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Changes of cerebral tissue oxygen saturation at sleep transitions in adolescents


Metz, A J; Pugin, F; Huber, R; Achermann, P; Wolf, M (2014). Changes of cerebral tissue oxygen saturation at sleep transitions in adolescents. In: Swartz, Harold M; Harrison, David K; Bruley, Duane F. Oxygen Transport to Tissue XXXVI. New York: Springer, 279-285.

Abstract

In adults, cerebral oxy-([O2Hb]) and deoxyhemoglobin concentrations ([HHb]) change characteristically at transitions of sleep stages. The aims were to assess these changes in adolescents and additionally to measure tissue oxygen saturation (StO2) by near infrared spectroscopy (NIRS). Previously it was reported that in adults [O2Hb] increased and [HHb] decreased at the transition from non-rapid eye movement sleep (NREMS) to REMS and wakefulness. Transitions to NREMS from REMS/wakefulness led to a decrease in [O2Hb] and an increase in [HHb]. We measured [O2Hb], [HHb] and tissue oxygenation (StO2) with NIRS approximately above the left prefrontal cortex in 12 healthy adolescent males (aged 10-16 years). We found comparable signs and magnitudes of changes in [O2Hb] and [HHb] as observed in adults. StO2 increased at the transitions from NREMS to REMS and decreased from REMS to NREMS and at sleep onset (all p < 0.01, linear mixed effects model). Changes in oxygen metabolism during sleep transitions are similar in adolescents and adults. In addition, we show for the first time temporal changes of StO2 at sleep transitions.

Abstract

In adults, cerebral oxy-([O2Hb]) and deoxyhemoglobin concentrations ([HHb]) change characteristically at transitions of sleep stages. The aims were to assess these changes in adolescents and additionally to measure tissue oxygen saturation (StO2) by near infrared spectroscopy (NIRS). Previously it was reported that in adults [O2Hb] increased and [HHb] decreased at the transition from non-rapid eye movement sleep (NREMS) to REMS and wakefulness. Transitions to NREMS from REMS/wakefulness led to a decrease in [O2Hb] and an increase in [HHb]. We measured [O2Hb], [HHb] and tissue oxygenation (StO2) with NIRS approximately above the left prefrontal cortex in 12 healthy adolescent males (aged 10-16 years). We found comparable signs and magnitudes of changes in [O2Hb] and [HHb] as observed in adults. StO2 increased at the transitions from NREMS to REMS and decreased from REMS to NREMS and at sleep onset (all p < 0.01, linear mixed effects model). Changes in oxygen metabolism during sleep transitions are similar in adolescents and adults. In addition, we show for the first time temporal changes of StO2 at sleep transitions.

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Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology

04 Faculty of Medicine > Center for Integrative Human Physiology
06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:2014
Deposited On:20 May 2014 15:02
Last Modified:14 Feb 2018 21:15
Publisher:Springer
Series Name:Advances in Experimental Medicine and Biology
Number:812
ISSN:0065-2598
ISBN:978-1-4939-0583-6
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/978-1-4939-0620-8_37
PubMed ID:24729244

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