Publication: H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability
H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability
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Duzanic, F., Mohana-Natarajan, V., Fisicaro, S., Bakker, C., Aouami, M., Amaral, G., Lopes, M., Taneja, N., & Penengo, L. (2025). H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability. The EMBO Journal, 44(22), 6598–6625. https://doi.org/10.1038/s44318-025-00602-1
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Ubiquitination of the C-terminus of histone H2B (H2BK120ub) is a key histone modification with functions in a wide array of DNA-related processes, best characterized in gene transcription and repair. A role for H2B ubiquitination in DNA replication has been postulated and investigated in yeast but is still elusive in human cells. Here, we uncovered a critical function of H2BK120ub in replication fork dynamics. H2BK120ub is present at replication forks and accumulates upon replication stress in a manner dependent on ATR and RAD51. Loss
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Duzanic, F., Mohana-Natarajan, V., Fisicaro, S., Bakker, C., Aouami, M., Amaral, G., Lopes, M., Taneja, N., & Penengo, L. (2025). H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability. The EMBO Journal, 44(22), 6598–6625. https://doi.org/10.1038/s44318-025-00602-1
