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07 Faculty of Science > Department of Molecular Mechanisms of Disease"

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Mengis, Tamara. The Role of Intervertebral Disc Cartilage Catabolites in Modic Type 1 Changes. 2024, University of Zurich, Faculty of Science.

Böhi, Flurina. Unraveling the Function of PARP1 in Natural Killer Cell-Regulated Immune Signaling: PARP1 Mediates Cytokine Dependent T Cell Polarization and T Cell Tumor Infiltration. 2024, University of Zurich, Faculty of Science.

Manetsch, Patrick. PARP7 Regulates FRA1 Protein-Turnover and Thermostability: Implications for Cancer Progression and Treatment. 2024, University of Zurich, Faculty of Science.

Richter, Henning; Verlemann, Christine; Jeibmann, Astrid; Martin, Louise F; Luebke, Andreas M; Karol, Agnieszka; Sperling, Michael; Radbruch, Alexander; Karst, Uwe (2024). Elemental Bioimaging of Sheep Bone and Articular Cartilage After Single Application of Gadolinium-Based Contrast Agents. Investigative Radiology, 59(4):287-292.

Güldenpfennig, Anka. An Energetic Balancing Act: The Connection Between Mitochondrial and Nuclear NAD$^t{+}$ Pools Regulates ADP-Ribosylation During DNA Damage. 2024, University of Zurich, Faculty of Science.

Herger, Nick. Development of an Allogeneic, Anti-Inflammatory Bone Marrow Stromal Cell Therapy for Chronic Low Back Pain Patients with Modic Type 1 Changes. 2024, University of Zurich, Faculty of Science.

Meyer, Dominik C; Bachmann, Elias; Darwiche, Salim; Moehl, Andrea; von Rechenberg, Brigitte; Gerber, Christian; Snedeker, Jess G (2023). Rotator Cuff Repair and Overlay Augmentation by Direct Interlocking of a Nonwoven Polyethylene Terephthalate Patch Into the Tendon: Evaluation in an Ovine Model. American Journal of Sports Medicine, 51(12):3235-3242.

de Wild, Michael; Zimmermann, Simon; Klein, Karina; Steffen, Thomas; Schlottig, Falko; Hasler, Carol; von Rechenberg, Brigitte (2023). Immediate stabilization of pedicle screws: Preclinical pilot study of polymer-augmented pedicle screws. Current Directions in Biomedical Engineering, 9(1):13-16.

Krishnan, Aswini; Spegg, Vincent; Dettwiler, Susanne; Schraml, Peter; Moch, Holger; Dedes, Konstantin; Varga, Zsuzsanna; Altmeyer, Matthias (2023). Analysis of the PARP1, ADP-Ribosylation, and TRIP12 Triad With Markers of Patient Outcome in Human Breast Cancer. Modern Pathology, 36(7):100167.

Reiländer, Simon; Schmehl, Wolfgang; Popp, Kevin; Nuss, Katja; Kronen, Peter; Verdino, Dagmar; Wiezorek, Christina; Gutmann, Marcus; Hahn, Lukas; Däubler, Christof; Meining, Alexander; Raschig, Martina; Kaiser, Friederike; von Rechenberg, Brigitte; Scherf-Clavel, Oliver; Meinel, Lorenz (2023). Oral Use of Therapeutic Carbon Monoxide for Anyone, Anywhere, and Anytime. ACS Biomaterials Science & Engineering, 9(6):2937-2948.

Schraml, Peter; Aimi, Fabio; Zoche, Martin; Aguilera-Garcia, Domingo; Arnold, Fabian; Moch, Holger; Hottiger, Michael O (2023). Altered cytoplasmic and nuclear ADP-ribosylation levels analyzed with an improved ADP-ribose binder are a prognostic factor in renal cell carcinoma. Journal of Pathology: Clinical Research, 9(4):273-284.

Lehner, Felix. A study on the efficacy of a lentiviral vector for treatment of immunodeficiency in a mouse disease model. 2023, University of Zurich, Vetsuisse Faculty.

Schleich, Sarah Christina Angelika. Effects of shape and structure of a new 3D-printed personalized bioresorbable tracheal stent on fit and biocompatibility in a rabbit model. 2023, University of Zurich, Vetsuisse Faculty.

Ross, Julius Ludwig. Magnesiumlegierungen und Implantate in der Kraniomaxillofazialen Chirurgie - eine Wirksamkeitsstudie bei Schafen. 2023, University of Zurich, Vetsuisse Faculty.

Elksnat, Anna-Lena; Zscherpe, Paula; Klein, Karina; Cavalleri, Jessika Maximiliane; Meißner, Jessica (2022). Effect of an Oxygen-Based Mechanical Drug Delivery System on Percutaneous Permeation of Various Substances In Vitro. Pharmaceutics, 14(12):2722.

Lüscher, Bernhard; Ahel, Ivan; Altmeyer, Matthias; Ashworth, Alan; Bai, Peter; Chang, Paul; et al; Hottiger, Michael O (2022). ADP‐ribosyltransferases, an update on function and nomenclature. FEBS Journal, 289(23):7399-7410.

Lädermann, Alexandre; Gehrke, Rieke; Klein, Karina; Karol, Agnieszka; Darwiche, Salim; Schwarzenberg, Peter; Steffen, Thomas; Wieser, Karl; Kronen, Peter; von Rechenberg, Brigitte (2022). Studying Edema Formation After Release of the Infraspinatus Tendon as an Experimental Model of Rotator Cuff Tears in Sheep: A Preliminary Imaging and Morphological Analysis. American Journal of Sports Medicine, 50(14):3934-3940.

Mosler, Thorsten; Baymaz, H Irem; Gräf, Justus F; Mikicic, Ivan; Blattner, Georges; Bartlett, Edward; Ostermaier, Matthias; Piccinno, Rossana; Yang, Jiwen; Voigt, Andrea; Gatti, Marco; Pellegrino, Stefania; Altmeyer, Matthias; Luck, Katja; Ahel, Ivan; Roukos, Vassilis; Beli, Petra (2022). PARP1 proximity proteomics reveals interaction partners at stressed replication forks. Nucleic Acids Research, 50(20):11600-11618.

Rüger, Matthias; Seitz, Andreas Martin; Nuss, Katja; von Rechenberg, Brigitte; Seitz, Daniel; Kostmann, Cris; Quadbeck, Peter; Andersen, Olaf; Collins, Caitlyn (2022). A Bioinspired Orthopedic Biomaterial with Tunable Mechanical Properties Based on Sintered Titanium Fibers. Advanced Healthcare Materials, 12(2):e2202106.

Cereghetti, Alessandra. Targeting DNA Methylation to Modulate Immunogenicity in Cutaneous Melanoma. 2022, University of Zurich, Vetsuisse Faculty.

Kuraoka, Shiori; Higashi, Hideyuki; Yanagihara, Yoshihiro; Sonawane, Abhijeet R; Mukai, Shin; Mlynarchik, Andrew K; Whelan, Mary C; Hottiger, Michael O; Nasir, Waqas; Delanghe, Bernard; Aikawa, Masanori; Singh, Sasha A (2022). A Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ. Molecular & Cellular Proteomics, 21(4):100153.

Feusi, Oscar; Karol, Agnieszka; Fleischmann, Thea; von Rechenberg, Brigitte; Bouaicha, Samy; Werner, Clement M L; Jentzsch, Thorsten (2022). Platelet-rich plasma as a potential prophylactic measure against frozen shoulder in an in vivo shoulder contracture model. Archives of Orthopaedic and Trauma Surgery, 142(3):363-372.

Frese, Laura; Darwiche, Salim Elias; Gunning, Myrna Elisabeth; Hoerstrup, Simon Philipp; von Rechenberg, Brigitte; Giovanoli, Pietro; Calcagni, Maurizio (2022). Optimizing large-scale autologous human keratinocyte sheets for major burns—Toward an animal-free production and a more accessible clinical application. Health Science Reports, 5(1):e449.

Yang, Bin; Borgeaud, Alicia C; Buřičová, Marcela; Aeschbach, Lorène; Rodríguez-Lima, Oscar; Ruiz Buendía, Gustavo A; Cinesi, Cinzia; Taylor, Alysha S; Baubec, Tuncay; Dion, Vincent (2022). Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing. Human Molecular Genetics, 31(3):386-398.

Dolert, Simon Walter. Biokompatibilitätsstudie von Magnesiumimplantaten im Beckenmodell des Schafes. 2022, University of Zurich, Vetsuisse Faculty.

Geks, Anna Karoline. Development of an animal model to induce airway stenosis and the placement of a 3D printed airway stent. 2022, University of Zurich, Vetsuisse Faculty.

Gehrke, Rieke. Grundlagenforschung zu Rotatorenmanschettenruptur in einem Schafmodell - Einfluss eines initialen Ödems nach einem Trauma auf die Muskeldegeneration. 2022, University of Zurich, Vetsuisse Faculty.

Yilmaz, Duygu; Furst, Audrey; Meaburn, Karen; Lezaja, Aleksandra; Wen, Yanlin; Altmeyer, Matthias; Reina-San-Martin, Bernardo; Soutoglou, Evi (2021). Activation of homologous recombination in G1 preserves centromeric integrity. Nature, 600(7890):748-753.

Panagopoulos, Andreas; Altmeyer, Matthias (2021). When the RAP (80) fades out, you can hear BRCA1 RING. EMBO Reports, 22(12):e54116.

Levinson, Clara; Cavalli, Emma; von Rechenberg, Brigitte; Zenobi-Wong, Marcy; Darwiche, Salim E (2021). Combination of a Collagen Scaffold and an Adhesive Hyaluronan-Based Hydrogel for Cartilage Regeneration: A Proof of Concept in an Ovine Model. Cartilage, 13(2_suppl):636S-649S.

Boehi, Flurina; Manetsch, Patrick; Hottiger, Michael O (2021). Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses. Cell Discovery, 7(1):104.

Lezaja, Aleksandra; Panagopoulos, Andreas; Wen, Yanlin; Carvalho, Edison; Imhof, Ralph; Altmeyer, Matthias (2021). RPA shields inherited DNA lesions for post-mitotic DNA synthesis. Nature Communications, 12(1):3827.

Peña‐Hernández, Rodrigo; Aprigliano, Rossana; Carina Frommel, Sandra; Pietrzak, Karolina; Steiger, Seraina; Roganowicz, Marcin; Lerra, Luigi; Bizzarro, Juliana; Santoro, Raffaella (2021). BAZ2A‐mediated repression via H3K14ac‐marked enhancers promotes prostate cancer stem cells. EMBO Reports, 22(11):e53014.

Spegg, Vincent; Altmeyer, Matthias (2021). Biomolecular condensates at sites of DNA damage: More than just a phase. DNA repair, 106:103179.

Häuselmann, Salome. Functional Analysis of PARP1 in Human Natural Killer Cells. 2021, University of Zurich, Vetsuisse Faculty.

Beltrán Bernal, Lina M; Canbaz, Ferda; Darwiche, Salim E; Nuss, Katja M R; Friederich, Niklaus F; Cattin, Philippe C; Zam, Azhar (2021). Optical fibers for endoscopic high-power Er:YAG laserosteotomy. Journal of Biomedical Optics, 26(09):095002-1.

Cambria, Elena; Heusser, Sally; Scheuren, Ariane C; Tam, Wai Kit; Karol, Agnieszka A; Hitzl, Wolfgang; Leung, Victor Y; Müller, Ralph; Ferguson, Stephen J; Wuertz-Kozak, Karin (2021). TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs. JOR Spine, 4(3):e1149.

Leutert, Mario; Duan, Yinghui; Winzer, Riekje; Menzel, Stephan; Tolosa, Eva; Magnus, Tim; Hottiger, Michael O; Koch-Nolte, Friedrich; Rissiek, Björn (2021). Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation. Frontiers in Immunology, 12:703719.

Diener, Johanna; Baggiolini, Arianna; Pernebrink, Mattias; Dalcher, Damian; Lerra, Luigi; Cheng, Phil F; Varum, Sandra; Häusel, Jessica; Stierli, Salome; Treier, Mathias; Studer, Lorenz; Basler, Konrad; Levesque, Mitchell P; Dummer, Reinhard; Santoro, Raffaella; Cantù, Claudio; Sommer, Lukas (2021). Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4. Nature Communications, 12(1):5056.

Lüthi, Stephanie C; Howald, Anna; Nowak, Kathrin; Graage, Robert; Bartolomei, Giody; Neupert, Christine; Sidler, Xaver; Leslie Pedrioli, Deena; Hottiger, Michael O (2021). Establishment of a mass-spectrometry-based method for the identification of the in vivo whole blood and plasma ADP-Ribosylomes. Journal of Proteome Research, 20(6):3090-3101.

Ghodke, Indrajeet; Remisova, Michaela; Furst, Audrey; Kilic, Sinan; Reina-San-Martin, Bernardo; Poetsch, Anna R; Altmeyer, Matthias; Soutoglou, Evi (2021). AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation. Molecular Cell, 81(12):2596-2610.e7.

Michelena, Jone; Pellegrino, Stefania; Spegg, Vincent; Altmeyer, Matthias (2021). Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells. Life Science Alliance, 4(6):e202101023.

Parnandi, Nishita; Rendo, Veronica; Cui, Gaofeng; Botuyan, Maria Victoria; Remisova, Michaela; Nguyen, Huy; Drané, Pascal; Beroukhim, Rameen; Altmeyer, Matthias; Mer, Georges; Chowdhury, Dipanjan (2021). TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs. Molecular Cell, 81(12):2583-2595.e6.

Scarborough, Joseph; Mueller, Flavia S; Weber-Stadlbauer, Ulrike; Mattei, Daniele; Opitz, Lennart; Cattaneo, Annamaria; Richetto, Juliet (2021). A novel murine model to study the impact of maternal depression and antidepressant treatment on biobehavioral functions in the offspring. Molecular Psychiatry, 26(11):6756-6772.

Bisceglie, Lavinia; Hopp, Ann-Katrin; Gunasekera, Kapila; Wright, Roni H; Le Dily, François; Vidal, Enrique; Dall’Agnese, Alessandra; Caputo, Luca; Nicoletti, Chiara; Puri, Pier Lorenzo; Beato, Miguel; Hottiger, Michael O (2021). MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation. iScience, 24(5):102432.

Laurent, Alexis; Abdel-Sayed, Philippe; Grognuz, Anthony; Scaletta, Corinne; Hirt-Burri, Nathalie; Michetti, Murielle; de Buys Roessingh, Anthony S; Raffoul, Wassim; Kronen, Peter; Nuss, Katja; von Rechenberg, Brigitte; Applegate, Lee Ann; Darwiche, Salim E (2021). Industrial Development of Standardized Fetal Progenitor Cell Therapy for Tendon Regenerative Medicine: Preliminary Safety in Xenogeneic Transplantation. Biomedicines, 9(4):380.

Schwarzenberg, Peter; Klein, Karina; Ferguson, Stephen J; von Rechenberg, Brigitte; Darwiche, Salim; Dailey, Hannah L (2021). Virtual mechanical tests out‐perform morphometric measures for assessment of mechanical stability of fracture healing in vivo. Journal of Orthopaedic Research, 39(4):727-738.

