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07 Faculty of Science > Institute of Molecular Cancer Research"

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Dibitetto, Diego; Liptay, Martin; Vivalda, Francesca; Dogan, Hülya; Gogola, Ewa; González Fernández, Martín; Duarte, Alexandra; Schmid, Jonas A; Decollogny, Morgane; Francica, Paola; Przetocka, Sara; Durant, Stephen T; Forment, Josep V; Klebic, Ismar; Siffert, Myriam; de Bruijn, Roebi; Kousholt, Arne N; Marti, Nicole A; Dettwiler, Martina; Sørensen, Claus S; Tille, Jean-Christophe; Undurraga, Manuela; Labidi-Galy, Intidhar; Lopes, Massimo; Sartori, Alessandro A; Jonkers, Jos; Rottenberg, Sven (2024). H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours. Nature Communications, 15(1):4430.

Saguner-Bonetti, Nicole Regula. Inflammaging as a Mediator of Age-Dependent Cardiovascular Disease – an Investigation of Underlying Mechanisms and Potential Therapeutic and Preventive Targets. 2024, University of Zurich, Faculty of Science.

Lynch, Jennifer; Troadec, Estelle; Fung, Tsz Kan; Gladysz, Kornelia; Virely, Clemence; Lau, Priscilla Nga Ieng; Cheung, Ngai; Zeisig, Bernd; Wong, Jason Wing Hon; Lopes, Massimo; Huang, Suming; So, Chi Wai Eric (2024). Hematopoietic stem cell quiescence and DNA replication dynamics maintained by the resilient β-catenin/Hoxa9/Prmt1 axis. Blood, 143(16):1586-1598.

Ulferts, Svenja; Lopes, Massimo; Miyamoto, Kei; Grosse, Robert (2024). Nuclear actin dynamics and functions at a glance. Journal of Cell Science, 137(6):jcs261630.

Andronic, Octavian; Chaharbakhshi, Edwin O; Zingg, Patrick O; Germann, Christoph; Rahm, Stefan; Lall, Ajay C; Domb, Benjamin G (2024). No Difference in Patient-Reported Outcomes for Periacetabular Osteotomy and Hip Arthroscopy With Capsular Plication in the Setting of Borderline Hip Dysplasia: A Propensity-Matched Multicenter Study With Minimum 5-Year Follow-up. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 40(3):754-762.

Muñoz, Sergio; Blanco-Romero, Elena; González-Acosta, Daniel; Rodriguez-Acebes, Sara; Megías, Diego; Lopes, Massimo; Méndez, Juan (2024). RAD51 restricts DNA over-replication from re-activated origins. The EMBO Journal, 43(6):1043-1064.

González-Acosta, Daniel; Lopes, Massimo (2024). DNA replication and replication stress response in the context of nuclear architecture. Chromosoma, 133(1):57-75.

Martinikova, Andra S; Stoyanov, Miroslav; Oravetzova, Anna; Kok, Yannick P; Yu, Shibo; Dobrovolna, Jana; Janscak, Pavel; van Vugt, Marcel; Macurek, Libor (2024). PPM1D activity promotes the replication stress caused by cyclin E1 overexpression. Molecular Oncology, 18(1):6-20.

Chanou, Anna; Weiβ, Matthias; Holler, Karoline; Sajid, Atiqa; Straub, Tobias; Krietsch, Jana; Sanchi, Andrea; Ummethum, Henning; Lee, Clare S K; Kruse, Elisabeth; Trauner, Manuel; Werner, Marcel; Lalonde, Maxime; Lopes, Massimo; Scialdone, Antonio; Hamperl, Stephan (2023). Single molecule MATAC-seq reveals key determinants of DNA replication origin efficiency. Nucleic Acids Research, 51(22):12303-12324.

Palumbieri, Maria Dilia; Merigliano, Chiara; González-Acosta, Daniel; Kuster, Danina; Krietsch, Jana; Stoy, Henriette; von Känel, Thomas; Ulferts, Svenja; Welter, Bettina; Frey, Joël; Doerdelmann, Cyril; Sanchi, Andrea; Grosse, Robert; Chiolo, Irene; Lopes, Massimo (2023). Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity. Nature Communications, 14(1):7819.

He, Jiazhuo; Nascakova, Zuzana; Leary, Peter; Papa, Giovanni; Valenta, Tomas; Basler, Konrad; Müller, Anne (2023). Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells. Science Advances, 9(46):eadh0322.

Nieuwland, Arend J; Waibel, Felix W A; Flury, Andreas; Lisy, Marcus; Berli, Martin C; Lipsky, Benjamin A; Uçkay, İlker; Schöni, Madlaina (2023). Initial antibiotic therapy for postoperative moderate or severe diabetic foot infections: Broad versus narrow spectrum, empirical versus targeted. Diabetes, Obesity & Metabolism, 25(11):3290-3297.

Hochreiter, Bettina; Selman, Farah; Calek, Anna-Katharina; Kriechling, Philipp; Götschi, Tobias; Grubhofer, Florian; Wieser, Karl; Bouaicha, Samy (2023). Why is female gender associated with poorer clinical outcome after reverse total shoulder arthroplasty? Journal of Shoulder and Elbow Surgery, 32(11):2355-2365.

Wildschut, Mattheus H E; Mena, Julien; Dördelmann, Cyril; van Oostrum, Marc; Hale, Benjamin D; Settelmeier, Jens; Festl, Yasmin; Lysenko, Veronika; Schürch, Patrick M; Ring, Alexander; Severin, Yannik; Bader, Michael S; Pedrioli, Patrick G A; Goetze, Sandra; van Drogen, Audrey; Balabanov, Stefan; Skoda, Radek C; Lopes, Massimo; Wollscheid, Bernd; Theocharides, Alexandre P A; Snijder, Berend (2023). Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis. Nature Communications, 14(1):6414.

Moro, Ramona N; Biswas, Uddipta; Kharat, Suhas S; Duzanic, Filip D; Das, Prosun; Stavrou, Maria; Raso, Maria C; Freire, Raimundo; Chaudhuri, Arnab Ray; Sharan, Shyam K; Penengo, Lorenza (2023). Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15. Nature Communications, 14(1):6140.

Suter, Daniel; Hodel, Sandro; Liebmann, Florentin; Fürnstahl, Philipp; Farshad, Mazda (2023). Factors affecting augmented reality head-mounted device performance in real OR. European Spine Journal, 32(10):3425-3433.

Clerbaux, Laure-Alix; Cordier, Pierre; Desboeufs, Nina; Unger, Kristian; Leary, Peter; Semere, Gabriel; Boege, Yannick; Chan, Lap Kwan; Desdouets, Chantal; Lopes, Massimo; Weber, Achim (2023). Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma. JHEP Reports, 5(10):100838.

Imhoff, Florian B; Vlachopoulos, Lazaros (2023). Slope und frontale Achse: 3-dimensionale Analyse und Korrektur mit patientenspezifischen Schnittblöcken an der proximalen Tibia. Operative Orthopädie und Traumatologie, 35(5):248-257.

Rastokina, Anastasia; Cebrián, Jorge; Mozafari, Negin; Mandel, Nicholas H; Smith, C I Edvard; Lopes, Massimo; Zain, Rula; Mirkin, Sergei M (2023). Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers. Nucleic Acids Research, 51(16):8532-8549.

