Publication: Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor
Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor
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Santoro, M. M., Penengo, L., Minetto, M., Orecchia, S., Cilli, M., & Gaudino, G. (1998). Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor. Oncogene, 17, 741–749. https://doi.org/10.1038/sj.onc.1201994
Abstract
Abstract
Abstract
Ron (the receptor for Macrophage Stimulating Protein) has never been implicated before in human malignancies or in cell transformation. In this report we show that Ron can acquire oncogenic potential by means of two amino acid substitutions-D1232V and M1254T-affecting highly conserved residues in the tyrosine kinase domain. The same mutations in Kit and Ret have been found associated with two human malignancies, mastocytosis and Multiple Endocrine Neoplasia type 2B (MEN2B), respectively. Both mutations caused Ron-mediated transformati
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Creators (Authors)
- Santoro, M M
- Penengo, Lorenza
- Minetto, M
- Orecchia, S
- Cilli, M
- Gaudino, G
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Citations
Santoro, M. M., Penengo, L., Minetto, M., Orecchia, S., Cilli, M., & Gaudino, G. (1998). Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor. Oncogene, 17, 741–749. https://doi.org/10.1038/sj.onc.1201994