Hopp, Ann-Katrin; Hottiger, Michael O (2021). Uncovering the invisible: Mono-ADP-ribosylation moved into the spotlight. Cells, 10(3):680.

Roeschert, Isabelle; Poon, Evon; Henssen, Anton G; Dorado Garcia, Heathcliff; Gatti, Marco; Giansanti, Celeste; Jamin, Yann; Ade, Carsten P; Gallant, Peter; Schülein-Völk, Christina; Beli, Petra; Richards, Mark; Rosenfeldt, Mathias; Altmeyer, Matthias; Anderson, John; Eggert, Angelika; Dobbelstein, Matthias; Bayliss, Richard; Chesler, Louis; Büchel, Gabriele; Eilers, Martin (2021). Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma. Nature Cancer, 2(3):312-326.

Laurent, Alexis; Abdel-Sayed, Philippe; Ducrot, Aurélie; Hirt-Burri, Nathalie; Scaletta, Corinne; Jaccoud, Sandra; Nuss, Katja; de Buys Roessingh, Anthony S; Raffoul, Wassim; Pioletti, Dominique; von Rechenberg, Brigitte; Applegate, Lee Ann; Darwiche, Salim (2021). Development of Standardized Fetal Progenitor Cell Therapy for Cartilage Regenerative Medicine: Industrial Transposition and Preliminary Safety in Xenogeneic Transplantation. Biomolecules, 11(2):250.

Poupart, Oriane; Conti, Riccardo; Schmocker, Andreas; Pancaldi, Lucio; Moser, Christophe; Nuss, Katja M; Sakar, Mahmut S; Dobrocky, Tomas; Grützmacher, Hansjörg; Mosimann, Pascal J; Pioletti, Dominique P (2021). Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms. Frontiers in Bioengineering and Biotechnology, 8:619858.

Gehrig, Peter M; Nowak, Kathrin; Panse, Christian; Leutert, Mario; Grossmann, Jonas; Schlapbach, Ralph; Hottiger, Michael O (2021). Gas-Phase Fragmentation of ADP-Ribosylated Peptides: Arginine-Specific Side-Chain Losses and Their Implication in Database Searches. Journal of the American Society for Mass Spectrometry, 32(1):157-168.

Paro, Renato; Grossniklaus, Ueli; Santoro, Raffaella; Wutz, Anton Introduction to Epigenetics. Edited by: Paro, Renato; Santoro, Raffaella; Grossniklaus, Ueli; Wutz, Anton (2021). Cham, Schweiz: Springer Verlag.

Hopp, Ann-Katrin; Hottiger, Michael O (2021). Investigation of Mitochondrial Via Immunofluorescence. In: Weissig, V; Edeas, M. Mitochondiral Medicine. New York: Springer, 165-171.

Hopp, Ann-Katrin; Teloni, Federico; Bisceglie, Lavinia; Gondrand, Corentin; Raith, Fabio; Nowak, Kathrin; Muskalla, Lukas; Howald, Anna; Pedrioli, Patrick G A; Johnsson, Kai; Altmeyer, Matthias; Pedrioli, Deena M Leslie; Hottiger, Michael O (2021). Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation. Molecular Cell, 81(2):340-354.e5.

Bersaglieri, Cristiana. Analysis of the Nucleolus in Genome Organization and Function. 2021, University of Zurich, Vetsuisse Faculty.

Lezaja, Aleksandra. Causes and Consequences of Replication Born Heritable DNA Lesions. 2021, University of Zurich, Vetsuisse Faculty.

Tegelkamp, Milena. Comparison of different viscosupplements to prevent the onset and progression of osteoarthritis – an efficacy study in an ovine femoroacetabular impingement model. 2021, University of Zurich, Vetsuisse Faculty.

Schmolka, Nina; Bhaskaran, Jahnavi; Karemaker, Ino D; Baubec, Tuncay (2021). Dissecting the roles of MBD2 isoforms in regulating NuRD complex function during cellular differentiation. bioRxiv 435677, Cold Spring Harbor Laboratory.

Finck, Konrad. Erforschung der Folgen einer Tenotomie und Neurotomie im Muskel am Rotatorenmanschettenmodell beim Schaf und die Auswirkung auf die Muskelphysiologie durch Prednisolon nach einer Tenotomie. 2021, University of Zurich, Vetsuisse Faculty.

Michalik, David. Osteoinduktion und Osseointegration von Titanimplantaten im Ratten- und Schafmodell. 2021, University of Zurich, Vetsuisse Faculty.

Villaseñor, Rodrigo; Baubec, Tuncay (2021). Regulatory mechanisms governing chromatin organization and function. Current Opinion in Cell Biology, 70:10-17.

Roganowicz, Marcin. The Analysis of the RNA-Interacting BAZ2A-TAM Domain in Prostate Cancer. 2021, University of Zurich, Vetsuisse Faculty.

Schlote, Marie-Therese. Verstärkte Fixierung von Pedikelschrauben: Einfluss der BoneWelding® Technologie auf die Biokompatibilität in der akuten bis frühen Heilungsphase. 2021, University of Zurich, Vetsuisse Faculty.

Cheng, Donghang; Gao, Guozhen; Di Lorenzo, Alessandra; Jayne, Sandrine; Hottiger, Michael O; Richard, Stephane; Bedford, Mark T (2020). Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6. Journal of Biological Chemistry, 295(50):17060-17070.

Dalcher, Damian; Tan, Jennifer Yihong; Bersaglieri, Cristiana; Peña-Hernández, Rodrigo; Vollenweider, Eva; Zeyen, Stefan; Schmid, Marc W; Bianchi, Valerio; Butz, Stefan; Roganowicz, Marcin; Kuzyakiv, Rostyslav; Baubec, Tuncay; Marques, Ana Claudia; Santoro, Raffaella (2020). BAZ2A safeguards genome architecture of ground-state pluripotent stem cells. EMBO Journal Online, 39(23):e105606.

Glaus Garzon, Jesus F; Pastrello, Chiara; Jurisica, Igor; Hottiger, Michael O; Wenger, Roland H; Borsig, Lubor (2020). Tumor cell endogenous HIF-1α activity induces aberrant angiogenesis and interacts with TRAF6 pathway required for colorectal cancer development. Neoplasia, 22(12):745-758.

Plecko, Michael; Klein, Karina; Planzer, Katrin; Wähnert, Dirk; Behm, Pascal; Ferguson, Stephen J; Brianza, Stefano; Stadelmann, Vincent A; von Rechenberg, Brigitte (2020). Variable fixation promotes callus formation: an experimental study on transverse tibial osteotomies stabilized with locking plates. BMC Musculoskeletal Disorders, 21:806.

Rother, Magdalena B; Pellegrino, Stefania; Smith, Rebecca; Gatti, Marco; Meisenberg, Cornelia; Wiegant, Wouter W; Luijsterburg, Martijn S; Imhof, Ralph; Downs, Jessica A; Vertegaal, Alfred C O; Huet, Sébastien; Altmeyer, Matthias; van Attikum, Haico (2020). CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks. Nature Communications, 11(1):5775.

Niu, Yiying; Yang, Lingguang; Gao, Teng; Dong, Changpeng; Zhang, Buyu; Yin, Peipei; Hopp, Ann-Katrin; Li, Dongdong; Gan, Rui; Wang, Hongou; Liu, Xi; Cao, Xueli; Xie, Yongchao; Meng, Xianbin; Deng, Haiteng; Zhang, Xiaohui; Ren, Jie; Hottiger, Michael O; Chen, Zeliang; Zhang, Yi; Liu, Xiaoyun; Feng, Yue (2020). A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation. Molecular Cell, 80(3):512-524.e5.

Walser, Franziska; Mulder, Monique P C; Bragantini, Benoît; Burger, Sibylle; Gubser, Tatiana; Gatti, Marco; Botuyan, Maria Victoria; Villa, Alessandra; Altmeyer, Matthias; Neri, Dario; Ovaa, Huib; Mer, Georges; Penengo, Lorenza (2020). Ubiquitin phosphorylation at Thr12 modulates the DNA damage response. Molecular Cell, 80(3):423-436.e9.

Nowak, Kathrin; Rosenthal, Florian; Karlberg, Tobias; Bütepage, Mareike; Thorsell, Ann-Gerd; Dreier, Birgit; Grossmann, Jonas; Sobek, Jens; Imhof, Ralph; Lüscher, Bernhard; Schüler, Herwig; Plückthun, Andreas; Leslie Pedrioli, Deena M; Hottiger, Michael O (2020). Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins. Nature Communications, 11:5199.

Berti, Matteo; Teloni, Federico; Mijic, Sofija; Ursich, Sebastian; Fuchs, Jevgenij; Palumbieri, Maria Dilia; Krietsch, Jana; Schmid, Jonas A; Garcin, Edwige B; Gon, Stéphanie; Modesti, Mauro; Altmeyer, Matthias; Lopes, Massimo (2020). Sequential role of RAD51 paralog complexes in replication fork remodeling and restart. Nature Communications, 11(1):3531.

Ruiz Buendía, Gustavo A; Leleu, Marion; Marzetta, Flavia; Vanzan, Ludovica; Tan, Jennifer Y; Ythier, Victor; Randall, Emma L; Marques, Ana C; Baubec, Tuncay; Murr, Rabih; Xenarios, Ioannis; Dion, Vincent (2020). Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion. Science Advances, 6(27):eaaz4012.

Ambrosi, Christina. Exploring the Functional Role of SETD2/H3K36me3 during Cellular Differentiation. 2020, University of Zurich, Vetsuisse Faculty.

Schwarzenberg, Peter; Darwiche, Salim; Yoon, Richard S; Dailey, Hannah L (2020). Imaging Modalities to Assess Fracture Healing. Current Osteoporosis Reports, 18(3):169-179.

Villaseñor, Rodrigo; Pfaendler, Ramon; Ambrosi, Christina; Butz, Stefan; Giuliani, Sara; Bryan, Elana; Sheahan, Thomas W; Gable, Annika L; Schmolka, Nina; Manzo, Massimiliano; Wirz, Joël; Feller, Christian; von Mering, Christian; Aebersold, Ruedi; Voigt, Philipp; Baubec, Tuncay (2020). ChromID identifies the protein interactome at chromatin marks. Nature Biotechnology, 38(6):728-736.

Villaseñor, Rodrigo; Pfaendler, Ramon; Ambrosi, Christina; Butz, Stefan; Giuliani, Sara; Bryan, Elana; Sheahan, Thomas W; Gable, Annika L; Schmolka, Nina; Manzo, Massimiliano; Wirz, Joël; Feller, Christian; von Mering, Christian; Aebersold, Ruedi; Voigt, Philipp; Baubec, Tuncay (2020). Publisher Correction: ChromID identifies the protein interactome at chromatin marks. Nature Biotechnology, 38(6):757.

Laurent, Alexis; Darwiche, Salim E; Hirt-Burri, Nathalie; Scaletta, Corinne; Michetti, Murielle; Laurent, Philippe; Raffoul, Wassim; de Buys Roessingh, Anthony S; Applegate, Lee Ann (2020). Banking Progenitor Cells for Hippiatric Regenerative Medicine: Optimized Establishment of Safe and Consistent Cell Sources for Standardized Veterinary Therapeutic Protocols. American Journal of Biomedical Science, 8(4):252-271.

Ashok, Yashwanth; Miettinen, Moona; De Oliveira, Danilo Kimio Hirabae; Tamirat, Mahlet Z; Näreoja, Katja; Tiwari, Avlokita; Hottiger, Michael O; Johnson, Mark S; Lehtiö, Lari; Pulliainen, Arto T (2020). Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin. ACS Infectious Diseases, 6(4):588-602.

Poupart, Oriane; Schmocker, Andreas; Conti, Riccardo; Moser, Christophe; Nuss, Katja M; Grützmacher, Hansjörg; Mosimann, Pascal J; Pioletti, Dominique P (2020). In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial Aneurysms. Frontiers in Bioengineering and Biotechnology, 8:261.

Wang, Chun; Xiao, Jianqiu; Nowak, Kathrin; Gunasekera, Kapila; Alippe, Yael; Speckman, Sheree; Yang, Tong; Kress, Dustin; Abu-Amer, Yousef; Hottiger, Michael O; Mbalaviele, Gabriel (2020). PARP1 hinders histone H2B occupancy at the NFATc1 promoter to restrain osteoclast differentiation. Journal of Bone and Mineral Research, 35(4):776-788.

Ringel, Till; Frey, Nina; Ringnalda, Femke; Janjuha, Sharan; Cherkaoui, Sarah; Butz, Stefan; Srivatsa, Sumana; Pirkl, Martin; Russo, Giancarlo; Villiger, Lukas; Rogler, Gerhard; Clevers, Hans; Beerenwinkel, Niko; Zamboni, Nicola; Baubec, Tuncay; Schwank, Gerald (2020). Genome-scale CRISPR screening in human intestinal organoids identifies drivers of TGF-β resistance. Cell Stem Cell, 26(3):431-440.e8.

Voelter, Katrin; Tappeiner, Christoph; Riond, Barbara; Nuss, Katja; Bruetsch, Deborah; Pot, Simon A (2020). Evaluation of D‐dimer levels in aqueous humor of rabbit eyes with and without induced intraocular fibrin and fibrinolytic treatment. Veterinary Ophthalmology, 23(2):212-218.

Bazzichetto, Chiara; Conciatori, Fabiana; Luchini, Claudio; Simionato, Francesca; Santoro, Raffaela; Vaccaro, Vanja; Corbo, Vincenzo; Falcone, Italia; Ferretti, Gianluigi; Cognetti, Francesco; Melisi, Davide; Scarpa, Aldo; Ciuffreda, Ludovica; Milella, Michele (2020). From Genetic Alterations to Tumor Microenvironment: The Ariadne’s String in Pancreatic Cancer. Cells, 9(2):309.

Arsiwala, Tasneem; Pahla, Jürgen; van Tits, Lambertus J; Bisceglie, Lavinia; Gaul, Daniel S; Costantino, Sarah; Miranda, Melroy X; Nussbaum, Kathrin; Stivala, Simona; Blyszczuk, Przemyslaw; Weber, Julien; Tailleux, Anne; Stein, Sokrates; Paneni, Francesco; Beer, Jürg H; Greter, Melanie; Becher, Burkhard; Mostoslavsky, Raul; Eriksson, Urs; Staels, Bart; Auwerx, Johan; Hottiger, Michael O; Lüscher, Thomas F; Matter, Christian M (2020). Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1. Journal of Molecular and Cellular Cardiology, 139:24-32.

Santoro, Raffaela; Zanotto, Marco; Simionato, Francesca; Zecchetto, Camilla; Merz, Valeria; Cavallini, Chiara; Piro, Geny; Sabbadini, Fabio; Boschi, Federico; Scarpa, Aldo; Melisi, Davide (2020). Modulating TAK1 Expression Inhibits YAP and TAZ Oncogenic Functions in Pancreatic Cancer. Molecular Cancer Therapeutics, 19(1):247-257.

