Publication: Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1
Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1
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Althoff, F., Karess, R. E., & Lehner, C. F. (2012). Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1. Molecular Biology of the Cell, 23(12), 2275–2291. https://doi.org/10.1091/mbc.E12-02-0117
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Monopolar spindle 1 (Mps1) is essential for the spindle assembly checkpoint (SAC), which prevents anaphase onset in the presence of misaligned chromosomes. Moreover, Mps1 kinase contributes in a SAC-independent manner to the correction of erroneous initial attachments of chromosomes to the spindle. Our characterization of the Drosophila homologue reveals yet another SAC-independent role. As in yeast, modest overexpression of Drosophila Mps1 is sufficient to delay progression through mitosis during metaphase, even though chromosome con
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- Althoff, F
- Karess, R E
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Althoff, F., Karess, R. E., & Lehner, C. F. (2012). Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1. Molecular Biology of the Cell, 23(12), 2275–2291. https://doi.org/10.1091/mbc.E12-02-0117
