Psychiatric symptoms and expression of glucocorticoid receptor gene in cocaine users: A longitudinal study

Kluwe-Schiavon, B; Schote, A B; Vonmoos, M; Hulka, L M; Preller, K H; Meyer, J; Baumgartner, M R; Grünblatt, E; Quednow, Boris B

doi:10.5167/uzh-178427

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Kluwe-Schiavon, B., Schote, A. B., Vonmoos, M., Hulka, L. M., Preller, K. H., Meyer, J., Baumgartner, M. R., Grünblatt, E., & Quednow, B. B. (2020). Psychiatric symptoms and expression of glucocorticoid receptor gene in cocaine users: A longitudinal study. Journal of Psychiatric Research, 121, 126–134. https://doi.org/10.1016/j.jpsychires.2019.11.017

Abstract

Background Chronic cocaine users (CU) display reduced peripheral expression of the glucocorticoid receptor gene (NR3C1), which is potentially involved in stress-related psychiatric symptoms frequently occurring in CU. However, it is unknown whether psychiatric symptoms and lower NR3C1 expression are related to each other and whether reduction of drug consumption reverse them. Method At baseline, NR3C1 mRNA expression was measured in 68 recreational CU, 30 dependent CU, and 68 stimulant-naïve controls. Additionally, the Revised Symptom