Sivasankaran, R; Calleja, M; Morata, G; Basler, K (2000). The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family. Mechanisms of Development, 91(1-2):427-431.
Here we report the identification of Dfz3, a novel member of the Frizzled family of seven-pass transmembrane receptors. Like Dfz2, Dfz3 is a target gene of Wingless (Wg) signalling, but in contrast to Dfz2, it is activated rather than repressed by Wg signalling in imaginal discs. We show that Dfz3 is not required for viability but is necessary for optimal Wg signalling at the wing margin.
Here we report the identification of Dfz3, a novel member of the Frizzled family of seven-pass transmembrane receptors. Like Dfz2, Dfz3 is a target gene of Wingless (Wg) signalling, but in contrast to Dfz2, it is activated rather than repressed by Wg signalling in imaginal discs. We show that Dfz3 is not required for viability but is necessary for optimal Wg signalling at the wing margin.
| Item Type: | Journal Article, refereed |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Institute of Molecular Life Sciences |
| Dewey Decimal Classification: | 570 Life sciences; biology |
| Scopus Subject Areas: | Health Sciences > Embryology
Life Sciences > Developmental Biology |
| Language: | English |
| Date: | 1 March 2000 |
| Deposited On: | 11 Feb 2008 12:19 |
| Last Modified: | 23 Jan 2022 08:42 |
| Publisher: | Elsevier |
| ISSN: | 0925-4773 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1016/S0925-4773(99)00313-5 |
| PubMed ID: | 10704878 |
Sivasankaran, R