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Polyomavirus BK and prostate cancer: an unworthy scientific effort?


Delbue, Serena; Ferrante, Pasquale; Provenzano, Maurizio (2014). Polyomavirus BK and prostate cancer: an unworthy scientific effort? Oncoscience, 1(4):296-303.

Abstract

The Polyomavirus BK (BKV) has been proposed to be one of the possible co-factors in the genesis of prostate cancer (PCa) but, so far, the only convincing suggestion is the hypothesis of a “hit and run” carcinogenic mechanism induced by the virus at early stages of this disease. To support this hypothesis we conducted an updated systematic review on previous studies regarding the association between BKV and PCa, in order to interpret the contrasting results and to explore whether there might be a significant virus-disease link. This updated analysis provides evidence for a significant link between BKV expression and PCa development, particularly between the BKV infection and the cancer risk. Forthcoming scientific efforts that take cue from this study might overcome the atavistic and fruitless debate regarding the BKV-PCa association.

Abstract

The Polyomavirus BK (BKV) has been proposed to be one of the possible co-factors in the genesis of prostate cancer (PCa) but, so far, the only convincing suggestion is the hypothesis of a “hit and run” carcinogenic mechanism induced by the virus at early stages of this disease. To support this hypothesis we conducted an updated systematic review on previous studies regarding the association between BKV and PCa, in order to interpret the contrasting results and to explore whether there might be a significant virus-disease link. This updated analysis provides evidence for a significant link between BKV expression and PCa development, particularly between the BKV infection and the cancer risk. Forthcoming scientific efforts that take cue from this study might overcome the atavistic and fruitless debate regarding the BKV-PCa association.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Life Sciences > Cancer Research
Language:English
Date:30 April 2014
Deposited On:03 Jun 2014 15:08
Last Modified:30 Jul 2020 13:43
Publisher:Impact Journals, LLC
ISSN:2331-4737
OA Status:Hybrid
Free access at:Official URL. An embargo period may apply.
Publisher DOI:https://doi.org/10.18632/oncoscience.35
Official URL:http://www.impactjournals.com/oncoscience/files/papers/1/32/32.pdf

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