Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation

Holst, Sebastian C; Sousek, Alexandra; Hefti, Katharina; Saberi-Moghadam, Sohrab; Buck, Alfred; Ametamey, Simon M; Scheidegger, Milan; Franken, Paul; Henning, Anke; Seifritz, Erich; Tafti, Mehdi; Landolt, Hans-Peter

doi:10.7554/eLife.28751

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Holst, S. C., Sousek, A., Hefti, K., Saberi-Moghadam, S., Buck, A., Ametamey, S. M., Scheidegger, M., Franken, P., Henning, A., Seifritz, E., Tafti, M., & Landolt, H.-P. (2017). Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation. ELife, 6, e28751. https://doi.org/10.7554/eLife.28751

Abstract

Increased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive. We here demonstrate that metabotropic glutamate receptors of subtype 5 (mGluR5) contribute to the molecular machinery governing sleep-wake homeostasis. Using positron emission tomography, magnetic resonance spectroscopy, and electroencephalography in humans, we find that increased mGluR5 availability after sleep loss t