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Targeting Beclin 1 for viral subversion of macroautophagy


Gannagé, M; Rämer, P C; Münz, C (2010). Targeting Beclin 1 for viral subversion of macroautophagy. Autophagy, 6(1):166-167.

Abstract

We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell. Here we discuss several viruses that now have been described to compromise macroautophagy via binding to Atg6/Beclin 1 with different outcomes for their replication, and how interaction with one and the same protein could inhibit autophagosome generation or degradation.

We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell. Here we discuss several viruses that now have been described to compromise macroautophagy via binding to Atg6/Beclin 1 with different outcomes for their replication, and how interaction with one and the same protein could inhibit autophagosome generation or degradation.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:2010
Deposited On:02 Feb 2011 15:50
Last Modified:05 Apr 2016 14:42
Publisher:Landes Bioscience
ISSN:1554-8627
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.4161/auto.6.1.10624
PubMed ID:20009549
Permanent URL: http://doi.org/10.5167/uzh-44294

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