Deuel, J W; Schaer, C A; Boretti, F S; Opitz, L; Garcia-Rubio, I; Baek, J H; Spahn, D R; Buehler, P W; Schaer, D J (2016). Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response. Cell Death and Disease, 7:e2064.
Deuel, J W; Puglia, M; Buehler, P W; Schaer, C A; Vallelian, Florence; Schaer, D (2015). Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity. Free Radical Biology & Medicine, 89:931-943.
Vallelian, F; Deuel, J W; Opitz, L; Schaer, C A; Puglia, M; Lönn, M; Engelsberger, W; Schauer, S; Karnaukhova, E; Spahn, D R; Stocker, R; Buehler, P W; Schaer, D J (2015). Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress. Cell Death and Differentiation, 22(4):597-611.
Boretti, F S; Baek, J H; Palmer, A F; Schaer, D J; Buehler, P W (2014). Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications. Frontiers in Physiology:5:385.
Schaer, D J; Buehler, P W; Alayash, A I; Belcher, J D; Vercellotti, G M (2013). Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood, 121(8):1276-1284.
Baek, J H; Zhou, Y; Harris, D R; Schaer, D J; Palmer, A F; Buehler, P W (2012). Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model. Toxicological Sciences, 127(2):567-581.
Widmer, C C; Pereira, C P; Gehrig, P; Vallelian, F; Schoedon, G; Buehler, P W; Schaer, D J (2010). Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase. Antioxidants and Redox Signaling, 12(2):185-198.
Buehler, P W; D'Agnillo, F; Schaer, D J (2010). Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design. Trends in Molecular Medicine, 16(10):447-457.
Pimenova, T; Pereira, C P; Gehrig, P; Buehler, P W; Schaer, D J; Zenobi, R (2010). Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin. Journal of Proteome Research, 9(8):4061-4070.
Buehler, P W; Abraham, B; Vallelian, F; Linnemayr, C; Pereira, C P; Cipollo, J F; Jia, Y; Mikolajczyk, M; Boretti, F S; Schoedon, G; Alayash, A I; Schaer, D J (2009). Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood, 113(11):2578-2586.
Boretti, F S; Buehler, P W; D'Agnillo, F; Kluge, K; Glaus, T M; Butt, O I; Jia, Y; Goede, J; Pereira, C P; Maggiorini, M; Schoedon, G; Alayash, A I; Schaer, D J (2009). Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. Journal of Clinical Investigation, 119(8):2271-2280.
Buehler, P W; Vallelian, F; Mikolajczyk, M G; Schoedon, G; Schweizer, T; Alayash, A I; Schaer, D J (2008). Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways. Antioxidants and Redox Signaling, 10(8):1449-1462.