Publication: SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells
SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells
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Nuvolone, M., Kana, V., Hutter, G., Sakata, D., Mortin-Toth, S. M., Russo, G., Danska, J. S., & Aguzzi, A. (2013). SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells. Journal of Experimental Medicine, 210(12), 2539–2552. https://doi.org/10.1084/jem.20131274
Abstract
Abstract
Abstract
Prnp(-/-) mice lack the prion protein PrP(C) and are resistant to prion infections, but variable phenotypes have been reported in Prnp(-/-) mice and the physiological function of PrP(C) remains poorly understood. Here we examined a cell-autonomous phenotype, inhibition of macrophage phagocytosis of apoptotic cells, previously reported in Prnp(-/-) mice. Using formal genetic, genomic, and immunological analyses, we found that the regulation of phagocytosis previously ascribed to PrP(C) is instead controlled by a linked locus encoding t
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Creators (Authors)
- Nuvolone, Mario
- Kana, Veronika
- Hutter, Gregor
- Sakata, Daiji
- Mortin-Toth, Steven M
- Russo, Giancarlo
- Danska, Jayne S
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Citations
Nuvolone, M., Kana, V., Hutter, G., Sakata, D., Mortin-Toth, S. M., Russo, G., Danska, J. S., & Aguzzi, A. (2013). SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells. Journal of Experimental Medicine, 210(12), 2539–2552. https://doi.org/10.1084/jem.20131274