Lalji, Rahim; Hincapié, Cesar A; Macpherson, Alison; Howitt, Scott; Marshall, Cameron; Tamim, Hala (2023). Association Between First Attempt Buffalo Concussion Treadmill Test and Days to Recovery in 855 Children With Sport-Related Concussion: A Historical Cohort Study and Prognostic Factors Analysis. Clinical Journal of Sport Medicine, 33(5):505-511.

Calek, Anna-Katharina; Altorfer, Franziska; Fasser, Marie-Rosa; Widmer, Jonas; Farshad, Mazda (2023). Interspinous and spinolaminar synthetic vertebropexy of the lumbar spine. European Spine Journal, 32(9):3183-3191.

Fritz, Benjamin; de Cesar Netto, Cesar; Fritz, Jan (2023). Multiaxial 3D MRI of the Ankle: Advanced High-Resolution Visualization of Ligaments, Tendons, and Articular Cartilage. Foot and Ankle Clinics, 28(3):529-550.

Bahl, Anisha; Horgan, Conor C; Janatka, Mirek; MacCormac, Oscar J; Noonan, Philip; Xie, Yijing; Qiu, Jianrong; Cavalcanti, Nicola; Fürnstahl, Philipp; Ebner, Michael; Bergholt, Mads S; Shapey, Jonathan; Vercauteren, Tom (2023). Synthetic white balancing for intra-operative hyperspectral imaging. Journal of Medical Imaging, 10(4):046001.

Hincapié, Cesar A; Hofstetter, Léonie; Lalji, Rahim; Korner, Longin; Schläppi, Mireille C; Leemann, Serafin (2023). Use of electronic patient records and encrypted email patient communication among Swiss chiropractors: a population-based cross-sectional study. Chiropractic and Manual Therapies, 31(1):21.

Andronic, Octavian; Germann, Christoph; Jud, Lukas; Zingg, Patrick O (2023). Factors influencing patient-reported outcomes following periacetabular osteotomy and open osteochondroplasty in the setting of borderline hip dysplasia. The Bone & Joint Journal, 105-B(7):735-742.

Calek, Anna-Katharina; Tsagkaris, Christos; Fasser, Marie-Rosa; Widmer, Jonas; Hagel, Vincent; Farshad, Mazda (2023). Biomechanical limitations of partial pediculectomy in endoscopic spine surgery. The Spine Journal, 23(7):1088-1095.

Karczewski, Daniel; Bäcker, Henrik; Andronic, Octavian; Bedi, Angad; Adelhoefer, Siegfried; Müllner, Maximilian; Gonzalez, Marcos R (2023). Serratia marcescens prosthetic joint infection: two case reports and a review of the literature. Journal of Medical Case Reports, 17(1):294.

Zhang, Lihang; Li, Changzhao; Zhang, Jiaying; Zou, Diyang; Dimitriou, Dimitris; Xing, Xing; Tsai, Tsung-Yuan; Li, Pingyue (2023). Significant race and gender differences in anterior cruciate ligament tibial footprint location: a 3D-based analysis. Journal of Orthopaedics and Traumatology, 24(1):33.

Marhofer, Peter; Eichenberger, Urs (2023). Augmented reality in ultrasound-guided regional anaesthesia: useful tool or expensive toy? British Journal of Anaesthesia, 131(3):442-445.

Götschi, Tobias; Hodel, Sandro; Kühne, Nathalie; Bachmann, Elias; Li, Xiang; Zimmermann, Stefan M; Snedeker, Jess G; Fucentese, Sandro F (2023). Osteoconductive Scaffold Placed at the Femoral Tunnel Aperture in Hamstring Tendon ACL Reconstruction: A Randomized Controlled Trial. Orthopaedic Journal of Sports Medicine, 11(6):23259671231174478.

Burkhard, Marco D; Calek, Anna-Katharina; Fasser, Marie-Rosa; Cornaz, Frédéric; Widmer, Jonas; Spirig, José Miguel; Wanivenhaus, Florian; Farshad, Mazda (2023). Biomechanics after spinal decompression and posterior instrumentation. European Spine Journal, 32(6):1876-1886.

Gasser, Benedikt; Frey, Walter O; Valdivieso, Paola; Scherr, Johannes; Spörri, Jörg; Flück, Martin (2023). Association of Gene Variants with Seasonal Variation in Muscle Strength and Aerobic Capacity in Elite Skiers. Genes, 14(6):1165.

Pomella, Silvia; Danielli, Sara G; Alaggio, Rita; Breunis, Willemijn B; Hamed, Ebrahem; Selfe, Joanna; Wachtel, Marco; Walters, Zoe S; Schäfer, Beat W; Rota, Rossella; Shipley, Janet M; Hettmer, Simone (2023). Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma. Cancers, 15(10):2823.

Olearo, Flaminia; Zanichelli, Veronica; Exarchakou, Aimilia; Both, Anna; Uςkay, Ilker; Aepfelbacher, Martin; Rohde, Holger (2023). The Impact of Antimicrobial Therapy Duration in the Treatment of Prosthetic Joint Infections Depending on Surgical Strategies: A Systematic Review and Meta-analysis. Open Forum Infectious Diseases, 10(5):ofad246.

Hinse, Stephanie; Pastor, Torsten; Hasler, Anita; Ernstbrunner, Lukas; Wieser, Karl; Gerber, Christian (2023). Mid- to long-term clinical and radiological results of anatomic total shoulder arthroplasty in patients with B2 glenoids. JSES International, 7(3):464-471.

Farshad, Mazda; Tsagkaris, Christos; Widmer, Jonas; Fasser, Marie-Rosa; Cornaz, Frédéric; Calek, Anna-Katharina (2023). Vertebropexy as a semi-rigid ligamentous alternative to lumbar spinal fusion. European Spine Journal, 32(5):1695-1703.

Karczewski, Daniel; Andronic, Octavian; Akgün, Doruk; Adelhoefer, Siegfried; Kriechling, Philipp; Bäcker, Henrik (2023). No clinical consequence of liner malseating in dual-mobility THAs at short term: a systematic review. Archives of Orthopaedic and Trauma Surgery, 143(10):6453-6459.

Lalji, Rahim; Hofstetter, Léonie; Kongsted, Alice; von Wyl, Viktor; Puhan, Milo A; Hincapié, Cesar A (2023). The Swiss chiropractic practice-based research network: a population-based cross-sectional study to inform future musculoskeletal research. Scientific Reports, 13(1):5655.

Furrer, Pascal Raffael; Kabelitz, Method; Schweizer, Andreas (2023). Quantification of Malalignment and Corrective Osteotomies in Patients With Malunion After Elastic Stable Intramedullary Nailing of Pediatric Forearm Fractures. Journal of hand surgery global online, 5(3):332-337.

Chianca, Vito; Sutter, Reto; Del Grande, Filippo (2023). Erratum: Imaging of Anatomical Variants Around the Elbow. Seminars in Musculoskeletal Radiology, 27(2):e1.

Chianca, Vito; Sutter, Reto; Del Grande, Filippo (2023). Imaging of Anatomical Variants Around the Elbow. Seminars in Musculoskeletal Radiology, 27(2):163-168.

Schöni, Madlaina; Waibel, Felix (2023). Technische Orthopädie – Chronische Wunden im Bereich der diabetischen Füsse. Praxis, 112(5-6):317-323.

