Publication: Oxomer Formation by the Oxygen Sensors PHD1-3 and FIH
Oxomer Formation by the Oxygen Sensors PHD1-3 and FIH
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Jucht, A. (2024). Oxomer Formation by the Oxygen Sensors PHD1-3 and FIH. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-259622
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The regulation of the response to limited oxygen levels (hypoxia) is crucial for metazoan survival and is primarily governed by the transcription factor hypoxia-inducible factor (HIF). HIF consists of HIF-α and HIF-β subunits. The HIF pathway, regulated by prolyl hydroxylase (PHD) proteins and factor inhibiting HIF (FIH), plays a pivotal role in oxygen-dependent signalling, primarily through hydroxylation of specific proline and asparagine residues on HIF- α, modulating its stability and transcriptional activity. While hypoxia-induced
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Jucht, A. (2024). Oxomer Formation by the Oxygen Sensors PHD1-3 and FIH. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-259622