Merz, Valeria; Zecchetto, Camilla; Simionato, Francesca; Cavaliere, Alessandro; Casalino, Simona; Pavarana, Michele; Giacopuzzi, Simone; Bencivenga, Maria; Tomezzoli, Anna; Santoro, Raffaela; Fedele, Vita; Contarelli, Serena; Rossi, Irene; Giacomazzi, Serena; Pasquato, Martina; Piazzola, Cristiana; Milleri, Stefano; de Manzoni, Giovanni; Melisi, Davide (2020). A phase II trial of the FGFR inhibitor pemigatinib in patients with metastatic esophageal-gastric junction/gastric cancer trastuzumab resistant: the FiGhTeR trial. Therapeutic Advances in Medical Oncology, 12:1758835920937889.

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Kaczmarek, Anna. Effect of pulsed electromagnetic field therapy on bone repair and regeneration in two tibia osteotomy models in sheep. 2020, University of Zurich, Vetsuisse Faculty.

Siwy, Katharina. Entwicklung eines Tiermodells für eine akute Osteomyelitis im Schaf. 2020, University of Zurich, Vetsuisse Faculty.

Wiezorek, Christina. Evaluation eines neuen Biomaterials aus Carboxymethylcellulose zur Augmentation von Weichteilgewebe – eine Pilotstudie in Minipigs. 2020, University of Zurich, Vetsuisse Faculty.

Arz, Raphael. Evaluation of the efficacy of an augmentation material for peri-implant bone diseases in minipigs. 2020, University of Zurich, Vetsuisse Faculty.

Lüthi, Stephanie. Identification of the whole blood protein ADP-ribosylome under sepsis conditions in pigs. 2020, University of Zurich, Vetsuisse Faculty.

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Vdovenko, Daria; Bachmann, Marta; Wijnen, Winandus J; Hottiger, Michael O; Eriksson, Urs; Valaperti, Alan (2020). The adaptor protein c-Cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF-κB pathway. International immunopharmacology, 87:106822.

Morel, Sandrine; Karol, Agnieszka; Graf, Vanessa; Pelli, Graziano; Richter, Henning; Sutter, Esther; Braunersreuther, Vincent; Frösen, Juhana; Bijlenga, Philippe; Kwak, Brenda R; Nuss, Katja M (2019). Sex-related differences in wall remodeling and intraluminal thrombus resolution in a rat saccular aneurysm model. Journal of neurosurgery:1-14.

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Thorat, Nanasaheb D; Tofail, Syed A M; von Rechenberg, Brigitte; Townley, Helen; Brennan, Grace; Silien, Christophe; Yadav, Hemraj M; Steffen, Thomas; Bauer, Joanna (2019). Physically stimulated nanotheranostics for next generation cancer therapy: Focus on magnetic and light stimulations. Applied physics reviews, 6(4):041306.

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Michelena, Jone; Gatti, Marco; Teloni, Federico; Imhof, Ralph; Altmeyer, Matthias (2019). Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions. Journal of Cell Biology, 218(9):2865-2875.

Suter, Aline; Spirig, José Miguel; Fornaciari, Paolo; Bachmann, Elias; Götschi, Tobias; Klein, Karina; Farshad, Mazda (2019). Watertightness of wound closure in lumbar spine-a comparison of different techniques. Journal of spine surgery, 5(3):358-364.

Hopp, Ann-Katrin; Grüter, Patrick; Hottiger, Michael O (2019). Regulation of Glucose Metabolism by NAD$^{+}$ and ADP-Ribosylation. Cells, 8(8):pii: E890.

Xu, Yue; Zhou, Ping; Cheng, Sen; Lu, Qiuhe; Nowak, Kathrin; Hopp, Ann-Katrin; Li, Lin; Shi, Xuyan; Zhou, Zhiwei; Gao, Wenqing; Li, Da; He, Huabin; Liu, Xiaoyun; Ding, Jingjin; Hottiger, Michael O; Shao, Feng (2019). A bacterial effector reveals the V-ATPase-ATG16L1 axis that initiates xenophagy. Cell, 178(3):552-566.e20.

Kilic, Sinan; Lezaja, Aleksandra; Gatti, Marco; Bianco, Eliana; Michelena, Jone; Imhof, Ralph; Altmeyer, Matthias (2019). Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments. EMBO Journal Online, 38(16):e101379.

Pu, Wei-Ling; Bai, Ru-Yu; Zhou, Kun; Peng, Yan-Fei; Zhang, Meng-Ying; Hottiger, Michael O; Li, Wen-Hua; Gao, Xiu-Mei; Sun, Li-Kang (2019). Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation. International immunopharmacology, 72:204-210.

Zurmühle, C A; Schmaranzer, F; Nuss, Katja M; Wolfer, N; Ryan, M K; Zheng, G; von Rechenberg, Brigitte; Tannast, M (2019). Proof of concept: hip joint damage occurs at the zone of femoroacetabular impingement (FAI) in an experimental FAI sheep model. Osteoarthritis and Cartilage, 27(7):1075-1083.

Zhao, Weitian; Michalik, David; Ferguson, Stephen; Hofstetter, Willy; Lemaître, Jacques; von Rechenberg, Brigitte; Bowen, Paul (2019). Rapid evaluation of bioactive Ti-based surfaces using an in vitro titration method. Nature Communications, 10(1):2062.

Higashi, Hideyuki; Maejima, Takashi; Lee, Lang Ho; Yamazaki, Yukiyoshi; Hottiger, Michael O; Singh, Sasha A; Aikawa, Masanori (2019). A study into the ADP-ribosylome of IFN-γ-stimulated THP-1 human macrophage-like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-ribosylation. Journal of Proteome Research, 18(4):1607-1622.

Hartl, Dominik; Krebs, Arnaud R; Grand, Ralph S; Baubec, Tuncay; Isbel, Luke; Wirbelauer, Christiane; Burger, Lukas; Schubeler, Dirk (2019). CG dinucleotides enhance promoter activity independent of DNA methylation. Genome Research, 29(4):554-563.

Kunze, Friedrich A; Bauer, Michael; Komuczki, Juliana; Lanzinger, Margit; Gunasekera, Kapila; Hopp, Ann-Katrin; Lehmann, Mareike; Becher, Burkhard; Müller, Anne; Hottiger, Michael O (2019). ARTD1 in myeloid cells controls the IL-12/18–IFN-γ axis in a model of sterile sepsis, chronic bacterial infection, and cancer. Journal of Immunology, 202(5):1406-1416.

Teloni, Federico; Michelena, Jone; Lezaja, Aleksandra; Kilic, Sinan; Ambrosi, Christina; Menon, Shruti; Dobrovolna, Jana; Imhof, Ralph; Janscak, Pavel; Baubec, Tuncay; Altmeyer, Matthias (2019). Efficient pre-mRNA cleavage prevents replication-stress-associated genome instability. Molecular Cell, 73(4):670-683.e12.

Tappeiner, Christoph; Voelter, Katrin; Klein, Karina; Borel, Nicole; Bruetsch, Deborah; Laguna Sanz, Fernando; Pot, Simon A (2019). Fibrinolytic capacity of desmoteplase compared to tissue plasminogen activator in rabbit eyes. Journal of Ocular Pharmacology and Therapeutics, 35(1):66-75.

Kunze, Friedrich A; Hottiger, Michael O (2019). Regulating Immunity via ADP-Ribosylation: Therapeutic Implications and Beyond. Trends in Immunology, 40(2):159-173.

Flück, Martin; Valdivieso, Paola; Ruoss, Severin; von Rechenberg, Brigitte; Benn, Mario C; Meyer, Dominik C; Wieser, Karl; Gerber, Christian (2019). Neurectomy preserves fast fibers when combined with tenotomy of infraspinatus muscle via upregulation of myogenesis. Muscle & Nerve, 59(1):100-107.

Peña-Hernández, Rodrigo A. Analysis of the epigenetic reader TIP5-BRD in prostate stem cells. 2019, University of Zurich, Faculty of Science.

Abraham, Boaz. Biocompatibility testing of coated titanium and ceramic implants in a pelvic model in sheep. 2019, University of Zurich, Vetsuisse Faculty.

Heckel, Isabel. Die Etablierung des Kaninchens als Tiermodell für Kniegelenkendoprothesen. 2019, University of Zurich, Vetsuisse Faculty.

Chantre, Christophe Olivier. Engineering biometric instructive materials for wound healing regeneration. 2019, University of Zurich, Faculty of Science.

Heygen, Martina. Evaluating the efficacy of DYNACORD™ suture. 2019, University of Zurich, Vetsuisse Faculty.

Arendt, Larissa Luisa. Femoroazetabuläres Impingement im Schafmodell: Korrelation von dGEMRIC und T2-Sequenzen mit histologischen und biochemischen Knorpelbefunden. 2019, University of Zurich, Vetsuisse Faculty.

Manzo, Massimiliano. Regulation of DNA methylation by the de novo DNA methyltransferase DNMT3A. 2019, University of Zurich, Faculty of Science.

Kaserer, Joya Marina. Remodeling des hyalinen Knorpels nach Setzen eines subchondralen Knochendefektes in der proximalen Metaphyse der Tibia: eine experimentelle Studie in Schafen. 2019, University of Zurich, Vetsuisse Faculty.

Planzer, Katrin. Variable fixation locking screw (VFLS): investigation of bone healing with a device intended to optimize strain and micromotion for each phase of fracture healing. 2019, University of Zurich, Vetsuisse Faculty.

Gao, Tian; Díaz-Hirashi, Zyanya; Verdeguer, Francisco (2018). Metabolic signaling into chromatin modifications in the regulation of gene expression. International Journal of Molecular Sciences, 19(12):4108.

Altmeyer, Matthias (2018). Cells take a break when they are TIARed. EMBO Reports:e47403.

Lopez-Garcia, Laura A; Demiray, Levent; Ruch-Marder, Sandra; Hopp, Ann-Katrin; Hottiger, Michael O; Helbling, Paul M; Pavlou, Maria P (2018). Validation of extracellular ligand–receptor interactions by Flow-TriCEPS. BMC Research Notes, 11(1):863.

Richter, Henning; Karol, Agnieszka Anna; Nuss, Katja M; Lenisa, Aymone; Bruellmann, Erika; Maudens, Stella-Saphira; Hoffmann, Heinrich; von Rechenberg, Brigitte; Kircher, Patrick R (2018). Comparison of hock- and footpad-injection as a prostate adenocarcinoma model in rats. BMC Veterinary Research, 14(1):327.

Wyck, Sarah; Herrera, Carolina; Requena, Cristina E; Bittner, Lilli; Hájková, Petra; Bollwein, Heiner; Santoro, Raffaella (2018). Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development. Epigenetics & Chromatin, 11(1):60.

Montaldo, Nicola; et al. Functions of alkyladenine DNA glycosylase in DNA repair and transcription. 2018, University of Zurich, Faculty of Science.

Tugues, Sonia; Amorim, Ana; Spath, Sabine; Martin-Blondel, Guillaume; Schreiner, Bettina; De Feo, Donatella; Lutz, Mirjam; Guscetti, Franco; Apostolova, Petya; Haftmann, Claudia; Hasselblatt, Peter; Núñez, Nicolás Gonzalo; Hottiger, Michael O; van den Broek, Maries; Manz, Markus G; Zeiser, Robert; Becher, Burkhard (2018). Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF–licensed myeloid cells. Science Translational Medicine, 10(469):eaat8410.

Klusmann, Ina; Wohlberedt, Kai; Magerhans, Anna; Teloni, Federico; Korbel, Jan O; Altmeyer, Matthias; Dobbelstein, Matthias (2018). Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication. Proceedings of the National Academy of Sciences of the United States of America, 115(48):E11311-E11320.

Przetocka, Sara; Porro, Antonio; Bolck, Hella A; Walker, Christina; Lezaja, Aleksandra; Trenner, Anika; von Aesch, Christine; Himmels, Sarah-Felicitas; D’Andrea, Alan D; Ceccaldi, Raphael; Altmeyer, Matthias; Sartori, Alessandro A (2018). CtIP-mediated fork protection synergizes with BRCA1 to suppress genomic instability upon DNA replication stress. Molecular Cell, 72(3):568-582.e6.

Pellegrino, Stefania. DNA double strand break repair in the chromatin context. 2018, University of Zurich, Faculty of Science.

Teloni, Federico. Defining cancer-specific alterations in genome integrity maintenance. 2018, University of Zurich, Faculty of Science.

Beer, Patricia; Knell, Sebastian Christoph; Steffen, T; Pozzi, Antonio; Park, B H (2018). An ex-vivo biomechanical comparison of tension band stabilization and screws and polymethylmethacrylae fixation for lumbar vertebral fractures and luxations in cats. In: 5th World Veterinary Orthopaedic Congress ESVOT-VOS and 19th ESVOT Congress, Barcelona, 12 September 2018 - 15 September 2018. Germeval Task, 147-148.

Richter, Henning; Kircher, Patrick R; Joerger, Fabiola B; Bruellmann, Erika; Dennler, Matthias (2018). Assessment of myocardial perfusion at rest and during stress using dynamic first-pass contrast-enhanced magnetic resonance imaging in healthy dogs. Frontiers in Veterinary Science, 5:211.

Michelena, Jone; Lezaja, Aleksandra; Teloni, Federico; Schmid, Thomas; Imhof, Ralph; Altmeyer, Matthias (2018). Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance. Nature Communications, 9(1):2678.

Leslie Pedrioli, Deena M; Leutert, Mario; Bilan, Vera; Nowak, Kathrin; Gunasekera, Kapila; Ferrari, Elena; Imhof, Ralph; Malmström, Lars; Hottiger, Michael O (2018). Comprehensive ADP‐ribosylome analysis identifies tyrosine as an ADP‐ribose acceptor site. EMBO Reports, 19(8):e45310.

Zingg, Daniel; Debbache, Julien; Peña-Hernández, Rodrigo; Antunes, Ana T; Schaefer, Simon M; Cheng, Phil F; Zimmerli, Dario; Haeusel, Jessica; Calçada, Raquel R; Tuncer, Eylul; Zhang, Yudong; Bossart, Raphaël; Wong, Kwok-Kin; Basler, Konrad; Dummer, Reinhard; Santoro, Raffaella; Levesque, Mitchell P; Sommer, Lukas (2018). EZH2-mediated primary cilium deconstruction drives metastatic melanoma formation. Cancer Cell, 34(1):69-84.

Markkanen, J; Väisänen, T; Penttilä, A; Muinonen, K (2018). Scattering and absorption in dense discrete random media of irregular particles. Optics letters, 43(12):2925-2928.

Altmeyer, Matthias (2018). The memory remains. Aging:1-2.

Wyck, Sarah Luisa. Analysis of oxidative stress in sperm in early embryonic development. 2018, University of Zurich, Faculty of Science.

Dalcher, Damian. Chromatin and epigenetic regulation in ground state pluripotency. 2018, University of Zurich, Faculty of Science.

Aprigliano, Rossana. Deciphering the molecular pathomechanisms of HUWE1-induced XLID. 2018, University of Zurich, Faculty of Science.

Kunze, Friedrich Alexander. Elucidating the function of ARTD1 in macrophages in vivo. 2018, University of Zurich, Faculty of Science.

Steigerwald, Alina. Femoroacetabuläres Impingement im Schafmodell: intraartikuläre Injektion von Hyaluronsäure als Präventivmassnahme gegen fortschreitende Coxarthrose. 2018, University of Zurich, Vetsuisse Faculty.

