Publication: The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells
The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells
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Haag, A., Walser, M., Henggeler, A., & Hajnal, A. (2020). The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells. ELife, 9, e50986. https://doi.org/10.7554/eLife.50986
Abstract
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Abstract
The intracellular trafficking of growth factor receptors determines the activity of their downstream signaling pathways. Here, we show that the putative HSP-90 co-chaperone CHP-1 acts as a regulator of EGFR trafficking in C. elegans. Loss of chp-1 causes the retention of the EGFR in the ER and decreases MAPK signaling. CHP-1 is specifically required for EGFR trafficking, as the localization of other transmembrane receptors is unaltered in chp-1(lf) mutants, and the inhibition of hsp-90 or other co-chaperones does not affect EGFR local
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- Haag, Andrea
- Henggeler, Adrian
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Citations
Haag, A., Walser, M., Henggeler, A., & Hajnal, A. (2020). The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells. ELife, 9, e50986. https://doi.org/10.7554/eLife.50986