Altmann, Dominique; Waibel, Felix W A; Forgo, Gabor; Grigorean, Alexandru; Lipsky, Benjamin A; Uçkay, Ilker; Schöni, Madlaina (2023). Timing of Revascularization and Parenteral Antibiotic Treatment Associated with Therapeutic Failures in Ischemic Diabetic Foot Infections. Antibiotics, 12(4):685.

Müller, Anne; He, Jiazhuo (2023). A Double Whammy on Gastric Cancer Risk. New England Journal of Medicine, 388(13):1225-1229.

Andrs, Martin; Stoy, Henriette; Boleslavska, Barbora; Chappidi, Nagaraja; Kanagaraj, Radhakrishnan; Nascakova, Zuzana; Menon, Shruti; Rao, Satyajeet; Oravetzova, Anna; Dobrovolna, Jana; Surendranath, Kalpana; Lopes, Massimo; Janscak, Pavel (2023). Excessive reactive oxygen species induce transcription-dependent replication stress. Nature Communications, 14(1):1791.

Han, Zhe; Andrs, Martin; Madhavan, Bindhu K; Kaymak, Serap; Sulaj, Alba; Kender, Zoltan; Kopf, Stefan; Kihm, Lars; Pepperkok, Rainer; Janscak, Pavel; Nawroth, Peter; Kumar, Varun (2023). The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress. Nucleic Acids Research, 51(5):2298-2318.

Fernández, Maria T; Aguirre, José A; López, Servando (2023). Posterior Quadratus Lumborum Block, A Novel Approach to Treat Chronic Hip Pain: A Case Series. A & A Practice, 17(3):e01671.

Hanimann, Jonas; Ellenberger, Lynn; Bernhard, Thomas; Franchi, Martino V; Roth, Ralf; Faude, Oliver; Spörri, Jörg (2023). More than just a side effect: Dynamic knee valgus and deadbug bridging performance in youth soccer players and alpine skiers have similar absolute values and asymmetry magnitudes but differ in terms of the direction of laterality. Frontiers in Physiology, 14:1129351.

Paszicsnyek, Alexander; Kriechling, Philipp; Razaeian, Sam; Ernstbrunner, Lukas; Wieser, Karl; Borbas, Paul (2023). Reverse Total Shoulder Arthroplasty for Proximal Humeral Fractures and Sequalae Compared to Non-Fracture Indications: A Matched Cohort Analysis of Outcome and Complications. Journal of Clinical Medicine, 12(6):2097.

Burkhard, Marco D; Cornaz, Frédéric; Spirig, José Miguel; Wanivenhaus, Florian; Fasser, Marie-Rosa; Widmer, Jonas; Farshad, Mazda (2023). Residual motion of cortical versus pedicle screw constructs after decompression, interbody fusion and cross-link augmentation. European Spine Journal, 32(4):1401-1410.

Stoy, Henriette; Zwicky, Katharina; Kuster, Danina; Lang, Kevin S; Krietsch, Jana; Crossley, Magdalena P; Schmid, Jonas A; Cimprich, Karlene A; Merrikh, Houra; Lopes, Massimo (2023). Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids. Nature Structural & Molecular Biology, 30(3):348-359.

Hasler, Julian; Flury, Andreas; Hoch, Armando; Cornaz, Frédéric; Zingg, Patrick O; Rahm, Stefan (2023). Total hip arthroplasty through the direct anterior approach for sequelae of Legg-Calvé-Perthes disease. Archives of Orthopaedic and Trauma Surgery, 143(9):5935-5944.

Unterfrauner, Ines; Andronic, Octavian; Viehöfer, Arnd F; Wirth, Stephan H; Berli, Martin C; Waibel, Felix W A (2023). Ulcer occurrence on adjacent toes and hallux valgus deformity after amputation of the second toe in diabetic patients. Journal of Orthopaedic Surgery and Research, 18(1):99.

Kutafina, Ekaterina; Becker, Susanne; Namer, Barbara (2023). Measuring pain and nociception: Through the glasses of a computational scientist. Transdisciplinary overview of methods. Frontiers in Network Physiology, 3:1099282.

Danielli, Sara G; Porpiglia, Ermelinda; De Micheli, Andrea J; Navarro, Natalia; Zellinger, Michael J; Bechtold, Ingrid; Kisele, Samanta; Volken, Larissa; Marques, Joana G; Kasper, Stephanie; Bode, Peter K; Henssen, Anton G; Gürgen, Dennis; Delattre, Olivier; Surdez, Didier; Roma, Josep; Bühlmann, Peter; Blau, Helen M; Wachtel, Marco; Schäfer, Beat W (2023). Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance. Science Advances, 9(6):eade9238.

Grisch, Domenic; Stäuble, Manuela; Baumgartner, Sandra; van Hedel, Hubertus J A; Meyer-Heim, Andreas; Dreher, Thomas; Krautwurst, Britta (2023). The Variable Influence of Orthotic Management on Hip and Pelvic Rotation in Children with Unilateral Neurogenic Equinus Deformity. Children, 10(2):307.

Uçkay, Ilker; Lebowitz, Dan; Kressmann, Benjamin; Lipsky, Benjamin A; Gariani, Karim (2023). Influence of Skin Commensals on Therapeutic Outcomes of Surgically Debrided Diabetic Foot Infections-A Large Retrospective Comparative Study. Antibiotics, 12(2):316.

Selman, Farah; Kriechling, Philipp; Ernstbrunner, Lukas; Wieser, Karl; Borbas, Paul (2023). Greater Tuberosity Fractures after RTSA: A Matched Group Analysis. Journal of Clinical Medicine, 12(3):1153.

Stirm, Kristin; Leary, Peter; Wüst, Daria; Stark, Dominique; Joller, Nicole; Karakus, Ufuk; Boyman, Onur; Tzankov, Alexandar; Müller, Anne (2023). Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models. Journal for ImmunoTherapy of Cancer, 11(2):e006263.

Reuter, Sebastian; Raspe, Jonas; Uebner, Hendrik; Contoyannis, Alexandros; Pastille, Eva; Westendorf, Astrid M; Caso, Georgia C; Cover, Timothy L; Müller, Anne; Taube, Christian (2023). Treatment with Helicobacter pylori-derived VacA attenuates allergic airway disease. Frontiers in Immunology, 14:1092801.

Boleslavska, Barbora; Oravetzova, Anna; Shukla, Kaustubh; Nascakova, Zuzana; Ibini, Oluwakemi Ngozi; Hasanova, Zdenka; Andrs, Martin; Kanagaraj, Radhakrishnan; Dobrovolna, Jana; Janscak, Pavel (2022). DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells. Nucleic Acids Research, 50(21):12274-12290.

Jacobs, Kurt; Doerdelmann, Cyril; Krietsch, Jana; González-Acosta, Daniel; Mathis, Nicolas; Kushinsky, Saul; Guarino, Estrella; Gómez-Escolar, Carmen; Martinez, Dolores; Schmid, Jonas A; Leary, Peter J; Freire, Raimundo; Ramiro, Almudena R; Eischen, Christine M; Mendez, Juan; Lopes, Massimo (2022). Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming. Molecular Cell, 82(21):4176-4188.e8.