Manzo, Massimiliano; Ambrosi, Christina; Baubec, Tuncay (2018). Genome-wide profiling of DNA methyltransferases in mammalian cells. In: Vavouri, Tanya; Peinado, Miguel A. CpG Islands. Berlin, Germany: Springer, 157-174.

Lezaja, Aleksandra; Altmeyer, Matthias (2018). Inherited DNA lesions determine G1 duration in the next cell cycle. Cell Cycle, 17(1):24-32.

Abplanalp, Jeannette; Hopp, Ann-Katrin; Hottiger, Michael O (2018). Mono-ADP-Ribosylhydrolase Assays. In: Chang, Paul. ADP-ribosylation and NAD+ Utilizing Enzymes. Zürich: Springer, 205-213.

Leutert, Mario; Menzel, Stephan; Braren, Rickmer; Rissiek, Björn; Hopp, Ann-Katrin; Nowak, Kathrin; Bisceglie, Lavinia; Gehrig, Peter; Li, Hui; Zolkiewska, Anna; Koch-Nolte, Friedrich; Hottiger, Michael O (2018). Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme. Cell Reports, 24(7):1916-1929.e5.

Saitowitz, Serah Naomi. Tracking cells in osteochondral explants: a study on cartilage remodeling. 2018, University of Zurich, Vetsuisse Faculty.

Colombo, Daniele F; Burger, Lukas; Baubec, Tuncay; Schübeler, Dirk (2017). Binding of high mobility group A proteins to the mammalian genome occurs as a function of AT-content. PLoS Genetics, 13(12):e1007102.

Manzo, Massimiliano; Wirz, Joël; Ambrosi, Christina; Villaseñor, Rodrigo; Roschitzki, Bernd; Baubec, Tuncay (2017). Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands. EMBO Journal Online, 36(23):3421-3434.

Bosshard, Matthias; Aprigliano, Rossana; Gattiker, Cristina; Palibrk, Vuk; Markkanen, Enni; Hoff Backe, Paul; Pellegrino, Stefania; Raymond, F. Lucy; Froyen, Guy; Altmeyer, Matthias; Bjørås, Magnar; Dianov, Grigory L; van Loon, Barbara (2017). Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability. Scientific Reports, 7(1):15050.

Abplanalp, Jeannette; Leutert, Mario; Frugier, Emilie; Nowak, Kathrin; Feurer, Roxane; Kato, Jiro; Kistemaker, Hans V A; Filippov, Dmitri V; Moss, Joel; Caflisch, Amedeo; Hottiger, Michael O (2017). Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase. Nature Communications, 8(1):2055.

Graf, Urs; Casanova, Elisa A; Wyck, Sarah; Dalcher, Damian; Gatti, Marco; Vollenweider, Eva; Okoniewski, Michal J; Weber, Fabienne A; Patel, Sameera S; Schmid, Marc W; Li, Jiwen; Sharif, Jafar; Wanner, Guido A; Koseki, Haruhiko; Wong, Jiemin; Pelczar, Pawel; Penengo, Lorenza; Santoro, Raffaella; Cinelli, Paolo (2017). Corrigendum: Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nature Cell Biology, 19(8):1003.

Larsen, Sara C; Leutert, Mario; Bilan, Vera; Martello, Rita; Jungmichel, Stephanie; Young, Clifford; Hottiger, Michael O; Nielsen, Michael L (2017). Proteome-wide identification of in vivo ADP-ribose acceptor sites by liquid chromatography–tandem mass spectrometry. In: Tulin, Alexei V. Poly(ADP-Ribose) Polymerase. Switzerland: Springer, 149-162.

Graf, Urs; Casanova, Elisa A; Wyck, Sarah; Dalcher, Damian; Gatti, Marco; Vollenweider, Eva; Okoniewski, Michal J; Weber, Fabienne A; Patel, Sameera S; Schmid, Marc W; Li, Jiwen; Sharif, Jafar; Wanner, Guido A; Koseki, Haruhiko; Wong, Jiemin; Pelczar, Pawel; Penengo, Lorenza; Santoro, Raffaella; Cinelli, Paolo (2017). Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nature Cell Biology, 19(7):763-773.

Verdeguer, Francisco; Aouadi, Myriam (2017). Macrophage heterogeneity and energy metabolism. Experimental Cell Research, 360(1):35-40.

Hottiger, Michael O; De Carvalho, Daniel D; Bortoluci, Karina R; et al (2017). Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage. Scientific Reports, 7:41686.

Bisceglie, Lavinia; Bartolomei, Giody; Hottiger, Michael O (2017). ADP-ribose-specific chromatin-affinity purification for investigating genome-wide or locus-specific chromatin ADP-ribosylation. Nature Protocols, 12(9):1951-1961.

Roentgen, Anne Marie. ARH1 regulates LPS-induced iNOS expression. 2017, University of Zurich, Vetsuisse Faculty.

Hatting, Maximilian; Rines, Amy K; Luo, Chi; Tabata, Mitsuhisa; Sharabi, Kfir; Hall, Jessica A; Verdeguer, Francisco; Trautwein, Christian; Puigserver, Pere (2017). Adipose tissue CLK2 promotes energy expenditure during high-fat diet intermittent fasting. Cell Metabolism, 25(2):428-437.

Abplanalp, Jeannette. Biochemical and biological characterization of the ADP-Ribosylhydrolase 3. 2017, University of Zurich, Faculty of Science.

Arsiwala, Tasneem. Bone marrow-specific Sirt6 deficiency enhances atherosclerosis by increasing Macrophage scavenger receptor 1 expression. 2017, University of Zurich, Faculty of Science.

Michelena, Jone; Altmeyer, Matthias (2017). Cell cycle resolved measurements of poly(ADP-ribose) formation and DNA damage signaling by quantitative image-based cytometry. In: Tulin, Alexei V.. Poly(ADP-Ribose) Polymerase. New York: Springer, 57-68.

Abplanalp, Jeannette; Hottiger, Michael O (2017). Cell fate regulation by chromatin ADP-ribosylation. Seminars in Cell & Developmental Biology, 63:114-122.

Bilan, Vera; Leutert, Mario; Nanni, Paolo; Panse, Christian; Hottiger, Michael O (2017). Combining higher-energy collision dissociation and electron-transfer/higher-energy collision dissociation fragmentation in a product-dependent manner confidently assigns proteomewide adp-ribose acceptor sites. Analytical Chemistry, 89(3):1523-1530.

Duda, Heike; Arter, Meret; Gloggnitzer, Jiradet; Teloni, Federico; Wild, Philipp; Blanco, Miguel G; Altmeyer, Matthias; Matos, Joao (2017). Correction: A mechanism for controlled breakage of under-replicated chromosomes during mitosis. Developmental Cell, 40(4):421-422.

Ambrosi, Christina; Manzo, Massimiliano; Baubec, Tuncay (2017). Dynamics and context-dependent roles of DNA methylation. Journal of Molecular Biology, 429(10):1459-1475.

Rissiek, Björn; Menzel, Stephan; Leutert, Mario; Cordes, Maike; Behr, Sarah; Jank, Larissa; Ludewig, Peter; Gelderblom, Mathias; Rissiek, Anne; Adriouch, Sahil; Haag, Friedrich; Hottiger, Michael O; Koch-Nolte, Friedrich; Magnus, Tim (2017). Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia. Scientific Reports, 7(1):16477.

Kuhn, Julia. Epigenetic analysis of ribosomal RNA sequence heterogeneity in embryonic stem cells. 2017, University of Zurich, Vetsuisse Faculty.

Gaul, Daniel S. From caloric restriction to cardiovascular health: a protective role for Sirt3 and Sirt6 in atherothrombosis. 2017, University of Zurich, Faculty of Science.

Leutert, Mario; Bilan, Vera; Gehrig, Peter; Hottiger, Michael O (2017). Identification of ADP-Ribose acceptor sites on in vitro modified proteins by liquid chromatography–tandem mass spectrometry. Methods in Molecular Biology, 1608:137-148.

De Donato, Carlo; Barca, Donatella; Milazzo, Concetta; Santoro, Raffaella; Giglio, Gianni; Tripepi, Sandro; Sperone, Emilio (2017). Is trace element concentration correlated to parasite abundance? A case study in a population of the green frog Pelophylax synkl. hispanicus from the Neto River (Calabria, southern Italy). Parasitology Research, 116(6):1745-1753.

Bilan, Vera. Mass spectrometry-based methods for analyzing oxidative stress-mediated cellular ADP-ribosylation. 2017, University of Zurich, Faculty of Science.

Bilan, Vera; Selevsek, Nathalie; Kistemaker, Hans A. V; Abplanalp, Jeannette; Feurer, Roxane; Filippov, Dmitri V; Hottiger, Michael O (2017). New quantitative mass spectrometry approaches reveal different ADP-ribosylation phases dependent on the levels of oxidative stress. Molecular & Cellular Proteomics, 16(5):949-958.

Osorio Lujan, Suzanne Marie. Plasma concentrations of transdermal fentanyl and buprenorphine in pigs (Sus scropha domesticus). 2017, University of Zurich, Vetsuisse Faculty.

Leutert, Mario. Proteome-wide identification and characterization of protein ADP-ribosylation in mammalian cells and mouse tissues. 2017, University of Zurich, Faculty of Science.

Pellegrino, Stefania; Michelena, Jone; Teloni, Federico; Imhof, Ralph; Altmeyer, Matthias (2017). Replication-coupled dilution of H4K20me2 guides 53BP1 to pre-replicative chromatin. Cell Reports, 19(9):1819-1831.

Leone, Sergio; Bär, Dominik; Slabber, Coenraad Frederik; Dalcher, Damian; Santoro, Raffaella (2017). The RNA helicase DHX9 establishes nucleolar heterochromatin, and this activity is required for embryonic stem cell differentiation. EMBO Reports, 18(7):1248-1262.

Leone, Sergio. Establishment of Heterochromatin at rRNA Genes Is Required for Embryonic Stem Cells Differentiation. 2016, University of Zurich, Vetsuisse Faculty.

Bilan, Vera. Mass spectrometry-based methods for analyzing oxidative stress-mediated cellular adp-ribosylation. 2016, University of Zurich, Faculty of Science.

Böhm, Maria; Wachtel, Marco; Marques, Joana G; Streiff, Natalie; Laubscher, Dominik; Nanni, Paolo; Mamchaoui, Kamel; Santoro, Raffaella; Schäfer, Beat W (2016). Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma. Journal of Clinical Investigation, 126(11):4237-4249.

Martello, Rita; Leutert, Mario; Jungmichel, Stephanie; Bilan, Vera; Larsen, Sara C; Young, Clifford; Hottiger, Michael O; Nielsen, Michael L (2016). Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue. Nature Communications, 7:12917.

Léger, Karolin; Hopp, Ann-Katrin; Fey, Monika; Hottiger, Michael O (2016). ARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells. Cell Cycle, 15(15):2042-2052.

Leutert, Mario; Pedrioli, Deena M Leslie; Hottiger, Michael O (2016). Identification of PARP-specific ADP-ribosylation targets reveals a regulatory function for ADP-ribosylation in transcription elongation. Molecular Cell, 63(2):181-183.

Hofer, Alexandre; Marques, Elia; Kieliger, Nicole; Gatter, Sarah-Kirsten N; Jordi, Sara; Ferrari, Elena; Hofmann, Manuel; Fitzpatrick, Teresa B; Hottiger, Michael O; Jessen, Henning J (2016). Chemoselective Dimerization of Phosphates. Organic Letters, 18(13):3222-3225.

Furrer, Antonia; Hottiger, Michael O; Valaperti, Alan (2016). Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation. Molecular Immunology, 74:47-58.

Watanabe, Yukihide; Papoutsoglou, Panagiotis; Maturi, Varun; Tsubakihara, Yutaro; Hottiger, Michael O; Heldin, Carl-Henrik; Moustakas, Aristidis (2016). Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation. Journal of Biological Chemistry, 291(24):12706-12723.

Hottiger, Michael O (2016). SnapShot: ADP-Ribosylation Signaling. Molecular Cell, 62(3):472.

Kresoja-Rakic, Jelena; Kapaklikaya, Esra; Ziltener, Gabriela; Dalcher, Damian; Santoro, Raffaella; Christensen, Brock C; Johnson, Kevin C; Schwaller, Beat; Weder, Walter; Stahel, Rolf A; Felley-Bosco, Emanuela (2016). Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells. OncoTarget, 7(16):21272-21286.

Aguzzi, Adriano; Altmeyer, Matthias (2016). Phase separation: linking cellular compartmentalization to disease. Trends in Cell Biology, 26(7):547-558.

Wang, C; Qu, C; Alippe, Y; Bonar, S L; Civitelli, R; Abu-Amer, Y; Hottiger, M O; Mbalaviele, G (2016). Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation. Cell Death and Disease, 7(3):e2153.

Schuster, Sabine; Roessler, Claudia; Meleshin, Marat; Zimmermann, Philipp; Simic, Zeljko; Kambach, Christian; Schiene-Fischer, Cordelia; Steegborn, Clemens; Hottiger, Michael O; Schutkowski, Mike (2016). A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions. Scientific Reports, 6:22643.

Becker, Annette; Zhang, Peng; Allmann, Lena; Meilinger, Daniela; Bertulat, Bianca; Eck, Daniel; Hofstaetter, Maria; Bartolomei, Giody; Hottiger, Michael O; Schreiber, Valérie; Leonhardt, Heinrich; Cardoso, M Cristina (2016). Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure. Journal of Biological Chemistry, 291(10):4873-4881.

Bartolomei, Giody; Leutert, Mario; Manzo, Massimiliano; Baubec, Tuncay; Hottiger, Michael O (2016). Analysis of chromatin ADP-Ribosylation at the genome-wide level and at specific loci by ADPr-ChAP. Molecular Cell, 61(3):474-485.

Robaszkiewicz, Agnieszka; Qu, Chao; Wisnik, Ewelina; Ploszaj, Tomasz; Mirsaidi, Ali; Kunze, Friedrich A; Richards, Peter J; Cinelli, Paolo; Mbalaviele, Gabriel; Hottiger, Michael O (2016). ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β. Scientific Reports, 6:21131.

Ochs, Fena; Somyajit, Kumar; Altmeyer, Matthias; Rask, Maj-Britt; Lukas, Jiri; Lukas, Claudia (2016). 53BP1 fosters fidelity of homology-directed DNA repair. Nature Structural & Molecular Biology, 23(8):714-721.

Duda, Heike; Arter, Meret; Gloggnitzer, Jiradet; Teloni, Federico; Wild, Philipp; Blanco, Miguel G; Altmeyer, Matthias; Matos, Joao (2016). A mechanism for controlled breakage of under-replicated chromosomes during mitosis. Developmental Cell, 39(6):740-755.

Ahuja, Akshay K; Jodkowska, Karolina; Teloni, Federico; Bizard, Anna H; Zellweger, Ralph; Herrador, Raquel; Ortega, Sagrario; Hickson, Ian D; Altmeyer, Matthias; Mendez, Juan; Lopes, Massimo (2016). A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nature Communications, 7:10660-10671.

