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Is auditory evoked potential aufmenting/reducing affected by acute tryptophan depletion?

Debener, S; Strobel, A; Maercker, Andreas; Beauducel, A; Brocke, B (2002). Is auditory evoked potential aufmenting/reducing affected by acute tryptophan depletion? Biological Psychology, 59:121-133.

Abstract

Several lines of evidence suggest that the auditory evoked potential (AEP) augmenting/reducing slope may serve as a biological marker of central serotonergic activity. According to Hegerl and Juckel (Biol. Psychiatry, 33, 1993, 173), reduced serotonergic activity is hypothesized to increase the slope of the AEP amplitude stimulus intensity function (ASF-slope). Hints for this hypothesis were investigated by employing the acute tryptophan depletion paradigm in 18 healthy females. A within-subject, placebo controlled double-blind cross over design was used for that purpose. Subjects ingested both a 50 g amino-acid drink with (placebo condition) and without tryptophan (depletion condition). With respect to the N1/P2-slope, test–retest reliability of a 1 week interval ranged between r=0.56 and 0.58 for the pre-ingestion baseline recording sessions. Affect was not altered by tryptophan depletion and not related to the ASF-slope. The comparison between placebo and depletion conditions did not reveal significant alterations of the ASF-slope, neither after 5 nor 6 h post-ingestion. Thus, the results do not support the assumption of the ASF-slope reflecting central serotonergic function.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
Scopus Subject Areas:Life Sciences > General Neuroscience
Social Sciences & Humanities > Neuropsychology and Physiological Psychology
Language:English
Date:2002
Deposited On:22 Oct 2014 08:35
Last Modified:11 Jul 2025 01:39
Publisher:Elsevier
ISSN:0301-0511
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/S0301-0511(01)00132-6
PubMed ID:11911935
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