Publication: Light-Induced Synthesis and Radiotheranostic Treatment of Gastric Cancer with $^161$Tb-Labeled Monoclonal Antibodies
Light-Induced Synthesis and Radiotheranostic Treatment of Gastric Cancer with $^161$Tb-Labeled Monoclonal Antibodies
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Cieslik, P. A., Roth, D., Nisli, E., Genz, J., Berton, C., Grundler, P. V., Hillhouse, C. C., Moiseeva, A. N., Nolff, M. C., Braband, H., Van Der Meulen, N., & Holland, J. P. (2025). Light-Induced Synthesis and Radiotheranostic Treatment of Gastric Cancer with $^161$Tb-Labeled Monoclonal Antibodies. JACS Au, 5(6), 2606–2618. https://doi.org/10.1021/jacsau.5c00219
Abstract
Abstract
Abstract
Radiolabeled monoclonal antibodies (mAbs) form a major branch of nuclear medicine and are used in the development of tracers for both diagnostic imaging and molecularly targeted radio-(immuno)-therapy (RIT). Since treatment options for many types of late-stage cancers are limited and these diseases become refractory to classic chemotherapy, new tools are required to improve patient outcomes. The high tumor uptake and specificity of mAbs, coupled with increased therapeutic range of energetic β-emitting radionuclides, offers a potential
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Creators (Authors)
- Cieslik, Patrick A.
- Roth, Dominik
- Nisli, Eda
- Genz, Jonas
- Berton, Cesare
- Grundler, Pascal V
- Hillhouse, Colin C
- Moiseeva, Anzhelika N
- Braband, Henrik
- Holland, Jason P
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Cieslik, P. A., Roth, D., Nisli, E., Genz, J., Berton, C., Grundler, P. V., Hillhouse, C. C., Moiseeva, A. N., Nolff, M. C., Braband, H., Van Der Meulen, N., & Holland, J. P. (2025). Light-Induced Synthesis and Radiotheranostic Treatment of Gastric Cancer with $^161$Tb-Labeled Monoclonal Antibodies. JACS Au, 5(6), 2606–2618. https://doi.org/10.1021/jacsau.5c00219