Barrow, Joeva J; Balsa, Eduardo; Verdeguer, Francisco; Tavares, Clint D J; Soustek, Meghan S; Hollingsworth, Louis R; Jedrychowski, Mark; Vogel, Rutger; Paulo, Joao A; Smeitink, Jan; Gygi, Steve P; Doench, John; Root, David E; Puigserver, Pere (2016). Bromodomain inhibitors correct bioenergetic deficiency caused by mitochondrial disease complex I mutations. Molecular Cell, 64(1):163-175.

Leone, Sergio; Santoro, Raffaella (2016). Challenges in the analysis of long noncoding RNA functionality. FEBS letters, 590(15):2342-2353.

Ma, Bin; Hottiger, Michael O (2016). Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation. Frontiers in Immunology, 7:378.

Hiragami-Hamada, Kyoko; Soeroes, Szabolcs; Nikolov, Miroslav; Wilkins, Bryan; Kreuz, Sarah; Chen, Carol; De La Rosa-Velázquez, Inti A; Zenn, Hans Michael; Kost, Nils; Pohl, Wiebke; Chernev, Aleksandar; Schwarzer, Dirk; Jenuwein, Thomas; Lorincz, Matthew; Zimmermann, Bastian; Walla, Peter Jomo; Neumann, Heinz; Baubec, Tuncay; Urlaub, Henning; Fischle, Wolfgang (2016). Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin. Nature Communications, 7:11310.

Andersson, Anneli. HMGB1 controls ARTD1 function during stress signaling. 2016, University of Zurich, Faculty of Science.

Pellegrino, Stefania; Altmeyer, Matthias (2016). Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress. Frontiers in Genetics:7:63.

Andersson, Anneli; Bluwstein, Andrej; Kumar, Nitin; Teloni, Federico; Traenkle, Jens; Baudis, Michael; Altmeyer, Matthias; Hottiger, Michael O (2016). PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation. Nucleic Acids Research, 44(16):7630-7645.

Becker, Annette; Zhang, Peng; Allmann, Lena; Meilinger, Daniela; Bertulat, Bianca; Eck, Daniel; Hofstaetter, Maria; Bartolomei, Giody; Hottiger, Michael O; Schreiber, Valérie; Leonhardt, Heinrich; Cardoso, M Cristina (2016). Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure. Journal of Biological Chemistry, 291(17):9382.

Glanz, Stephan. Role of serine protease HTRA1 in the regulation of mouse adipose-derived stromal cell osteogenesis. 2016, University of Zurich, Faculty of Science.

Rosenthal, Florian; Nanni, Paolo; Barkow-Oesterreicher, Simon; Hottiger, Michael O (2015). Optimization of LTQ-Orbitrap mass spectrometer parameters for the identification of ADP-ribosylation sites. Journal of Proteome Research, 14(9):4072-4079.

Shakhova, Olga; Cheng, Phil; Mishra, Pravin J; Zingg, Daniel; Schaefer, Simon M; Debbache, Julien; Häusel, Jessica; Matter, Claudia; Guo, Theresa; Davis, Sean; Meltzer, Paul; Mihic-Probst, Daniela; Moch, Holger; Wegner, Michael; Merlino, Glenn; Levesque, Mitchell P; Dummer, Reinhard; Santoro, Raffaella; Cinelli, Paolo; Sommer, Lukas (2015). Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma. PLoS Genetics, 11(1):e1004877.

Zingg, Daniel; Debbache, Julien; Schaefer, Simon M; Tuncer, Eylul; Frommel, Sandra C; Cheng, Phil; Arenas-Ramirez, Natalia; Haeusel, Jessica; Zhang, Yudong; Bonalli, Mario; McCabe, Michael T; Creasy, Caretha L; Levesque, Mitchell P; Boyman, Onur; Santoro, Raffaella; Shakhova, Olga; Dummer, Reinhard; Sommer, Lukas (2015). The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors. Nature Communications, 6:6051.

Gu, Lei; Frommel, Sandra C; Oakes, Christopher C; Simon, Ronald; Grupp, Katharina; Gerig, Cristina Y; Bär, Dominik; Robinson, Mark D; Baer, Constance; Weiss, Melanie; Gu, Zuguang; Schapira, Matthieu; Kuner, Ruprecht; Sültmann, Holger; Provenzano, Maurizio; Yaspo, Marie-Laure; Brors, Benedikt; Korbel, Jan; Schlomm, Thorsten; Sauter, Guido; Eils, Roland; Plass, Christoph; Santoro, Raffaella (2015). BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence. Nature Genetics, 47(1):22-30.

Lehmann, Mareike; Pirinen, Eija; Mirsaidi, Ali; Kunze, Friedrich A; Richards, Peter J; Auwerx, Johan; Hottiger, Michael O (2015). ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange. Nucleic Acids Research, 43(1):129-142.

Vollenweider, Eva. Epigenetic and chromatin inheritance of euchromatic and heterochromatic sequences. 2015, University of Zurich, Faculty of Science.

Cheng, Phil F; Shakhova, Olga; Widmer, Daniel S; Eichhoff, Ossia M; Zingg, Daniel; Frommel, Sandra C; Belloni, Benedetta; Raaijmakers, Marieke I G; Goldinger, Simone M; Santoro, Raffaella; Hemmi, Silvio; Sommer, Lukas; Dummer, Reinhard; Levesque, Mitchell P (2015). Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma. Genome Biology, 16:42.

Miranda, Melroy X; van Tits, Lambertus J; Lohmann, Christine; Arsiwala, Tasneem; Winnik, Stephan; Tailleux, Anne; Stein, Sokrates; Gomes, Ana P; Suri, Vipin; Ellis, James L; Lutz, Thomas A; Hottiger, Michael O; Sinclair, David A; Auwerx, Johan; Schoonjans, Kristina; Staels, Bart; Lüscher, Thomas F; Matter, Christian M (2015). The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. European Heart Journal, 36(1):51-59.

Savić, Nataša; Bär, Dominik; Leone, Sergio; Frommel, Sandra C; Weber, Fabienne A; Vollenweider, Eva; Ferrari, Elena; Ziegler, Urs; Kaech, Andres; Shakhova, Olga; Cinelli, Paolo; Santoro, Raffaella (2014). lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs. Cell Stem Cell, 15(6):720-734.

Ryu, Dongryeol; Jo, Young Suk; Lo Sasso, Giuseppe; Stein, Sokrates; Zhang, Hongbo; Perino, Alessia; Lee, Jung Uee; Zeviani, Massimo; Romand, Raymond; Hottiger, Michael O; Schoonjans, Kristina; Auwerx, Johan (2014). A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. Cell Metabolism, 20(5):856-869.

Larsen, Dorthe H; Hari, Flurina; Clapperton, Julie A; Gwerder, Myriam; Gutsche, Katrin; Altmeyer, Matthias; Jungmichel, Stephanie; Toledo, Luis I; Fink, Daniel; Rask, Maj-Britt; Grøfte, Merete; Lukas, Claudia; Nielsen, Michael L; Smerdon, Stephen J; Lukas, Jiri; Stucki, Manuel (2014). The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. Nature Cell Biology, 16(8):792-803.

Pirinen, Eija; Cantó, Carles; Jo, Young Suk; Morato, Laia; Zhang, Hongbo; Menzies, Keir J; Williams, Evan G; Mouchiroud, Laurent; Moullan, Norman; Hagberg, Carolina; Li, Wei; Timmers, Silvie; Imhof, Ralph; Verbeek, Jef; Pujol, Aurora; van Loon, Barbara; Viscomi, Carlo; Zeviani, Massimo; Schrauwen, Patrick; Sauve, Anthony A; Schoonjans, Kristina; Auwerx, Johan (2014). Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metabolism, 19(6):1034-1041.

Lehmann, Mareike. ARTD1 and poly-ADP-ribosylation enhance PPARγ-dependent adipogenesis in vitro and in vivo. 2014, University of Zurich, Faculty of Science.

Léger, Karolin; Bär, Dominik; Savić, Nataša; Santoro, Raffaella; Hottiger, Michael O (2014). ARTD2 activity is stimulated by RNA. Nucleic Acids Research, 42(8):5072-5082.

Santoro, Raffaella (2014). Analysis of chromatin composition of repetitive sequences: the ChIP-Chop assay. In: Santoro, Raffaella. Functional Analysis of DNA and Chromatin. University of Zurich, Switzerland: Humana Press (Springer), 319-28.

Grosse, Nicole; van Loon, Barbara; Rohrer Bley, Carla (2014). DNA damage response and DNA repair - dog as a model? BMC Cancer, 14:203.

Bachmann, Samia B; Frommel, Sandra C; Camicia, Rosalba; Winkler, Hans C; Santoro, Raffaella; Hassa, Paul O (2014). DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. Molecular Cancer, 13:125.

Dahl, Markus; Maturi, Varun; Lönn, Peter; Papoutsoglou, Panagiotis; Zieba, Agata; Vanlandewijck, Michael; van der Heide, Lars P; Watanabe, Yukihide; Söderberg, Ola; Hottiger, Michael O; Heldin, Carl-Henrik; Moustakas, Aristidis (2014). Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling. PLoS ONE, 9(8):e103651.

Bachmann, Samia Beatrice. Functional roles of DTX3L and ARTD9 in prostate cancer. 2014, University of Zurich, Vetsuisse Faculty.

Furrer, Antonia; van Loon, Barbara (2014). Handling the 3-methylcytosine lesion by six human DNA polymerases members of the B-, X- and Y-families. Nucleic Acids Research, 42(1):553-566.

Rosenthal, Florian; Hottiger, Michael O (2014). Identification of ADP-ribosylated peptides and ADP-ribose acceptor sites. Frontiers in Bioscience (Landmark Edition), 19(7):1041-1056.

Bachmann, Samia Beatrice. LinkFunctional roles of DTX3L and ARTD9 in prostate cancer. 2014, University of Zurich, Vetsuisse Faculty.

Lo Sasso, Giuseppe; Ryu, Dongryeol; Mouchiroud, Laurent; Fernando, Samodha C; Anderson, Christopher L; Katsyuba, Elena; Piersigilli, Alessandra; Hottiger, Michael O; Schoonjans, Kristina; Auwerx, Johan (2014). Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. PLoS ONE, 9(7):e102495.

Barandun, Marc André. Posttranslational modification of histone 1.4 by SET7/9 and ARTD1. 2014, University of Zurich, Vetsuisse Faculty.

Wyck, Sarah Luisa. Regulation of human DNA polymerase β by protein kinase C mediated phosphorylation. 2014, University of Zurich, Vetsuisse Faculty.

Gerig, Cristina Yasoma. Role of TIP5 in metastatic prostate cancer and osteosarcoma cells. 2014, University of Zurich, Vetsuisse Faculty.

van Loon, Barbara; Samson, Leona D (2013). Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB). DNA repair, 12(3):177-187.

Weber, Fabienne A; Bartolomei, Giody; Hottiger, Michael O; Cinelli, Paolo (2013). Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation. Stem Cells, 31(11):2364-2373.

Rosenthal, Florian. Biochemical and mass spectrometric characterization of protein ADP-ribosylation. 2013, University of Zurich, Faculty of Science.

Kassner, Ingrid; Barandun, Marc; Fey, Monika; Rosenthal, Florian; Hottiger, Michael O (2013). Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4. Epigenetics & Chromatin, 6:1.

Maga, Giovanni; Crespan, Emmanuele; Markkanen, Enni; Imhof, Ralph; Furrer, Antonia; Villani, Giuseppe; Hübscher, Ulrich; van Loon, Barbara (2013). DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass. Proceedings of the National Academy of Sciences of the United States of America, 110(47):18850-18855.

Léger, Karolin. Distinct functions of ARTD1 and ARTD2 in cell cycle entry and the genotoxic stress response. 2013, University of Zurich, Faculty of Science.

Simonelli, Valeria; Camerini, Serena; Mazzei, Filomena; Van Loon, Barbara; Allione, Alessandra; D'Errico, Mariarosaria; Barone, Flavia; Minoprio, Anna; Ricceri, Fulvio; Guarrera, Simonetta; Russo, Alessia; Dalhus, Bjørn; Crescenzi, Marco; Hübscher, Ulrich; Bjørås, Magnar; Matullo, Giuseppe; Dogliotti, Eugenia (2013). Genotype-phenotype analysis of S326C OGG1 polymorphism: a risk factor for oxidative pathologies. Free Radical Biology & Medicine, 63:401-409.

Crespan, Emmanuele; Pasi, Emanuela; Imoto, Shuhei; Hübscher, Ulrich; Greenberg, Marc M; Maga, Giovanni (2013). Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen. ACS Chemical Biology, 8(2):336-344.

Quero, Lilian; Klawitter, Marina; Schmaus, Anja; Rothley, Melanie; Sleeman, Jonathan; Tiaden, André N; Klasen, Juergen; Boos, Norbert; Hottiger, Michael O; Wuertz, Karin; Richards, Peter (2013). Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways. Arthritis Research & Therapy, 15(4):R94.

Markkanen, Enni; Dorn, Julia; Hübscher, Ulrich (2013). MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA. Frontiers in Genetics:4:18.

Rosenthal, Florian; Feijs, Karla L H; Frugier, Emilie; Bonalli, Mario; Forst, Alexandra H; Imhof, Ralph; Winkler, Hans C; Fischer, David; Caflisch, Amedeo; Hassa, Paul O; Lüscher, Bernhard; Hottiger, Michael O (2013). Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Nature Structural & Molecular Biology, 20(4):502-507.

Dianov, Grigory L; Hübscher, Ulrich (2013). Mammalian base excision repair: the forgotten archangel. Nucleic Acids Research, 41(6):3483-3490.

Lindgren, Anders E G; Karlberg, Tobias; Thorsell, Ann-Gerd; Hesse, Mareike; Spjut, Sara; Ekblad, Torun; Andersson, C David; Pinto, Ana Filipa; Weigelt, Johan; Hottiger, Michael O; Linusson, Anna; Elofsson, Mikael; Schüler, Herwig (2013). PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chemical Biology, 8(8):1698-1703.

Kraus, W Lee; Hottiger, Michael O (2013). PARP-1 and gene regulation: progress and puzzles. Molecular Aspects of Medicine, 34(6):1109-1123.

Bluwstein, A; Kumar, N; Léger, K; Traenkle, J; van Oostrum, J; Rehrauer, H; Baudis, Michael; Hottiger, M O (2013). PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts. Cell Death and Disease, 4:e498.

Jungmichel, Stephanie; Rosenthal, Florian; Altmeyer, Matthias; Lukas, Jiri; Hottiger, Michael O; Nielsen, Michael L (2013). Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. Molecular Cell, 52(2):272-285.

Kassner, Ingrid; Andersson, Anneli; Fey, Monika; Tomas, Martin; Ferrando-May, Elisa; Hottiger, Michael O (2013). SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress. Open Biology, 3(10):120173.

Zucca, Elisa; Bertoletti, Federica; Wimmer, Ursula; Ferrari, Elena; Mazzini, Giuliano; Khoronenkova, Svetlana; Grosse, Nicole; van Loon, Barbara; Dianov, Grigory; Hübscher, Ulrich; Maga, Giovanni (2013). Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint. Nucleic Acids Research, 41(1):229-241.

Bluwstein, Andrej. Systemic analysis of the radiation and oxidation induced cellular signaling response. 2013, University of Zurich, Faculty of Science.

