Header

UZH-Logo

Maintenance Infos

dMyc transforms cells into super-competitors.


Moreno, E; Basler, K (2004). dMyc transforms cells into super-competitors. Cell, 117(1):117-129.

Abstract

Overexpression of myc protooncogenes has been implicated in the genesis of many human tumors. Myc proteins seem to regulate diverse biological processes, but their role in tumorigenesis remains enigmatic. Here we use Drosophila imaginal discs to mimic situations in which cells with unequal levels of Myc protein are apposed and show that this invariably elicits a win/lose situation reminiscent of cell competition; cells with lower levels of dMyc are eliminated by apoptosis whereas cells with higher levels of dMyc over-proliferate. We find that this competitive behavior correlates with, and can be corrected by, the activation of the BMP/Dpp survival signaling pathway. Hence the heritable increase in dMyc levels causes cells to behave as "super-competitors" and reveals a novel mode of clonal expansion that causes, but also relies on, the killing of surrounding cells.

Abstract

Overexpression of myc protooncogenes has been implicated in the genesis of many human tumors. Myc proteins seem to regulate diverse biological processes, but their role in tumorigenesis remains enigmatic. Here we use Drosophila imaginal discs to mimic situations in which cells with unequal levels of Myc protein are apposed and show that this invariably elicits a win/lose situation reminiscent of cell competition; cells with lower levels of dMyc are eliminated by apoptosis whereas cells with higher levels of dMyc over-proliferate. We find that this competitive behavior correlates with, and can be corrected by, the activation of the BMP/Dpp survival signaling pathway. Hence the heritable increase in dMyc levels causes cells to behave as "super-competitors" and reveals a novel mode of clonal expansion that causes, but also relies on, the killing of surrounding cells.

Statistics

Citations

Dimensions.ai Metrics
387 citations in Web of Science®
411 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

164 downloads since deposited on 11 Feb 2008
44 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > General Biochemistry, Genetics and Molecular Biology
Language:English
Date:2 April 2004
Deposited On:11 Feb 2008 12:19
Last Modified:13 Dec 2020 06:01
Publisher:Elsevier
ISSN:0092-8674
OA Status:Green
Publisher DOI:https://doi.org/10.1016/S0092-8674(04)00262-4
PubMed ID:15066287

Download

Green Open Access

Download PDF  'dMyc transforms cells into super-competitors.'.
Preview
Filetype: PDF
Size: 1MB
View at publisher