Dibitetto, Diego; Marshall, Shannon; Sanchi, Andrea; Liptay, Martin; Badar, Jumana; Lopes, Massimo; Rottenberg, Sven; Smolka, Marcus B (2022). DNA-PKcs promotes fork reversal and chemoresistance. Molecular Cell, 82(20):3932-3942.e6.

Ruhen, Olivia; Lak, Nathalie S M; Stutterheim, Janine; Danielli, Sara G; et al; Surdez, Didier; Schäfer, Beat W (2022). Molecular Characterization of Circulating Tumor DNA in Pediatric Rhabdomyosarcoma: A Feasibility Study. JCO precision oncology, 6:e2100534.

Borbet, Timothy C; Pawline, Miranda B; Zhang, Xiaozhou; Wipperman, Matthew F; Reuter, Sebastian; Maher, Timothy; Li, Jackie; Iizumi, Tadasu; Gao, Zhan; Daniele, Megan; Taube, Christian; Koralov, Sergei B; Müller, Anne; Blaser, Martin J (2022). Influence of the early-life gut microbiota on the immune responses to an inhaled allergen. Mucosal Immunology, 15(5):1000-1011.

Orjuela, Stephany; Parker, Hannah R; Sajibu, Sija; Cereatti, Fabrizio; Sauter, Matthias; Buffoli, Federico; Robinson, Mark D; Marra, Giancarlo (2022). Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing. Epigenetics, 17(6):677-694.

Giansanti, Celeste; Manzini, Valentina; Dickmanns, Antje; Dickmanns, Achim; Palumbieri, Maria Dilia; Sanchi, Andrea; Kienle, Simon Maria; Rieth, Sonja; Scheffner, Martin; Lopes, Massimo; Dobbelstein, Matthias (2022). MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression. Cell Reports, 39(9):110879.

Larsen, Brian D; Benada, Jan; Yung, Philip Yuk Kwong; Bell, Ryan A V; Pappas, George; Urban, Vaclav; Ahlskog, Johanna K; Kuo, Tia T; Janscak, Pavel; Megeney, Lynn A; Elsässer, Simon J; Bartek, Jiri; Sørensen, Claus S (2022). Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress. Science, 376(6592):476-483.

Sakellariou, Despoina; Bak, Sara Thornby; Isik, Esin; Barroso, Sonia I; Porro, Antonio; Aguilera, Andrés; Bartek, Jiri; Janscak, Pavel; Peña-Diaz, Javier (2022). MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells. Cell Reports, 39(1):110602.

Fallegger, Angela; Priola, Martina; Artola-Borán, Mariela; Núñez, Nicolás Gonzalo; Wild, Sebastian; Gurtner, Alessandra; Becher, Burkhard; Yousefi, Shida; Simon, Hans-Uwe; Arnold, Isabelle C; Müller, Anne (2022). TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin - RORγt + regulatory T-cells during bacterial and allergen challenge. Mucosal Immunology, 15(3):504-514.

Boonen, Rick A C M; Wiegant, Wouter W; Celosse, Nandi; Vroling, Bas; Heijl, Stephan; Kote-Jarai, Zsofia; Mijuskovic, Martina; Cristea, Simona; Solleveld-Westerink, Nienke; van Wezel, Tom; Beerenwinkel, Niko; Eeles, Rosalind; Devilee, Peter; Vreeswijk, Maaike P G; Marra, Giancarlo; van Attikum, Haico (2022). Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk. Cancer Research, 82(4):615-631.

Bolck, Hella A; Przetocka, Sara; Meier, Roger; von Aesch, Christine; Zurfluh, Christina; Hänggi, Kay; Spegg, Vincent; Altmeyer, Matthias; Stebler, Michael; Nørrelykke, Simon F; Horvath, Peter; Sartori, Alessandro A; Porro, Antonio (2022). RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor. Cells, 11:643.

Artola-Borán, Mariela; Fallegger, Angela; Priola, Martina; Jeske, Rima; Waterboer, Tim; Dohlman, Anders B; Shen, Xiling; Wild, Sebastian; He, Jiazhuo; Levesque, Mitchell P; Yousefi, Shida; Simon, Hans-Uwe; Cheng, Phil F; Müller, Anne (2022). Mycobacterial infection aggravates Helicobacter pylori-induced gastric preneoplastic pathology by redirection of de novo induced Treg cells. Cell Reports, 38(6):110359.

Vokinger, Kerstin N; Kesselheim, Aaron S (2022). Value-based pricing of drugs with multiple indications or in combinations — lessons from Europe. Nature Reviews. Clinical Oncology, 19(1):1-2.

Stoy, Henriette; Luethi, Joel; Roessler, Fabienne K; Riemann, Johannes; Kaech, Andres; Lopes, Massimo (2022). Direct R-Loop Visualization on Genomic DNA by Native Automated Electron Microscopy. In: Aguilera, Andrés; Ruzov, Alexey. R-Loops: Methods and Protocols. New York: Springer, 1-20.

Stoy, Henriette; Lang, Kevin S; Merrikh, Houra; Lopes, Massimo (2022). Locus-Specific Analysis of Replication Dynamics and Detection of DNA-RNA Hybrids by Immuno Electron Microscopy. In: Aguilera, Andrés; Ruzov, Alexey. R-Loops: Methods and Protocols. New York: Springer, 67-89.

Tromans-Coia, Callum; Sanchi, Andrea; Moeller, Giuliana K; Timinszky, Gyula; Lopes, Massimo; Ahel, Ivan (2021). TARG1 protects against toxic DNA ADP-ribosylation. Nucleic Acids Research, 49(18):10477-10492.

Montalban-Arques, Ana; Katkeviciute, Egle; Busenhart, Philipp; Bircher, Anna; Wirbel, Jakob; Zeller, Georg; Morsy, Yasser; Borsig, Lubor; Glaus Garzon, Jesus Francisco; Müller, Anne; Arnold, Isabelle C; Artola-Borán, Mariela; Krauthammer, Michael; Sintsova, Anna; Zamboni, Nicola; Leventhal, Gabriel E; Berchtold, Laura; de Wouters, Tomas; Rogler, Gerhard; Baebler, Katharina; Schwarzfischer, Marlene; Hering, Larissa; Olivares-Rivas, Ivan; Atrott, Kirstin; Gottier, Claudia; Lang, Silvia; Boyman, Onur; Fritsch, Ralph M; Manz, Markus G; Spalinger, Marianne R; Scharl, Michael (2021). Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors. Cell Host & Microbe, 29(10):1573-1588.e7.

Bujosa, Aida; Moltó, Consolación; Hwang, Thomas J; Tapia, José Carlos; Vokinger, Kerstin N; Templeton, Arnoud J; Gich, Ignasi; Barnadas, Agustí; Amir, Eitan; Tibau, Ariadna (2021). Associations With Definitive Outcomes and Clinical Benefit of Cancer Drugs at the Time of Marketing Approval and in the Postmarketing Period. Journal of the National Comprehensive Cancer Network (JNCCN), 19(13):117-125.

Goold, Robert; Hamilton, Joseph; Menneteau, Thomas; Flower, Michael; Bunting, Emma L; Aldous, Sarah G; Porro, Antonio; Vicente, José R; Allen, Nicholas D; Wilkinson, Hilary; Bates, Gillian P; Sartori, Alessandro A; Thalassinos, Konstantinos; Balmus, Gabriel; Tabrizi, Sarah J (2021). FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease. Cell Reports, 36(9):109649.

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Mete, S. Targeting tumor microenvironment by zoledronate as a novel therapeutic approach in cancer. 2011, University of Zurich, Faculty of Science.

Arnold, I C; Hitzler, I; Engler, D; Oertli, M; Agger, E M; Müller, Anne (2011). The C-terminally encoded, MHC class II-restricted T cell antigenicity of the helicobacter pylori virulence factor CagA promotes gastric preneoplasia. Journal of Immunology, 186(11):6165-6172.

Eid, Wassim. The Role of Exonuclease-1 and its Interaction Partners in Genome Stability. 2011, University of Zurich, Faculty of Science.

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Schöpf, B. DNA mismatch repair and chromatin & functional characterisation of the zinc finger of KIAA1018. 2010, University of Zurich, Faculty of Science.

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Altmeyer, Matthias. Mechanism of poly(ADP-ribose) formation and the role of PARP1 in inflammation. 2010, University of Zurich, Faculty of Science.

Bhatia, Payal. Mechanism of regulation of protein kinase Aurora A in response to mitotic DNA damage. 2010, University of Zurich, Faculty of Science.

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Toller, Isabella Marietta. Molecular mechanisms of inflammation-induced cancer: T-cells as targets for prevention and cure of Heliobacter-related gastric preneoplasia. 2010, University of Zurich, Faculty of Science.

Craig, Vanessa Jane. Novel insights into the molecular pathogenesis of gastric MALT lymphoma. 2010, University of Zurich, Faculty of Science.

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Ferrari, S. Regulation of cell cycle transitions. 2010, University of Zurich, Faculty of Science.

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Arnold, I. The Balance Between Immunity nad Tolerance Determines the Outcome of H. pylori Infection. 2010, University of Zurich, Faculty of Science.

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Cattaneo, Elisa. The transcriptomic profiling of human colorectal precancerous lesions. 2010, University of Zurich, Faculty of Science.

Bonde, Anne-Katrine. Tumor associated macrophages regulate epithelial to mesenchymal transition in tumor cells in a TGF-β dependent manner. 2010, University of Zurich, Faculty of Science.

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Buob, Rebecca. DNA repair mechanism in the radioresistant bacterium Deinococcus radiodurans and in human. 2009, University of Zurich, Faculty of Science.

Lopes, Massimo (2009). Electron microscopy methods for studying in vivo DNA replication intermediates. Methods in Molecular Biology, 521:605-631.

Castor, D. Functional characterization of RuvB-like 1 during cell division. 2009, University of Zurich, Faculty of Science.

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Dorner, Marcus. Impact of innate and adaptive immunity on Epstein-Barr virus infection and persistence. 2009, University of Zurich, Faculty of Science.

Kehl, P. Inducible Gene Replacement of DNA Polymerase Delta. 2009, University of Zurich, Faculty of Science.

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Schott, H; Schott, S; Schwendener, R (2009). Synthesis and in vitro activities of new anticancer duplex drugs linking 2'-deoxy-5-fluorouridine (5-FdU) with 3'-C-ethynylcytidine (ECyd) via a phosphodiester bonding. Bioorganic & Medicinal Chemistry, 17(19):6824-6831.

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Marra, Giancarlo. Understanding tumorigenesis of the large intestine: The cornerstone of effective cancer prevention strategies. 2009, University of Zurich, Faculty of Science.

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Zheng, L. The role of human RECQ5 helicase in the maintenance of genomic stability revealed by protein-protein interaction study. 2008, University of Zurich, Faculty of Science.

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Schanz, S. Involvement of mismatch repair proteins in activation-induced deaminase-mediated antibody diversification. 2008, University of Zurich, Faculty of Science.

Neelsen, K J. A novel gene therapy approach for the treatment of tumours with microsatellite instability. 2008, University of Zurich, Faculty of Science.

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Radhakrishnan, Kanagaraj. Biochemistry of Human RecQ DNA Helicases and their Role in DNA Repair. 2008, University of Zurich, Faculty of Science.

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Rechsteiner, Markus. Function of latent membrane protein 2B in EBV-positive Burkitt's lymphoma. 2008, University of Zurich, Faculty of Science.

Hippert, C; Dubois, G; Morin, C; Disson, O; Ibanes, S; Jacquet, C; Schwendener, R; Antignac, C; Kremer, E J; Kalatzis, V (2008). Gene transfer may be preventive but not curative for a lysosomal transport disorder. Molecular Therapy, 16(8):1372-1381.

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Güthlein, Carolin. Investigation of DNA repair pathways and the impact of SMC protein on chromosome stability in mycobacteria. 2008, University of Zurich, Faculty of Science.

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Plaschke, J; Krüger, S; Jeske, B; Theissig, F; Kreuz, F R; Pistorius, S; Saeger, H D; Iaccarino, I; Marra, Giancarlo; Schackert, H K (2004). Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression. Cancer Research, 64(3):864-870.

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Stojic, L; Mojas, N; Cejka, P; Di Pietro, M; Ferrari, Stefano; Marra, Giancarlo; Jiricny, Josef (2004). Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes and Development, 18(11):1331-1344.

Grimm, J; Müller, Anne; Hefti, F; Rosenthal, A (2004). Molecular basis for catecholaminergic neuron diversity. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 101(38):13891-13896.

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Monack, D M; Müller, Anne; Falkow, S (2004). Persistent bacterial infections: the interface of the pathogen and the host immune system. Nature Reviews. Microbiology, 2(9):747-765.

El-Etr, A H; Müller, Anne; Tompkins, L S; Falkow, S; Merrell, D S (2004). Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers. Journal of Infectious Diseases, 190(8):1516-23.

Grossi, S; Puglisi, A; Dmitriev, P V; Lopes, Massimo; Shore, D (2004). Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes and Development, 18(9):992-1006.

Müller, Anne; Merrell, D S; Grimm, J; Falkow, S (2004). Profiling of microdissected gastric epithelial cells reveals a cell type-specific response to Helicobacter pylori infection. Gastroenterology, 127(5):1446-1462.

Garcia, P L; Bradley, G; Hayes, C H; Krintel, S J; Soultanas, P; Janscak, Pavel (2004). RPA alleviates the inhibitory effect of vinylphosphonate internucleotide linkages on DNA unwinding by BLM and WRN helicases. Nucleic Acids Research, 32(12):3771-3778.

Muheim-Lenz, R; Buterin, T; Marra, Giancarlo; Naegeli, H (2004). Short-patch correction of C/C mismatches in human cells. Nucleic Acids Research, 32(22):6696-6705.

Jiricny, J (2004). Unfaithful DNA polymerase caught in the act. Molecular Cell, 13(6):768-769.

Lopes, Massimo; Cotta-Ramusino, C; Liberi, G; Foiani, M (2003). Branch migrating sister chromatid junctions form at replication origins through Rad51/Rad52-independent mechanisms. Molecular Cell, 12(6):1499-1510.

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Sartori, Alessandro A. DNA Repair in the Hyperthermophilic Archaeon Pyrobaculum aerophilum. 2003, University of Zurich, Faculty of Science.

Jiricny, Josef; Marra, Giancarlo (2003). DNA repair defects in colon cancer. Current Opinion in Genetics & Development, 13(1):61-69.

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Cejka, P; Marra, Giancarlo; Hemmerle, C; Cannavó, E; Storchova, Z; Jiricny, J (2003). Differential killing of mismatch repair-deficient and -proficient cells: towards the therapy of tumors with microsatellite instability. Cancer Research, 63(23):8113-8117.

Müller, Anne; O'Rourke, J; Grimm, J; Guillemin, K; Dixon, M F; Lee, A; Falkow, S (2003). Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 100(3):1292-1297.

Sartori, Alessandro A; Jiricny, J (2003). Enzymology of base excision repair in the hyperthermophilic archaeon Pyrobaculum aerophilum. Journal of Biological Chemistry, 278(27):24563-24576.

Steinacher, R. Exploring regulatory mechanisms of DNA base excision mediated by human thymine-DNA glycosylase. 2003, University of Zurich, Faculty of Science.

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Jiricny, J (2002). DNA repair: bioinformatics helps reverse methylation damage. Current Biology, 12(24):R846-R848.

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Klingler, H; Hemmerle, C; Bannwart, F; Haider, R; Cattaruzza, M S; Marra, Giancarlo (2002). Expression of the hMSH6 mismatch-repair protein in colon cancer and HeLa cells. Swiss Medical Weekly, 132(5-6):57-63.

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Trojan, J; Zeuzem, S; Randolph, A; Hemmerle, C; Brieger, A; Raedle, J; Plotz, G; Jiricny, J; Marra, Giancarlo (2002). Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system. Gastroenterology, 122(1):211-219.

Alvino, E; Marra, Giancarlo; Pagani, E; Falcinelli, S; Pepponi, R; Perrera, C; Haider, R; Castiglia, D; Ferranti, G; Bonmassar, E; Jiricny, J; Zambruno, G; D'Atri, S (2002). High-frequency microsatellite instability is associated with defective DNA mismatch repair in human melanoma. Journal of Investigative Dermatology, 118(1):79-86.

Szadkowski, M; Jiricny, J (2002). Identification and functional characterization of the promoter region of the human MSH6 gene. Genes, Chromosomes & Cancer, 33(1):36-46.

Godthelp, B C; Wiegant, W W; van Duijn-Goedhart, A; Schärer, O D; van Buul, P P W; Kanaar, R; Zdzienicka, M Z (2002). Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Nucleic Acids Research, 30(10):2172-2182.

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Räschle, M; Dufner, P; Marra, Giancarlo; Jiricny, J (2002). Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha. Journal of Biological Chemistry, 277(24):21810-21820.

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Bentele, M. The role of uracil repair in the maintenance of genome stability in fission yeast. 2002, University of Zurich, Faculty of Science.

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Rajalingam, K; Al-Younes, H; Müller, Anne; Meyer, T F; Szczepek, A J; Rudel, T (2001). Epithelial cells infected with Chlamydophila pneumoniae (Chlamydia pneumoniae) are resistant to apoptosis. Infection and Immunity, 69(12):7880-7888.

Bentz, M; Barth, T F; Brüderlein, S; Bock, D; Schwerer, M J; Baudis, Michael; Joos, S; Viardot, A; Feller, A C; Müller-Hermelink, H K; Lichter, P; Döhner, H; Möller, P (2001). Gain of chromosome arm 9p is characteristic of primary mediastinal B-cell lymphoma (MBL): comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell line. Genes, Chromosomes & Cancer, 30(4):393-401.

Szadkowski, M. Genetic Analysis of the Human Mismatch Repair Gene MSH6 and Phenotypic Study of Cell Lines Mutated at this Locus. 2001, University of Zurich, Faculty of Science.

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Seiler, P; Schwendener, R; Bandermann, S; Brinkmann, V; Grode, L; Kaufmann, S H E; Aichele, P (2001). Limited mycobacterial infection of the liver as a consequence of its microanatomical structure causing restriction of mycobacterial growth to professional phagocytes. Infection and Immunity, 69(12):7922-7926.

Müller, Anne; Rudel, T (2001). Modification of host cell apoptosis by viral and bacterial pathogens. International Journal of Medical Microbiology, 291(3):197-207.

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Heinimann, K; Thompson, A; Locher, A; Furlanetto, T; Bader, E; Wolf, A; Meier, R; Walter, K; Bauerfeind, P; Marra, Giancarlo; Müller, H; Foernzler, D; Dobbie, Z (2001). Nontruncating APC germ-line mutations and mismatch repair deficiency play a minor role in APC mutation-negative polyposis. Cancer Research, 61(20):7616-7622.

Marra, Giancarlo; D'Atri, S; Yan, H; Perrera, C; Cannavo, Elda; Vogelstein, B; Jiricny, Josef (2001). Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes. Cancer Research, 61(21):7719-7721.

Marty, C; Scheidegger, P; Ballmer-Hofer, K; Klemenz, R; Schwendener, R (2001). Production of functionalized single-chain Fv antibody fragments binding to the ED-B domain of the B-isoform of fibronectin in Pichia pastoris. Protein Expression and Purification, 21(1):156-164.

Schärer, O D; Jiricny, J (2001). Recent progress in the biology, chemistry and structural biology of DNA glycosylases. BioEssays, 23(3):270-281.

Roscic-Mrkic, B; Schwendener, R; Odermatt, B; Zuniga, A; Pavlovic, J; Billeter, M A; Cattaneo, R (2001). Roles of macrophages in measles virus infection of genetically modified mice. Journal of Virology, 75(7):3343-3351.

Schär, P (2001). Spontaneous DNA damage, genome instability, and cancer--when DNA replication escapes control. Cell, 104(3):329-332.

Janscak, Pavel; Sandmeier, U; Szczelkun, M D; Bickle, T A (2001). Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I. Journal of Molecular Biology, 306(3):417-431.

Hardeland, U; Bentele, M; Lettieri, T; Steinacher, R; Jiricny, J; Schär, P (2001). Thymine DNA glycosylase. In: Moldave, K; Mitra, S; McCullough, A K; Lloyd, R S; Wilson, S H. Base Excision Repair. New York: Elsevier, 235-253.

Marra, Giancarlo; D'Atri, S; Corti, C; Bonmassar, L; Cattaruzza, M S; Schweizer, P; Heinimann, K; Bartosova, Z; Nyström-Lahti, M; Jiricny, J (2001). Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 98(13):7164-7169.

Kleczkowska, H E; Marra, Giancarlo; Lettieri, T; Jiricny, J (2001). hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. Genes and Development, 15(6):724-736.

Pepponi, R; Graziani, G; Falcinelli, S; Vernole, P; Levati, L; Lacal, P M; Pagani, E; Bonmassar, E; Jiricny, J; D'Atri, S (2001). hMSH3 overexpression and cellular response to cytotoxic anticancer agents. Carcinogenesis, 22(8):1131-1137.

Jiricny, J (2000). Mismatch repair: the praying hands of fidelity. Current Biology, 10(21):R788-R790.

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Hardeland, U. Biochemical Investigation into Structural and Functional Aspects of Thymine-DNA Glycosylases and the MBD4 Protein. 2000, University of Zurich, Faculty of Science.

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Räschle, M. Characterization of the human mismatch repair proteins hMLH1, hPMS1 nad hPMS2. 2000, University of Zurich, Faculty of Science.

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Janscak, Pavel; Bickle, T A (2000). DNA supercoiling during ATP-dependent DNA translocation by the type I restriction enzyme EcoAI. Journal of Molecular Biology, 295(4):1089-1099.

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Bearzatto, A; Szadkowski, M; Macpherson, P; Jiricny, J; Karran, P (2000). Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents. Cancer Research, 60(12):3262-3270.

Ludewig, B; Barchiesi, F; Pericin, M; Zinkernagel, R M; Hengartner, H; Schwendener, R (2000). In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity. Vaccine, 19(1):23-32.

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Dufner, P; Marra, Giancarlo; Räschle, M; Jiricny, Josef (2000). Mismatch recognition and DNA-dependent stimulation of the ATPase activity of hMutSalpha is abolished by a single mutation in the hMSH6 subunit. Journal of Biological Chemistry, 275(47):36550-36555.

Jiricny, J; Nyström-Lahti, M (2000). Mismatch repair defects in cancer. Current Opinion in Genetics & Development, 10(2):157-161.

Zhang, H; Marra, Giancarlo; Jiricny, J; Maher, V M; McCormick, J J (2000). Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts. Carcinogenesis, 21(9):1639-1646.

Iaccarino, I; Marra, Giancarlo; Dufner, P; Jiricny, J (2000). Mutation in the magnesium binding site of hMSH6 disables the hMutSalpha sliding clamp from translocating along DNA. Journal of Biological Chemistry, 275(3):2080-2086.

Hardeland, U; Bentele, M; Jiricny, J; Schär, P (2000). Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis. Journal of Biological Chemistry, 275(43):33449-33456.

Müller, Anne; Günther, D; Brinkmann, V; Hurwitz, R; Meyer, T F; Rudel, T (2000). Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells. The EMBO Journal, 19(20):5332-5543.

Lamers, M H; Perrakis, A; Enzlin, J H; Winterwerp, H H; de Wind, N; Sixma, T K (2000). The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature, 407(6805):711-717.

Cattaneo-Pangrazzi, R M; Schott, H; Schwendener, R (2000). The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145. Prostate, 45(1):8-18.

Barrett, T E; Schärer, O D; Savva, R; Brown, T; Jiricny, J; Verdine, G L; Pearl, L H (1999). Crystal structure of a thwarted mismatch glycosylase DNA repair complex. The EMBO Journal, 18(23):6599-6609.

Räschle, M; Marra, Giancarlo; Nyström-Lahti, M; Schär, P; Jiricny, J (1999). Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. Journal of Biological Chemistry, 274(45):32368-32375.

Koller-Lucae, S K; Schott, H; Schwendener, R (1999). Low density lipoprotein and liposome mediated uptake and cytotoxic effect of N4-octadecyl-1-beta-D-arabinofuranosylcytosine in Daudi lymphoma cells. British Journal of Cancer, 80(10):1542-9.

Koller-Lucae, S K; Suter, M J; Rentsch, K M; Schott, H; Schwendener, R (1999). Metabolism of the new liposomal anticancer drug N4-octadecyl-1-beta-D-arabinofuranosylcytosine in mice. Drug Metabolism and Disposition, 27(3):342-350.

Müller, Anne; Günther, D; Düx, F; Naumann, M; Meyer, T F; Rudel, T (1999). Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases. The EMBO Journal, 18(2):339-352.

Ludewig, B; Oehen, S; Barchiesi, F; Schwendener, R; Hengartner, H; Zinkernagel, R M (1999). Protective antiviral cytotoxic T cell memory is most efficiently maintained by restimulation via dendritic cells. Journal of Immunology, 163(4):1839-1844.

Schwendener, R; Peghini, P A; Ludwing, P S; Schott, H (1999). Synthesis, in vitro anti-HIV and anti-hepatitis B activities and pharmacokinetic properties of amphiphilic heterodinucleoside phosphates containing ddC and AZT. Nucleosides, Nucleotides & Nucleic Acids, 18(4-5):949-950.

Hendrich, B; Hardeland, U; Ng, H H; Jiricny, J; Bird, A (1999). The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature, 401(6750):301-304.

Santoro, M M; Penengo, Lorenza; Minetto, M; Orecchia, S; Cilli, M; Gaudino, G (1998). Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor. Oncogene, 17(6):741-749.

Barrett, T E; Savva, R; Panayotou, G; Barlow, T; Brown, T; Jiricny, J; Pearl, L H (1998). Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell, 92(1):117-129.

Peghini, P A; Zahner, R; Kuster, H; Schott, H; Schwendener, R (1998). In vitro anti-human immunodeficiency virus and anti-hepatitis B virus activities and pharmacokinetic properties of heterodinucleoside phosphates containing AZT or ddC. Antiviral Chemistry & Chemotherapy, 9(2):117-126.

Marra, Giancarlo; Iaccarino, I; Lettieri, T; Roscilli, G; Delmastro, P; Jiricny, J (1998). Mismatch repair deficiency associated with overexpression of the MSH3 gene. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 95(15):8568-8573.

Rentsch, K M; Schwendener, R; Pestalozzi, B C; Sauter, C; Wunderli-Allenspach, H; Hänseler, E (1998). Pharmacokinetic studies of mitoxantrone and one of its metabolites in serum and urine in patients with advanced breast cancer. European Journal of Clinical Pharmacology, 54(1):83-89.

Jiricny, J (1998). Replication errors: cha(lle)nging the genome. The EMBO Journal, 17(22):6427-6436.

van Borssum Waalkes, M; Goris, H; Dontje, B H; Schwendener, R; Scherphof, G; Nijhof, W (1998). Toxicity of liposomal 3'-5'-O-dipalmitoyl-5-fluoro-2'-deoxyuridine in mice. Anti-Cancer Drug Design, 13(4):291-305.

Iaccarino, I; Marra, Giancarlo; Palombo, F; Jiricny, J (1998). hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha. The EMBO Journal, 17(9):2677-2686.

Rentsch, K M; Horber, D H; Schwendener, R; Wunderli-Allenspach, H; Hänseler, E (1997). Comparative pharmacokinetic and cytotoxic analysis of three different formulations of mitoxantrone in mice. British Journal of Cancer, 75(7):986-992.

Seiler, P; Aichele, P; Odermatt, B; Hengartner, H; Zinkernagel, R M; Schwendener, R (1997). Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection. European Journal of Immunology, 27(10):2626-2633.

Werner, C A; Döhner, H; Joos, S; Trümper, L H; Baudis, Michael; Barth, T F; Ott, G; Möller, P; Lichter, P; Bentz, M (1997). High-level DNA amplifications are common genetic aberrations in B-cell neoplasms. American Journal of Pathology, 151(2):335-342.

Koller-Lucae, S K; Schott, H; Schwendener, R (1997). Interactions with human blood in vitro and pharmacokinetic properties in mice of liposomal N4-octadecyl-1-beta-D-arabinofuranosylcytosine, a new anticancer drug. Journal of Pharmacology and Experimental Therapeutics, 282(3):1572-1580.

Frankenberger, M; Hofmann, B; Emmerich, B; Nerl, C; Schwendener, R; Ziegler-Heitbrock, H W (1997). Liposomal 1,25 (OH)2 vitamin D3 compounds block proliferation and induce differentiation in myelomonocytic leukaemia cells. British Journal of Haematology, 98(1):186-194.