Ziesché, Elisabeth; Kettner-Buhrow, Daniela; Weber, Axel; Wittwer, Tobias; Jurida, Liane; Soelch, Johanna; Müller, Helmut; Newel, Doris; Kronich, Petra; Schneider, Heike; Dittrich-Breiholz, Oliver; Bhaskara, Srividya; Hiebert, Scott W; Hottiger, Michael O; Li, Haiying; Burstein, Ezra; Schmitz, M Lienhard; Kracht, Michael (2013). The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. Nucleic Acids Research, 41(1):90-109.

Dantzer, Françoise; Santoro, Raffaella (2013). The expanding role of PARPs in the establishment and maintenance of heterochromatin. FEBS Journal, 280(15):3508-3018.

Aria, Valentina; De Felice, Mariarita; Di Perna, Roberta; Uno, Shuji; Masai, Hisao; Syväoja, Juhani E; van Loon, Barbara; Hübscher, Ulrich; Pisani, Francesca M (2013). The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity. Journal of Biological Chemistry, 288(18):12742-12752.

Eisele, Petra S; Salatino, Silvia; Sobek, Jens; Hottiger, Michael O; Handschin, Christoph (2013). The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. Journal of Biological Chemistry, 288(4):2246-2260.

Guetg, Claudio. Role of non-coding RNA in epigenetic inheritance of ribosomal RNA gene silencing. 2012, University of Zurich, Faculty of Science.

Raffaella, Santoro. Evolutionary diversity and developmental regulation of gene dosage compensation i XX female and XY male animals. 2012, University of Zurich, Vetsuisse Faculty.

Crespan, Emmanuele; Maga, Giovanni; Hübscher, Ulrich (2012). A new proofreading mechanism for lesion bypass by DNA polymerase-λ. EMBO Reports, 13(1):68-74.

Markkanen, Enni Emilia; Castrec, Benoit; Villani, Giuseppe; Hübscher, Ulrich (2012). A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesions. Proceedings of the National Academy of Sciences of the United States of America, 109(50):20401-20406.

Erener, Süheda; Mirsaidi, Ali; Hesse, Mareike; Tiaden, André N; Ellingsgaard, Helga; Kostadinova, Radina; Donath, Marc Y; Richards, Peter J; Hottiger, Michael O (2012). ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation. FASEB Journal, 26(6):2631-2638.

Bosshard, Matthias; Markkanen, Enni; van Loon, Barbara (2012). Base excision repair in physiology and pathology of the central nervous system. International Journal of Molecular Sciences, 13(12):16172-16222.

Guetg, Claudio; Santoro, Raffaella (2012). Formation of nuclear heterochromatin: the nucleolar point of view. Epigenetics, 7(8):811-814.

Winkler, Hans Christian. Identification of p62 as interaction partner of ARTD9: is ARTD9 degraded by autophagy? 2012, University of Zurich, Vetsuisse Faculty.

Erener, Süheda; Pétrilli, Virginie; Kassner, Ingrid; Minotti, Roberta; Castillo, Rosa; Santoro, Raffaella; Hassa, Paul O; Tschopp, Jürg; Hottiger, Michael O (2012). Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes. Molecular Cell, 46(2):200-211.

Guetg, Claudio; Scheifele, Fabian; Rosenthal, Florian; Hottiger, Michael O; Santoro, Raffaella (2012). Inheritance of silent rDNA chromatin is mediated by PARP1 via noncoding RNA. Molecular Cell, 45(6):790-800.

Kanagaraj, Radhakrishnan; Parasuraman, Prasanna; Mihaljevic, Boris; van Loon, Barbara; Burdova, Kamila; König, Christiane; Furrer, Antonia; Bohr, Vilhelm A; Hübscher, Ulrich; Janscak, Pavel (2012). Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage. Nucleic Acids Research, 40(17):8449-8459.

Crespan, Emmanuele; Czabany, Tibor; Maga, Giovanni; Hübscher, Ulrich (2012). Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences. Nucleic Acids Research, 40(12):5577-5590.

Guetg, Claudio; Santoro, Raffaella (2012). Noncoding RNAs link PARP1 to heterochromatin. Cell Cycle, 11(12):2217-2218.

Razumenko, Mykhailo. Oxygen-dependent regulation of base excision repair and its role in oxidative stress tolerance and tumor therapy resistance. 2012, University of Zurich, Faculty of Science.

Erener, Süheda; Hesse, Mareike; Kostadinova, Radina; Hottiger, Michael O (2012). Poly(ADP-ribose)polymerase-1 (PARP1) controls adipogenic gene expression and adipocyte function. Molecular Endocrinology, 26(1):79-86.

Kassner, Ingrid. Regulation of ARTD1 by SET7/9-dependent methylation. 2012, University of Zurich, Faculty of Science.

Markkanen, E; van Loon, B; Ferrari, E; Parsons, J L; Dianov, G L; Hübscher, U (2012). Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 109(2):437-442.

Markkanen, Enni; Hübscher, Ulrich; van Loon, Barbara (2012). Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem. Cell Cycle, 11(6):1070-1075.

Rast, Tanja. Tandem purification of Mre11/Rad50-dimers using the baculovirus expression system. 2012, University of Zurich, Vetsuisse Faculty.

Ali, Ammar A E; Timinszky, Gyula; Arribas-Bosacoma, Raquel; Kozlowski, Marek; Hassa, Paul O; Hassler, Markus; Ladurner, Andreas G; Pearl, Laurence H; Oliver, Antony W (2012). The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Nature Structural & Molecular Biology, 19(7):685-692.

Markkanen, Enni Emilia. Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of posttranslational modifications. 2011, University of Zurich, Faculty of Science.

Hottiger, M O (2011). ADP-ribosylation of histones by ARTD1: an additional module of the histone code? FEBS Letters, 585(11):1595-1599.

Hübscher, U; Maga, G (2011). DNA replication and repair bypass machines. Current Opinion in Chemical Biology, 15(5):627-635.

Eger, S; Castrec, B; Hübscher, U; Scheffner, M; Rubini, M; Marx, A (2011). Generation of a mono-ubiquitinated PCNA mimic by click chemistry. ChemBioChem, 12(18):2807-2812.

Chen, Y; Wang, H; Yoon, S O; Xu, X; Hottiger, M O; Svaren, J; Nave, K A; Kim, H A; Olson, E N; Lu, Q R (2011). HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination. Nature Neuroscience, 14(4):437-441.

Messner, S; Hottiger, M O (2011). Histone ADP-ribosylation in DNA repair, replication and transcription. Trends in Cell Biology, 21(9):534-542.

Villani, G; Hübscher, U; Gironis, N; Parkkinen, S; Pospiech, H; Shevelev, I; di Cicco, G; Markkanen, E; Syväoja, J E; Tanguy Le Gac, N (2011). In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta. Journal of Biological Chemistry, 286(37):32094-32104.

Robert-Tissot, Céline. Induction of resistance to viral infections in the domestic cat by stimulation of the immune system. 2011, University of Zurich, Faculty of Science.

Hottiger, M O (2011). Mehr als nur synthetische Lethalität mit BRCA1/2. Vet-MedReport, 38(V4):4.

Valovka, T; Hottiger, M O (2011). P65 controls NF-κB activity by regulating cellular localization of IκBβ. Biochemical Journal, 434(2):253-263.

Gebhard, C; Stähli, B E; Shi, Y; Camici, G G; Akhmedov, A; Hoegger, L; Lohmann, C; Matter, C M; Hassa, P O; Hottiger, M O; Malinski, T; Lüscher, T F; Tanner, F C (2011). Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction. Biochemical and Biophysical Research Communications (BBRC), 414(4):641-646.

Hottiger, M O; Boothby, M; Koch-Nolte, F; Lüscher, B; Martin, N M B; Plummer, R; Wang, Z Q; Ziegler, M (2011). Progress in the function and regulation of ADP-Ribosylation. Science Signaling, 4(174):mr5.

Santoro, R (2011). The epigenetics of the nucleolus: structure and function of active and silent ribosomal RNA genes. In: Olson, M O J. The Nucleolus. New York [etc.]: Springer, 57-82.

Markkanen, E; van Loon, B; Ferrari, E; Hübscher, U (2011). Ubiquitylation of DNA polymerase λ. FEBS Letters, 585(18):2826-2830.

Notz, C. Zur Wirksamkeit einer komplementärmedizinischen (homöopathischen) Mastitisprophylaxe zum Trockenstellen und zum Abkalben beim Rind. 2011, University of Zurich, Vetsuisse Faculty.

Santoro, R; Schmitz, K M; Sandoval, J; Grummt, I (2010). Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans. EMBO Reports, (11):52-58.

Asher, G; Reinke, H; Altmeyer, M; Gutierrez-Arcelus, M; Hottiger, M O; Schibler, U (2010). Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell, 142(6):943-953.

Altmeyer, M; Barthel, M; Eberhard, M; Rehrauer, H; Hardt, W D; Hottiger, M O (2010). Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation. Infection and Immunity, 78(8):3420-3431.

Toller, I M; Altmeyer, M; Kohler, E; Hottiger, M O; Müller, Anne (2010). Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia. Cancer Research, 70(14):5912-5922.

Messner, S; Altmeyer, M; Zhao, H; Pozivil, A; Roschitzki, B; Gehrig, P; Rutishauser, D; Huang, D; Caflisch, A; Hottiger, M O (2010). PARP1 ADP-ribosylates lysine residues of the core histone tails. Nucleic Acids Research, 38(19):6350-6362.

Hari, F J; Spycher, Christoph; Jungmichel, S; Pavic, L; Stucki, M (2010). A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin. EMBO Reports, 11(5):387-392.

Püntener, Daniel. A live cell reporter of human adenovirus chromatin. 2010, University of Zurich, Faculty of Science.

Rothgiesser, K M; Fey, M; Hottiger, M O (2010). Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression. BMC Genomics, 11:22.

Parasuraman, Prasanna. Artificially engineered and WRN protein bridged DNA polymerase lambda leads to improved translesion synthesis. 2010, University of Zurich, Faculty of Science.

DNA Polymerases Discovery,Characterizations and Functions in Cellular DNA Transactions. Edited by: Hübscher, U; Spadari, S; Villani, G; Maga, G (2010). Singapure, Singapure: World Scientific Publishing Co. PTE. Ltd..

Locatelli, G A; Pospiech, H; Tanguy Le Gac, N; van Loon, B; Hubscher, U; Parkkinen, S; Syväoja, J E; Villani, G (2010). Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase in the presence of replication protein A and proliferating-cell nuclear antigen. Biochemical Journal, 429(3):573-582.

van Loon, Barbara. Faithful DNA repair of 7,8-dihydro-8-oxo-guanine lesions by human enzymes. 2010, University of Zurich, Faculty of Science.

Furter, L M. Geopathische Störzonen und ihre Auswirkungen auf die Gesundheit von Milchkühen. 2010, University of Zurich, Vetsuisse Faculty.

Pozivil, A U. Identification of lysine residues as ADP-ribose acceptor sites in core histone tails. 2010, University of Zurich, Vetsuisse Faculty.

Bosshard, Matthias Lukas. Involvement of the AAA ATPase p97/VCP in DNA metabolism. 2010, University of Zurich, Vetsuisse Faculty.

Jungmichel, S; Stucki, M (2010). MDC1: The art of keeping things in focus. Chromosoma, 119(4):337-349.

Morf, Laura. Machineries for change: differentiation in the minimized eukaryote Giardia lamblia. 2010, University of Zurich, Faculty of Science.

Jungmichel, Stephanie. Mechanism of DNA damage-induced MDC1 dimerization. 2010, University of Zurich, Faculty of Science.

Altmeyer, Matthias. Mechanism of poly(ADP-ribose) formation and the role of PARP1 in inflammation. 2010, University of Zurich, Faculty of Science.

Günther, Viola. Molecular mechanisms of heavy metal homeostasis in flies and humans. 2010, University of Zurich, Faculty of Science.

Toller, Isabella Marietta. Molecular mechanisms of inflammation-induced cancer: T-cells as targets for prevention and cure of Heliobacter-related gastric preneoplasia. 2010, University of Zurich, Faculty of Science.

Osorio, F G; Varela, I; Lara, E; Puente, X S; Espada, J; Santoro, R; Freije, J M P; Fraga, M F; López-Otín, C (2010). Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease. Aging Cell, 9(6):947-957.

van Loon, B; Markkanen, E; Hübscher, U (2010). Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine. DNA Repair, 9(6):604-616.

Erener, Süheda. Regulation of inflammation and glucose homeostasis by poly(ADP-ribose) polymerase 1 (PARP1). 2010, University of Zurich, Faculty of Science.

Messner, Simon. Regulation of poly(ADP-ribose) polymerase 1 by sumoylation and investigation of histone poly(ADP-ribosyl)ation. 2010, University of Zurich, Faculty of Science.

Rothgiesser, K M; Erener, S; Waibel, S; Lüscher, B; Hottiger, M O (2010). SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310. Journal of Cell Science, 123(Pt 24):4251-4258.

Guetg, C; Lienemann, P; Sirri, V; Grummt, I; Hernandez-Verdun, D; Hottiger, M O; Fussenegger, M; Santoro, R (2010). The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. The EMBO Journal, 29(13):2135-2146.

Larsen, D H; Poinsignon, C; Gudjonsson, T; Dinant, C; Payne, M R; Hari, F J; Danielsen, J M R; Menard, P; Sand, J C; Stucki, M; Lukas, C; Bartek, J; Andersen, J S; Lukas, J (2010). The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. Journal of Cell Biology, 190(5):731-740.

Hottiger, M O; Hassa, P O; Lüscher, B; Schüler, H; Koch-Nolte, F (2010). Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends in Biochemical Sciences, 35(4):208-219.

Poveda, L; Hottiger, M; Boos, N; Wuertz, K (2009). Peroxynitrite induces gene expression in intervertebral disc cells. Spine, 34(11):1127-1133.

Dietschy, T; Shevelev, I; Pena-Diaz, J; Hühn, D; Kuenzle, S; Mak, R; Miah, M F; Hess, D; Fey, M; Hottiger, M O; Janscak, Pavel; Stagljar, I (2009). p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization. Journal of Cell Science, 122(Pt. 8):1258-1267.

Chapman, S W K; Metzger, N; Grest, Paula; Feige, Karsten; von Rechenberg, Brigitte; Auer, Jörg A; Hottiger, Michael O (2009). Isolation, establishment, and characterization of ex vivo equine melanoma cell cultures. In Vitro Cellular & Developmental Biology - Animal, 45(3-4):152-162.

Hübscher, U (2009). DNA Replication Fork Proteins. In: Vengrova, S; Dalgaard, J Z. DNA Replication Methods and Protocols. Totowa, NJ , USA: Humana Press.

Timinszky, G; Till, S; Hassa, P O; Hothorn, M; Kustatscher, G; Nijmeijer, B; Colombelli, J; Altmeyer, M; Stelzer, E H K; Scheffzek, K; Hottiger, M O; Ladurner, A G (2009). A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nature Structural and Molecular Biology, 16(9):923-929.

van Loon, B; Hübscher, U (2009). An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(43):18201-18206.

