Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-982
Nellen, D; Burke, R; Struhl, G; Basler, K (1996). Direct and long-range action of a DPP morphogen gradient. Cell, 85(3):357-368.
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During development of the Drosophila wing, the decapentaplegic (dpp) gene is expressed in a stripe of cells along the anteroposterior compartment boundary and gives rise to a secreted protein that exerts a long-range organizing influence on both compartments. Using clones of cells that express DPP, or in which DPP receptor activity has been constitutively activated or abolished, we show that DPP acts directly and at long range on responding cells, rather than by proxy through the short-range induction of other signaling molecules. Further, we show that two genes, optomotor-blind and spalt are transcriptionally activated at different distances from DPP-secreting cells and provide evidence that these genes respond to different threshold concentrations of DPP protein. We propose that DPP acts as a gradient morphogen during wing development.
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|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Date:||3 May 1996|
|Deposited On:||11 Feb 2008 12:19|
|Last Modified:||05 Apr 2016 12:16|
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