells into a laminated cortex with layer and cell type specific projections. The developmental process is steered by a formal language analogous to genomic instructions, and takes place in a physically realistic three-dimensional environment. A common genome inserted into individual cells control their individual behaviors, and thereby gives rise to collective developmental sequences in a biologically plausible manner. The simulation begins with a single progenitor cell containing the artificial genome. This progenitor then gives rise through a lineage of offspring to distinct populations of neuronal precursors that migrate to form the cortical laminae. The precursors differentiate by extending dendrites and axons, which reproduce the experimentally determined branching patterns of a number of different neuronal cell types observed in the cat visual cortex. This result is the first comprehensive demonstration of the principles of self-construction whereby the cortical architecture develops. In addition, our model makes several testable predictions concerning cell migration and branching mechanisms.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Neuroinformatics
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Ecology, Evolution, Behavior and Systematics
Physical Sciences > Modeling and Simulation
Physical Sciences > Ecology
Life Sciences > Molecular Biology
Life Sciences > Genetics
Life Sciences > Cellular and Molecular Neuroscience
Physical Sciences > Computational Theory and Mathematics
Language:English
Date:2013
Deposited On:12 Feb 2014 16:33
Last Modified:10 Nov 2024 02:39
Publisher:Public Library of Science (PLoS)
Series Name:PLoS Computational Biology
Number of Pages:1
ISSN:1553-734X
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1371/journal.pcbi.1003173
PubMed ID:23966845
Download PDF  'Simulating cortical development as a self constructing process: A novel multi-scale approach combining molecular and physical aspects'.
Preview
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
23 citations in Web of Science®
21 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

86 downloads since deposited on 12 Feb 2014
3 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications