Integrated CT-perfusion shows no meaningful correlation with PSA and pre-surgical Gleason score in patients with early prostate cancer

Abstract

OBJECTIVES To analyze the correlation of computed tomography (CT) perfusion parameters blood flow (BF), blood volume (BV), and mean transit time (MTT) with presurgical prostate cancer data. METHODS Ninety-eight patients with biopsy-proven prostate cancer underwent a CT-perfusion scan of the prostate. MTT, BF, and BV were determined and correlated with prostate-specific antigen (PSA) level, tumor load and Gleason score of transrectal ultrasonography-guided biopsy specimens. RESULTS Mean BF was 41.3 ml/100 ml*min(-1), BV 5.2 ml/100 ml, MTT 8.7 s. Moderate correlations were observed between Gleason score and BF (0.35) and between PSA and BF (0.33) and BV (0.30). CONCLUSIONS CT-perfusion shows no valuable correlation with presurgical prostate cancer data.