Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-44294
Gannagé, M; Rämer, P C; Münz, C (2010). Targeting Beclin 1 for viral subversion of macroautophagy. Autophagy, 6(1):166-167.
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We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell. Here we discuss several viruses that now have been described to compromise macroautophagy via binding to Atg6/Beclin 1 with different outcomes for their replication, and how interaction with one and the same protein could inhibit autophagosome generation or degradation.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||02 Feb 2011 15:50|
|Last Modified:||23 Nov 2012 13:05|
|Free access at:||Publisher DOI. An embargo period may apply.|
Scopus®. Citation Count: 16
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