Rentsch, K M; Schwendener, R; Schott, H; Hänseler, E (1997). Pharmacokinetics of N4-octadecyl-1-beta-D-arabinofuranosylcytosine in plasma and whole blood after intravenous and oral administration to mice. Journal of Pharmacy and Pharmacology, 49(11):1076-1081.

Gallinari, P; Jiricny, J (1996). A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase. Nature, 383(6602):735-738.

Neddermann, P; Gallinari, P; Lettieri, T; Schmid, D; Truong, O; Hsuan, J J; Wiebauer, K; Jiricny, J (1996). Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. Journal of Biological Chemistry, 271(22):12767-12774.

Rentsch, K M; Schwendener, R; Hänseler, E (1996). Determination of mitoxantrone in mouse whole blood and different tissues by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 679(1-2):185-192.

Müller, Anne; Hacker, J; Brand, B C (1996). Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection. Infection and Immunity, 64(12):4900-4906.

Marra, Giancarlo; Chang, C L; Laghi, L A; Chauhan, D P; Young, D; Boland, C R (1996). Expression of human MutS homolog 2 (hMSH2) protein in resting and proliferating cells. Oncogene, 13(10):2189-2196.

Schwendener, R; Schott, H (1996). Lipophilic 1-beta-D-arabinofuranosyl cytosine derivatives in liposomal formulations for oral and parenteral antileukemic therapy in the murine L1210 leukemia model. Journal of Cancer Research and Clinical Oncology, 122(12):723-726.

Schwendener, R; Horber, D H; Odermatt, B; Schott, H (1996). Oral antitumour activity in murine L1210 leukaemia and pharmacological properties of liposome formulations of N4-alkyl derivatives of 1-beta-D-arabinofuranosylcytosine. Journal of Cancer Research and Clinical Oncology, 122(2):102-108.

Schott, H; Schwendener, R (1996). Synthesis and structure-activity studies in vivo of liposomal phospholipid-N4-palmitoyl- and N4-hexadecyl-1-beta-D-arabinofuranosylcytosine conjugates. Anti-Cancer Drug Design, 11(6):451-62.

Palombo, F; Iaccarino, I; Nakajima, E; Ikejima, M; Shimada, T; Jiricny, J (1996). hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Current Biology, 6(9):1181-1184.

Marra, Giancarlo; Boland, C R (1995). Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. Journal of the National Cancer Institute, 87(15):1114-1125.

Horber, D H; von Ballmoos, P; Schott, H; Schwendener, R (1995). Cell cycle-dependent cytotoxicity and induction of apoptosis by liposomal N4-hexadecyl-1-beta-D-arabinofuranosylcytosine. British Journal of Cancer, 72(5):1067-1073.

Horber, D H; Schott, H; Schwendener, R (1995). Cellular pharmacology of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine in the human leukemic cell lines K-562 and U-937. Cancer Chemotherapy and Pharmacology, 36(6):483-492.

Horber, D H; Schott, H; Schwendener, R (1995). Cellular pharmacology of a liposomal preparation of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine, a lipophilic derivative of 1-beta-D-arabinofuranosylcytosine. British Journal of Cancer, 71(5):957-962.

Palombo, F; Gallinari, P; Iaccarino, I; Lettieri, T; Hughes, M; D'Arrigo, A; Truong, O; Hsuan, J J; Jiricny, J (1995). GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science, 268(5219):1912-1914.

Horber, D H; Ottiger, C; Schott, H; Schwendener, R (1995). Pharmacokinetic properties and interactions with blood components of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC) incorporated into liposomes. Journal of Pharmacy and Pharmacology, 47(4):282-288.

Pestalozzi, B C; Vass, A; Adam, H; Horber, D H; Schwendener, R; Sauter, C (1995). Phase II study of liposome-complexed mitoxantrone in patients with advanced breast cancer. European Journal of Cancer, 31A(6):1024.

Rentsch, K M; Schwendener, R; Schott, H; Hänseler, E (1995). Sensitive high-performance liquid chromatographic method for the determination of N4-hexadecyl- and N4-octadecyl-1-beta-D-arabinofuranosylcytosine in plasma and erythrocytes. Journal of Chromatography B: Biomedical Sciences and Applications, 673(2):259-266.

Marra, Giancarlo; Anti, M; Percesepe, A; Armelao, F; Ficarelli, R; Coco, C; Rinelli, A; Vecchio, F M; D'Arcangelo, E (1994). Circadian variations of epithelial cell proliferation in human rectal crypts. Gastroenterology, 106(4):982-987.

Anti, M; Armelao, F; Marra, Giancarlo; Percesepe, A; Bartoli, G M; Palozza, P; Parrella, P; Canetta, C; Gentiloni, N; De Vitis, I (1994). Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Gastroenterology, 107(6):1709-1718.

Schwendener, R; Gowland, P; Horber, D H; Zahner, R; Schertler, A; Schott, H (1994). New lipophilic alkyl/acyl dinucleoside phosphates as derivatives of 3'-azido-3'-deoxythymidine: inhibition of HIV-1 replication in vitro and antiviral activity against Rauscher leukemia virus infected mice with delayed treatment regimens. Antiviral Research, 24(1):79-93.

Condrau, M A; Schwendener, R; Niederer, P; Anliker, M (1994). Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: I. Concept and theoretical evaluation. Cytometry Part A, 16(3):187-194.

Condrau, M A; Schwendener, R; Zimmermann, M; Muser, M H; Graf, U; Niederer, P; Anliker, M (1994). Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: II. Instrument design and experimental results. Cytometry Part A, 16(3):195-205.

Anti, M; Marra, Giancarlo; Armelao, F; Bartoli, G M; Ficarelli, R; Percesepe, A; De Vitis, I; Maria, G; Sofo, L; Rapaccini, G L (1992). Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. Gastroenterology, 103(3):883-891.

Pestalozzi, B; Schwendener, R; Sauter, C (1992). Phase I/II study of liposome-complexed mitoxantrone in patients with advanced breast cancer. Annals of Oncology, 3(6):445-449.

Schwendener, R; Schott, H (1992). Treatment of L1210 murine leukemia with liposome-incorporated N4-hexadecyl-1-beta-D-arabinofuranosyl cytosine. International Journal of Cancer, 51(3):466-469.

Schwendener, R; Fiebig, H H; Berger, M R; Berger, D P (1991). Evaluation of incorporation characteristics of mitoxantrone into unilamellar liposomes and analysis of their pharmacokinetic properties, acute toxicity, and antitumor efficacy. Cancer Chemotherapy and Pharmacology, 27(6):429-439.

Schwendener, R; Wüthrich, R; Duewell, S; Wehrli, E; von Schulthess, G K (1990). A pharmacokinetic and MRI study of unilamellar gadolinium-, manganese-, and iron-DTPA-stearate liposomes as organ-specific contrast agents. Investigative Radiology, 25(8):922-932.

Wiebauer, K; Jiricny, J (1989). In vitro correction of G.T mispairs to G.C pairs in nuclear extracts from human cells. Nature, 339(6221):234-236.

Brown, T C; Jiricny, J (1988). Different base/base mispairs are corrected with different efficiencies and specificities in monkey kidney cells. Cell, 54(5):705-711.

Brown, T C; Jiricny, J (1987). A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine. Cell, 50(6):945-950.

This list was generated on Fri Jul 12 23:58:35 2024 CEST.