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Sleep deprivation in depression: stabilizing anti-depressant effect by repetitive transcranial magnet stimulation


Eichhammer, P; Kharraz, A; Wiegand, R; Langguth, B; Frick, Ulrich; Aigner, J M; Hajak, G (2002). Sleep deprivation in depression: stabilizing anti-depressant effect by repetitive transcranial magnet stimulation. Life Sciences, 70:1741-1749.

Abstract

Partial sleep deprivation (PSD) has a profound and rapid effect on depressed mood. However, the transient antidepressant effect of PSD - most patients relapse after one night of recovery sleep—is limiting the clinical use of this method. Using a controlled, balanced parallel design we studied, whether repetitive transcranial magnetic stimulation (rTMS) applied in the morning after PSD is able to prevent this relapse. 20 PSD responders were randomly assigned to receive either active or sham stimulation during the following 4 days after PSD. Active stimulation prolonged significantly (p<0.001) the antidepressant effect of PSD up to 4 days. This finding indicates that rTMS is an efficacious method to prevent relapse after PSD.

Abstract

Partial sleep deprivation (PSD) has a profound and rapid effect on depressed mood. However, the transient antidepressant effect of PSD - most patients relapse after one night of recovery sleep—is limiting the clinical use of this method. Using a controlled, balanced parallel design we studied, whether repetitive transcranial magnetic stimulation (rTMS) applied in the morning after PSD is able to prevent this relapse. 20 PSD responders were randomly assigned to receive either active or sham stimulation during the following 4 days after PSD. Active stimulation prolonged significantly (p<0.001) the antidepressant effect of PSD up to 4 days. This finding indicates that rTMS is an efficacious method to prevent relapse after PSD.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Swiss Research Institute for Public Health and Addiction
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Biochemistry, Genetics and Molecular Biology
Life Sciences > General Pharmacology, Toxicology and Pharmaceutics
Language:English
Date:2002
Deposited On:13 May 2014 12:12
Last Modified:11 Nov 2023 02:42
Publisher:Elsevier
ISSN:0024-3205
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/S0024-3205(02)01479-0