Jayne, S; Rothgiesser, K M; Hottiger, M O (2009). CARM1 but not its enzymatic activity is required for transcriptional coactivation of NF-kappaB-dependent gene expression. Journal of Molecular Biology, 394(3):485-495.

Hothorn, M; Neumann, H; Lenherr, E D; Wehner, M; Rybin, V; Hassa, P O; Uttenweiler, A; Reinhardt, M; Schmidt, A; Seiler, J; Ladurner, A G; Herrmann, C; Scheffzek, K; Mayer, A (2009). Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science, 324(5926):513-516.

Buob, Rebecca. DNA repair mechanism in the radioresistant bacterium Deinococcus radiodurans and in human. 2009, University of Zurich, Faculty of Science.

Schwendener, Sybille. Functional characterization of the human RECQ5 protein. 2009, University of Zurich, Faculty of Science.

Stucki, M (2009). Histone H2A.X Tyr142 phosphorylation: a novel sWItCH for apoptosis? DNA Repair, 8(7):873-876.

Spycher, Christoph. Identification and functional characterization of novel phosphorylation sites in MDC1. 2009, University of Zurich, Faculty of Science.

Clemenz, C. Interface between science and art: can art predict functions of enzymes? 2009, University of Zurich, Vetsuisse Faculty.

Bonalli, Mario-Emanuel. Investigation on phosphospecitic interactions in the DNA damage response. 2009, University of Zurich, Vetsuisse Faculty.

Bonalli, Mario-Emanuel. Investigations on phosphospecific interactions in the DNA damage response. 2009, University of Zurich, Vetsuisse Faculty.

Bäckert, S. Involvement of PARP1 in NF-kB-dependent gene expression during the cell cycle. 2009, University of Zurich, Vetsuisse Faculty.

van Loon, B; Ferrari, E; Hübscher, U (2009). Isolation of recombinant DNA elongation proteins. Methods in Molecular Biology, 521:345-359.

Altmeyer, M; Messner, S; Hassa, P O; Fey, M; Hottiger, M O (2009). Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Research, 37(11):3723-3738.

Hermann, Andreas. Neurotrophic effects of amylin during development of brainstem projections involved in energy homeostasis. 2009, University of Zurich, Vetsuisse Faculty.

Altmeyer, M; Hottiger, Michael O (2009). Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging, 1(5):458-469.

Rothgiesser, Karin M. Role of p65 acetylation on NF-κB-dependent gene expression. 2009, University of Zurich, Faculty of Science.

Rajamohan, S B; Pillai, V B; Gupta, M; Sundaresan, N R; Birukov, K G; Samant, S; Hottiger, M O; Gupta, M P (2009). SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Molecular and Cellular Biology, 29(15):4116-4129.

Messner, S; Schuermann, D; Altmeyer, M; Kassner, I; Schmidt, D; Schär, P; Müller, S; Hottiger, M O (2009). Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function. FASEB Journal, 23(11):3978-3989.

Maga, G; van Loon, B; Crespan, E; Villani, G; Hübscher, U (2009). The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1. Journal of Biological Chemistry, 284(21):14267-1475.

Stucki, M. The discovery of MDC1 and its role in the DNA damage response. 2009, University of Zurich, Vetsuisse Faculty.

Hassa, Paul O (2009). The molecular "Jekyll and Hyde" duality of PARP1 in cell death and cell survival. Frontiers in Bioscience (Landmark Edition), 14:72-111.

Haenni, S S; Altmeyer, M; Hassa, P O; Valovka, T; Fey, M; Hottiger, M O (2008). Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS. BMC Cell Biology, 9:39.

Amoroso, A; Crespan, E; Wimmer, U; Hubscher, U; Maga, G (2008). DNA Polymerases and Oxidative Damage: Friends or Foes? Current Molecular Pharmacology, 1(2):162-170.

Maga, G; Hübscher, U (2008). Repair and Translesion DNA Polymerases as Anticancer Drug Targets. Anti-Cancer Agents in Medicinal Chemistry, 8(4):431-447.

Kamau Chapman, S W; Hassa, P O; Koch-Schneidemann, S; von Rechenberg, Brigitte; Hofmann-Amtenbrink, M; Steitz, B; Petri-Fink, A; Hofmann, H; Hottiger, Michael O (2008). Application of pulsed magnetic field enhances non-viral gene delivery in primary cells from different origins. Journal of Magnetism and Magnetic Materials, 320(8):1517-1527.

Hassa, P O; Covic, M; Bedford, M T; Hottiger, M O (2008). Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. Journal of Molecular Biology, 377(3):668-678.

Buerki, C; Rothgiesser, K M; Valovka, T; Owen, H R; Rehrauer, H; Fey, M; Lane, W S; Hottiger, M O (2008). Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Research, 36(5):1665-1680.

Belousova, E A; Crespan, E; Lebedeva, N A; Rechunova, N J; Hübscher, U; Maga, G; Lavrik, O I (2008). Photoreactive DNA Probes as a Tool for Studying the Translesion Synthesis System in Mammalian Cell Extracts. Medicinal Chemistry, 4(2):155-162.

Elser, M; Borsig, L; Hassa, P O; Erener, S; Messner, S; Valovka, T; Keller, S; Gassmann, M; Hottiger, M O (2008). Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression. Molecular Cancer Research, 6(2):282-290.

Hassa, Paul O; Hottiger, Michael O (2008). The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Frontiers in Bioscience (Landmark Edition), 13:3046-3082.

Radhakrishnan, Kanagaraj. Biochemistry of Human RecQ DNA Helicases and their Role in DNA Repair. 2008, University of Zurich, Faculty of Science.

Spycher, C; Miller, E S; Townsend, K; Pavic, L; Morrice, N A; Janscak, Pavel; Stewart, G S; Stucki, M (2008). Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. Journal of Cell Biology, 181(2):227-240.

Wimmer, U; Ferrari, E; Hunziker, P; Hübscher, U (2008). Control of DNA polymerase lambda stability by phosphorylation and ubiquitination during the cell cycle. EMBO Reports, 9(10):1027-1033.

Blasius, M; Sommer, S; Hubscher, U (2008). Deinococcus radiodurans: What Belongs to the Survival Kit? Critical Reviews in Biochemistry and Molecular Biology, 43(3):221-238.

Haenni, S S; Hassa, P O; Altmeyer, M; Fey, M; Imhof, R; Hottiger, M O (2008). Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation. International Journal of Biochemistry & Cell Biology, 40(10):2274-2283.

Hübscher, Ulrich (2008). Obituary; Arthur Kornberg (1918-2007). Angewandte Chemie Internationale Edition, 47(7):1172.

von Lukowicz, T; Hassa, P O; Lohmann, C; Borén, J; Braunersreuther, V; Mach, F; Odermatt, B; Gersbach, M; Camici, G G; Stähli, B E; Tanner, F C; Hottiger, Michael O; Lüscher, T F; Matter, C M (2008). PARP1 is required for adhesion molecule expression in atherogenesis. Cardiovascular Research, 78(1):158-166.

Poveda, Lucy. Pathophysiological pro-inflammatory and pain-inducing mechanisms in degenerative intervertebral discs. 2008, University of Zurich, Faculty of Science.

Hänni, S. Regulation of PARP-1 and PARP-2 by lysine acetylation. 2008, University of Zurich, Faculty of Science.

Crespan, M; Cancio, E; Spadari, S; Hübscher, U; Maga, G (2008). Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the “primer grip” region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. Biochemical Pharmacology, 76(2):156-168.

Kleine, H; Poreba, E; Lesniewicz, K; Hassa, P O; Hottiger, M O; Litchfield, D W; Shilton, B H; Lüscher, B (2008). Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. Molecular Cell, 32(1):57-69.

Selak, N; Bachrati, C Z; Shevelev, I; Dietschy, T; van Loon, B; Jacob, A; Hübscher, U; Hoheisel, J D; Hickson, I D; Stagljar, I (2008). The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta. Nucleic Acids Research, 36(16):5166-5179.

Gembka, A; Smirnova, E; Hübscher, U (2008). The checkpoint sensors, the 9-1-1 complex and the Rad17-RF-C2-5 complex: at the crossroads of DNA damage checkpoint and DNA repair. In: Maga, G; Hübscher, U; Villani, G; Baldacci, G. DNA Replication, Repair and Recombination at the Crossroad Between Genome Integrity and Genomic Instability : A Biochemical Perspective. Kerala: Research Signpost, 77-86.

Blasius, M; Buob, R; Shevelev, I V; Hubscher, U (2007). Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radiodurans. BMC Molecular Biology, 8:69.

Crespan, E; Hübscher, U; Maga, G (2007). Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. Nucleic Acids Research, 35(15):5173-5181.

Maga, G; Amacker, M; Hübscher, U; Gosselin, G; Imbach, J L; Mathé, C; Faraj, A; Sommadossi, J P; Spadari, S (2006). Structural determinants of HIV-1 reverse transcriptase stereoselectivity towards (beta)-L-deoxy- and dideoxy-pyrimidine nucleoside triphosphates: molecular basis for the combination of L-dideoxynucleoside analogs with non-nucleoside inhibitors in anti HIV chemotherapy. Nucleosides, Nucleotides and Nucleic Acids, 18(4-5):795-805.

El-Andaloussi, N; Valovka, T; Toueille, M; Steinacher, R; Focke, F; Gehrig, P; Covic, M; Hassa, P O; Schär, P; Hübscher, U; Hottiger, M O (2006). Arginine methylation regulates DNA polymerase beta. Molecular Cell, 22(1):51-62.

Blasius, Melanie; Shevelev, Igor; Jolivet, Edmond; Sommer, Suzanne; Hübscher, Ulrich (2006). DNA polymerase X from Deinococcus radiodurans possesses a structure-modulated 3'-->5' exonuclease activity involved in radioresistance. Molecular Microbiology, 60(1):165-176.

Maga, G; Shevelev, I; Villani, G; Spadari, S; Hübscher, U (2006). Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. Nucleic Acids Research, 34(5):1405-1415.

Hassa, P O; et al (2005). Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. Journal of Biological Chemistry, 280(49):40450-40464.

Sharma, S; Sommers, J A; Gary, R K; Friedrich-Heineken, E; Hübscher, U; Brosh, R M (2005). The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Research, 33(21):6769-6781.

Friedrich-Heineken, E; Toueille, M; Tännler, B; Bürki, C; Ferrari, E; Hottiger, M O; Hübscher, U (2005). The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity. Journal of Molecular Biology, 353(5):980-989.

Cancio, R; Silvestri, R; Ragno, R; Artico, M; De Martino, G; La Regina, G; Crespan, E; Zanoli, S; Hübscher, U; Spadari, S; Maga, G (2005). High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme. Antimicrobial Agents and Chemotherapy, 49(11):4546-4554.

Frouin, I; Toueille, M; Ferrari, E; Shevelev, I; Hübscher, U (2005). Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen. Nucleic Acids Research, 33(16):5354-5361.

Cramer, Mirjam; Nagy, Ivana; Murphy, Brian J; Gassmann, Max; Hottiger, Michael O; Georgiev, Oleg; Schaffner, Walter (2005). NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biological Chemistry, 386(9):865-872.

Locatelli, G A; Di Santo, R; Crespan, E; Costi, R; Roux, A; Hübscher, U; Shevelev, I; Blanca, G; Villani, G; Spadari, S; Maga, G (2005). Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells. Molecular Pharmacology, 68(2):538-550.

Crespan, E; Zanoli, S; Khandazhinskaya, A; Shevelev, I; Jasko, M; Alexandrova, L; Kukhanova, M; Blanca, G; Villani, G; Hübscher, U; Spadari, S; Maga, G (2005). Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda. Nucleic Acids Research, 33(13):4117-4127.

Locatelli, G A; Savio, M; Forti, L; Shevelev, I; Ramadan, K; Stivala, L A; Vannini, V; Hübscher, U; Spadari, S; Maga, G (2005). Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants. Biochemical Journal, 389(2):259-268.

Smirnova, E; Toueille, M; Markkanen, E; Hübscher, U (2005). The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery. Biochemical Journal, 389(1):13-17.

Henneke, G; Flament, D; Hübscher, U; Querellou, J; Raffin, J P (2005). The hyperthermophilic euryarchaeota Pyrococcus abyssi likely requires the two DNA polymerases D and B for DNA replication. Journal of Molecular Biology, 350(1):53-64.

Boudsocq, F; Benaim, P; Canitrot, Y; Knibiehler, M; Ausseil, F; Capp, J P; Bieth, A; Long, C; David, B; Shevelev, I; Frierich-Heinecken, E; Hübscher, U; Amalric, F; Massiot, G; Hoffmann, J S; Cazaux, C (2005). Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta. Molecular Pharmacology, 67(5):1485-1492.

Svetlova, M; Solovjeva, L; Blasius, M; Shevelev, I; Hubscher, U; Hanawalt, P; Tomilin, N (2005). Differential incorporation of halogenated deoxyuridines during UV-induced DNA repair synthesis in human cells. DNA Repair, 4(3):359-366.

Maga, G; Ramadan, K; Locatelli, G A; Shevelev, I; Spadari, S; Hübscher, U (2005). DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. Journal of Biological Chemistry, 280(3):1971-1981.

Crespan, E; Locatelli, G A; Cancio, R; Hübscher, U; Spadari, S; Maga, G (2005). Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz. Antimicrobial Agents and Chemotherapy, 49(1):342-349.

Ramadan, K; Shevelev, I; Hübscher, U (2004). The DNA-polymerase-X family: controllers of DNA quality? Nature Reviews. Molecular Cell Biology, 5(12):43.

Maga, G; Blanca, G; Shevelev, I; Frouin, I; Ramadan, K; Spadari, S; Villani, G; Hübscher, U (2004). The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. FASEB Journal, 18(14):1743-1745.

Blanca, G; Villani, G; Shevelev, I; Ramadan, K; Spadari, S; Hübscher, U; Maga, G (2004). Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Biochemistry, 43(36):11605-11615.

Lecointe, F; Shevelev, I V; Bailone, A; Sommer, Suzanne; Hübscher, U (2004). Involvement of an X family DNA polymerase in double-stranded break repair in the radioresistant organism Deinococcus radiodurans. Molecular Microbiology, 53(6):1721-1730.

Toueille, M; Hübscher, U (2004). Regulation of the DNA replication fork: a way to fight genomic instability. Chromosoma, 113(3):113-125.

Toueille, M; El-Andaloussi, N; Frouin, I; Freire, R; Funk, D; Shevelev, I; Friedrich-Heineken, E; Villani, G; Hottiger, Michael O; Hübscher, U (2004). The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair. Nucleic Acids Research, 32(11):3316-3324.

Ramadan, K; Shevelev, I V; Maga, G; Hübscher, U (2004). De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase. Journal of Molecular Biology, 339(2):395-404.

Locatelli, G A; Campiani, Giuseppe; Cancio, R; Morelli, E; Ramunno, A; Gemma, S; Hübscher, U; Spadari, S; Maga, G (2004). Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex. Antimicrobial Agents and Chemotherapy, 48(5):1570-1580.

Friedrich-Heineken, E; Hübscher, U (2004). The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity. Nucleic Acids Research, 32(8):2520-2528.

