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Asquith, Christopher R M; Meli, Marina L; Konstantinova, Lidia S; Laitinen, Tuomo; Peräkylä, Mikael; Poso, Antti; Rakitin, Oleg A; Allenspach, Karin; Hofmann-Lehmann, Regina; Hilton, Stephen T (2014). Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection. Bioorganic & Medicinal Chemistry Letters, 24(12):2640-2644.
A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 05 Vetsuisse Faculty > Veterinary Clinic > Department of Clinical Diagnostics and Services
05 Vetsuisse Faculty > Center for Clinical Studies |
| Dewey Decimal Classification: | 570 Life sciences; biology
630 Agriculture |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Medicine Life Sciences > Molecular Biology Life Sciences > Pharmaceutical Science Life Sciences > Drug Discovery Life Sciences > Clinical Biochemistry Physical Sciences > Organic Chemistry |
| Language: | English |
| Date: | 15 June 2014 |
| Deposited On: | 30 Oct 2014 09:52 |
| Last Modified: | 03 Nov 2024 04:40 |
| Publisher: | Elsevier |
| ISSN: | 0960-894X |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1016/j.bmcl.2014.04.073 |
| PubMed ID: | 24813732 |
Asquith, Christopher R M