Amylin/CGRP

Lutz, T A (2013). Amylin/CGRP. In: Kastin, Abba. Handbook of Biologically Active Peptides (Second Edition). Elsevier: Academic Press, 1049-1056.

Abstract

This chapter focuses on the anorectic action of the pancreatic hormone amylin and the structurally related peptide calcitonin-gene related peptide (CGRP). Both peptides when given peripherally or centrally produce potent anorectic effects and delay gastric emptying. The anorectic action of CGRP seems to parallel amylin’s effect on eating in many aspects; however, in this chapter, more emphasis will be put on the effects of amylin on eating because amylin’s effects may be of physiological relevance but this is less clear in the case of CGRP. Other effects of CGRP are mentioned in other chapters of this book.

Abstract

This chapter focuses on the anorectic action of the pancreatic hormone amylin and the structurally related peptide calcitonin-gene related peptide (CGRP). Both peptides when given peripherally or centrally produce potent anorectic effects and delay gastric emptying. The anorectic action of CGRP seems to parallel amylin’s effect on eating in many aspects; however, in this chapter, more emphasis will be put on the effects of amylin on eating because amylin’s effects may be of physiological relevance but this is less clear in the case of CGRP. Other effects of CGRP are mentioned in other chapters of this book.

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