Shevelev, I; Blanca, G; Villani, G; Ramadan, K; Spadari, S; Hübscher, U; Maga, G (2003). Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities. Nucleic Acids Research, 31(23):6916-6925.

Bergoglio, V; Ferrari, E; Hübscher, U; Cazaux, C; Hoffmann, J S (2003). DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA. Journal of Molecular Biology, 331(5):1017-1023.

Maga, G; Hubscher, U (2003). Proliferating cell nuclear antigen (PCNA): a dancer with many partners. Journal of Cell Science, 116(15):3051-3060.

Henneke, G; Koundrioukoff, S; Hübscher, U (2003). Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Oncogene, 22(28):4301-4313.

Baldanti, Fausto; Paolucci, Stefania; Maga, Giovanni; Labo, Nazzarena; Hübscher, Ulrich; Skoblov, Alexander Yu; Victorova, Lyubov; Spadari, Silvio; Minoli, Lorenzo; Gerna, Giuseppe (2003). Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine. AIDS, 17(10):1568-1570.

Henneke, G; Friedrich-Heineken, E; Hübscher, U (2003). Flap endonuclease 1: a novel tumour suppresser protein. Trends in Biochemical Sciences, 28(7):384-390.

Blanca, G; Shevelev, I; Ramadan, K; Villani, G; Spadari, S; Hübscher, U; Maga, G (2003). Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study. Biochemistry, 42(24):7467-7476.

Tasara, T; Angerer, B; Damond, M; Winter, H; Dörhöfer, S; Hübscher, U; Amacker, M (2003). Incorporation of reporter molecule-labeled nucleotides by DNA polymerases. II. High-density labeling of natural DNA. Nucleic Acids Research, 31(10):2636-2646.

Blanca, G; Baldanti, F; Paolucci, S; Skoblov, A Y; Victorova, L; Hübscher, U; Gerna, G; Spadari, S; Maga, G (2003). Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity. Journal of Biological Chemistry, 278(18):15469-15472.

Ramadan, K; Maga, G; Shevelev, I V; Villani, G; Blanco, L; Hübscher, U (2003). Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions. Journal of Molecular Biology, 328(1):63-72.

Friedrich-Heineken, E; Henneke, G; Ferrari, E; Hübscher, U (2003). The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities. Journal of Molecular Biology, 328(1):73-84.

Henneke, G; Koundrioukoff, S; Hübscher, U (2003). Multiple roles for kinases in DNA replication. EMBO Reports, 4(3):252-256.

Maga, G; Villani, G; Ramadan, K; Shevelev, I; Tanguy Le Gac, N; Blanco, L; Blanca, G; Spadari, S; Hübscher, U (2002). Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. Journal of Biological Chemistry, 277(50):48434-48440.

Henneke, G; Gueguen, Y; Flament, D; Azam, P; Querellou, J; Dietrich, J; Hübscher, U; Raffin, J P (2002). Replication factor C from the hyperthermophilic archaeon Pyrococcus abyssi does not need ATP hydrolysis for clamp-loading and contains a functionally conserved RFC PCNA-binding domain. Journal of Molecular Biology, 323(5):795-810.

Storici, F; Henneke, G; Ferrari, E; Gordenin, D A; Hübscher, U; Resnick, M A (2002). The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair. The EMBO Journal, 21(21):5930-5942.

Dahm, K; Hübscher, U (2002). Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block. Oncogene, 21(50):7710-7719.

Maga, G; Shevelev, I; Ramadan, K; Spadari, S; Hübscher, U (2002). DNA polymerase theta purified from human cells is a high-fidelity enzyme. Journal of Molecular Biology, 319(2):359-369.

Ramadan, K; Shevelev, I V; Maga, G; Hübscher, U (2002). DNA polymerase lambda from calf thymus preferentially replicates damaged DNA. Journal of Biological Chemistry, 277(21):18454-18458.

Frouin, I; Montecucco, A; Biamonti, G; Hübscher, U; Spadari, S; Maga, G (2002). Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. The EMBO Journal, 21(10):2485-2495.

Pascucci, B; Maga, G; Hübscher, U; Bjoras, M; Seeberg, E; Hickson, I D; Villani, G; Giordano, C; Cellai, L; Dogliotti, E (2002). Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins. Nucleic Acids Research, 30(10):2124-2130.

Shevelev, I V; Hübscher, U (2002). The 3' 5' exonucleases. Nature Reviews. Molecular Cell Biology, 3(5):364-376.

Hubscher, U; Maga, G; Spadari, S (2002). Eukaryotic DNA polymerases. Annual Review of Biochemistry, 71:133-163.

Ducoux, M; Urbach, S; Baldacci, G; Hübscher, U; Koundrioukoff, S; Christensen, J; Hughes, P (2001). Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. Journal of Biological Chemistry, 276(52):49258-49266.

Maga, G; Villani, G; Tillement, V; Stucki, M; Locatelli, G A; Frouin, I; Spadari, S; Hübscher, U (2001). Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 98(25):14298-14303.

Maga, G; Ramunno, A; Nacci, V; Locatelli, G A; Spadari, S; Fiorini, I; Baldanti, F; Paolucci, S; Zavattoni, M; Bergamini, A; Galletti, B; Muck, S; Hubscher, U; Giorgi, G; Guiso, G; Caccia, S; Campiani, G (2001). The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors. Journal of Biological Chemistry, 276(48):44653-44662.

Ziemienowicz, A; Konieczny, I; Hübscher, U (2001). Calf thymus Hsc70 and Hsc40 can substitute for DnaK and DnaJ function in protein renaturation but not in bacteriophage DNA replication. FEBS Letters, 507(1):11-15.

Tasara, T; Maga, G; Hottiger, M O; Hübscher, U (2001). HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other. FEBS Letters, 507(1):39-44.

Miller, J T; Ehresmann, B; Hübscher, U; Le Grice, S F (2001). A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis. Journal of Biological Chemistry, 276(29):27721-27730.

Missura, M; Buterin, T; Hindges, R; Hübscher, U; Kaspárková, J; Brabec, V; Naegeli, H (2001). Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair. The EMBO Journal, 20(23):3554-3564.

Tasara, T; Hottiger, M O; Hübscher, U (2001). Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation. Biological Chemistry, 382(7):993-999.

Hasan, S; Stucki, M; Hassa, P O; Imhof, R; Gehrig, P; Hunziker, P; Hübscher, U; Hottiger, M O (2001). Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Molecular Cell, 7(6):1221-1231.

Maga, G; Frouin, I; Spadari, S; Hubscher, U (2001). Replication protein A as a "fidelity clamp" for DNA polymerase alpha. Journal of Biological Chemistry, 276(21):18235-18242.

Maga, G; Hübscher, U; Pregnolato, M; Ubiali, D; Gosselin, G; Spadari, S (2001). Potentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs. Antimicrobial Agents and Chemotherapy, 45(4):1192-1200.

Stucki, M; Jónsson, Z O; Hübscher, U (2001). In eukaryotic flap endonuclease 1, the C terminus is essential for substrate binding. Journal of Biological Chemistry, 276(11):7843-7849.

Hobi, R; Hübscher, U; Neftel, K; Alteri, E; Poncioni, B; Walker, M R; Woods-Cook, K; Schneider, P; Lazdins, J K (2001). Anti-HIV-1 activity in vitro of ceftazidime degradation products. Antiviral Chemistry & Chemotherapy, 12(2):109-118.

Stucki, M; Stagljar, I; Jónsson, Z O; Hübscher, U (2001). A coordinated interplay: proteins with multiple functions in DNA replication, DNA repair, cell cycle/checkpoint control, and transcription. Progress in Nucleic Acid Research and Molecular Biology, 65:261-298.

Rülicke, T; Hübscher, U (2000). Germ line transformation of mammals by pronuclear microinjection. Experimental Physiology, 85(6):859-601.

Henneke, G; Raffin, J P; Ferrari, E; Jónsson, Z O; Dietrich, J; Hübscher, U (2000). The PCNA from Thermococcus fumicolans functionally interacts with DNA polymerase delta. Biochemical and Biophysical Research Communications (BBRC), 276(2):600-6.

Koundrioukoff, S; Jónsson, Z O; Hasan, S; de Jong, R N; van der Vliet, P C; Hottiger, M O; Hübscher, U (2000). A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation. Journal of Biological Chemistry, 275(30):22882-22887.

Georlette, D; Jónsson, Z O; Van Petegem, F; Chessa, J; Van Beeumen, J; Hübscher, U; Gerday, C (2000). A DNA ligase from the psychrophile Pseudoalteromonas haloplanktis gives insights into the adaptation of proteins to low temperatures. FEBS Journal, 267(12):3502-3512.

Hübscher, U; Nasheuer, H P; Syväoja, J E (2000). Eukaryotic DNA polymerases, a growing family. Trends in Biochemical Sciences, 25(3):143-147.

Moggs, J G; Grandi, P; Quivy, J P; Jónsson, Z O; Hübscher, U; Becker, P B; Almouzni, G (2000). A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage. Molecular and Cellular Biology, 20(4):1206-1218.

Araújo, S J; Tirode, F; Coin, F; Pospiech, H; Syväoja, J E; Stucki, M; Hübscher, U; Egly, J M; Wood, R D (2000). Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK. Genes and Development, 14(3):349-359.

Maga, G; Stucki, M; Spadari, S; Hübscher, U (2000). DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. Journal of Molecular Biology, 295(4):801.

Mossi, R; Keller, R C; Ferrari, E; Hübscher, U (2000). DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase alpha at a critical length. Journal of Molecular Biology, 295(4):803-814.

Schumacher, S B; Stucki, M; Hübscher, U (2000). The N-terminal region of DNA polymerase delta catalytic subunit is necessary for holoenzyme function. Nucleic Acids Research, 28(2):620-625.

Pascucci, B; Stucki, M; Jónsson, Z O; Dogliotti, E; Hübscher, U (1999). Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon. Journal of Biological Chemistry, 274(47):33696-33702.

Keller, R C; Mossi, R; Maga, G; Wellinger, R E; Hübscher, U; Sogo, J M (1999). Electron microscopic analysis reveals that replication factor C is sequestered by single-stranded DNA. Nucleic Acids Research, 27(17):3433-3437.

Stagljar, I; Hübscher, U; Barberis, A (1999). Activation of DNA replication in yeast by recruitment of the RNA polymerase II transcription complex. Biological Chemistry, 380(5):525-30.

Maga, G; Amacker, M; Hübscher, U; Gosselin, G; Imbach, J L; Mathé, C; Faraj, A; Sommadossi, J P; Spadari, S (1999). Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs. Nucleic Acids Research, 27(4):972-978.

Tasara, T; Amacker, M; Hübscher, U (1999). Intramolecular chimeras of the p51 subunit between HIV-1 and FIV reverse transcriptases suggest a stabilizing function for the p66 subunit in the heterodimeric enzyme. Biochemistry, 35(5):1633-1642.

Marx, A; Spichty, M; Amacker, M; Schwitter, U; Hübscher, U; Bickle, T A; Maga, G; Giese, B (1999). Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides. Chemistry & Biology, 6(2):111-116.

Maga, G; Jónsson, Z O; Stucki, M; Spadari, S; Hübscher, U (1999). Dual mode of interaction of DNA polymerase epsilon with proliferating cell nuclear antigen in primer binding and DNA synthesis. Journal of Molecular Biology, 285(1):259-267.

Shivji, M K; Ferrari, E; Ball, K; Hübscher, U; Wood, R D (1998). Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1. Oncogene, 17(22):2827-2835.

Perderiset, M; Maga, G; Piard, K; Francesconi, S; Tratner, I; Hübscher, U; Baldacci, G (1998). Mutant DNA polymerase delta from thermosensitive Schizosaccharomyces pombe strains display reduced stimulation by proliferating cell nuclear antigen. Biochemical Journal, 335(3):581-588.

Marx, A; Amacker, M; Stucki, M; Hübscher, U; Bickle, T A; Giese, B (1998). 4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase. Nucleic Acids Research, 26(17):4063-4069.

Stucki, M; Pascucci, B; Parlanti, E; Fortini, P; Wilson, S H; Hübscher, U; Dogliotti, E (1998). Mammalian base excision repair by DNA polymerases delta and epsilon. Oncogene, 17(7):835-843.

Mossi, R; Ferrari, E; Hübscher, U (1998). DNA ligase I selectively affects DNA synthesis by DNA polymerases delta and epsilon suggesting differential functions in DNA replication and repair. Journal of Biological Chemistry, 273(23):14322-14330.

von Janta-Lipinski, M; Costisella, B; Ochs, H; Hübscher, U; Hafkemeyer, P; Matthes, E (1998). Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase. Journal of Medicinal Chemistry, 41(12):2040-2046.

Mossi, R; Hübscher, U (1998). Clamping down on clamps and clamp loaders--the eukaryotic replication factor C. FEBS Journal, 254(2):209-216.

Amacker, M; Hübscher, U (1998). Chimeric HIV-1 and feline immunodeficiency virus reverse transcriptases: critical role of the p51 subunit in the structural integrity of heterodimeric lentiviral DNA polymerases. Journal of Molecular Biology, 278(4):757-765.

Schurtenberger, P; Egelhaaf, S U; Hindges, R; Maga, G; Jónsson, Z O; May, R P; Glatter, O; Hübscher, U (1998). The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering. Journal of Molecular Biology, 275(1):123-132.

Maga, G; Amacker, M; Ruel, N; Hübscher, U; Spadari, S (1997). Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions. Journal of Molecular Biology, 274(5):738-747.

Jónsson, Z O; Hübscher, U (1997). Proliferating cell nuclear antigen: more than a clamp for DNA polymerases. BioEssays, 19(11):967-975.

Mossi, R; Jónsson, Z O; Allen, B L; Hardin, S H; Hübscher, U (1997). Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. Journal of Biological Chemistry, 272(3):1769-1776.

Jessberger, R; Schär, P; Robins, P; Ferrari, E; Riwar, B; Hübscher, U (1997). Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: up-regulation of DNA polymerase delta. Nucleic Acids Research, 25(2):289-296.

Lutz, M J; Held, H A; Hottiger, M O; Hübscher, U; Benner, S A (1996). Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet. Nucleic Acids Research, 24(7):1308-1313.

Amacker, M; Hottiger, M O; Hübscher, U (1995). Feline immunodeficiency virus reverse transcriptase: expression, functional characterization, and reconstitution of the 66- and 51-kilodalton subunits. Journal of Virology, 69(10):6273-6279.

Horlacher, J; Hottiger, M O; Podust, V N; Hübscher, U; Benner, S A (1995). Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 92(14):6329-6333.

Ziemienowicz, A; Zylicz, M; Floth, C; Hübscher, U (1995). Calf thymus Hsc70 protein protects and reactivates prokaryotic and eukaryotic enzymes. Journal of Biological Chemistry, 270(26):15479-15484.

Hoffmann, J S; Pillaire, M J; Maga, G; Podust, V N; Hübscher, U; Villani, G (1995). DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 92(12):5356-5360.

Hottiger, M O; Gramatikoff, K; Georgiev, O; Chaponnier, C; Schaffner, W; Hübscher, U (1995). The large subunit of HIV-1 reverse transcriptase interacts with beta-actin. Nucleic Acids Research, 23(5):736-741.

This list was generated on Fri Jun 21 23:51:35 2024 CEST.