Publication: The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
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Franklin, B. S., Bossaller, L., De Nardo, D., Ratter, J. M., Stutz, A., Engels, G., Brenker, C., Nordhoff, M., Mirandola, S. R., Al-Amoudi, A., Mangan, M. S., Zimmer, S., Monks, B. G., Fricke, M., Schmidt, R. E., Espevik, T., Jones, B., Jarnicki, A. G., Hansbro, P. M., … Latz, E. (2014). The adaptor ASC has extracellular and “prionoid” activities that propagate inflammation. Nature Immunology, 15(8), 727–737. https://doi.org/10.1038/ni.2913
Abstract
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Microbes or danger signals trigger inflammasome sensors, which induce polymerization of the adaptor ASC and the assembly of ASC specks. ASC specks recruit and activate caspase-1, which induces maturation of the cytokine interleukin 1β (IL-1β) and pyroptotic cell death. Here we found that after pyroptosis, ASC specks accumulated in the extracellular space, where they promoted further maturation of IL-1β. In addition, phagocytosis of ASC specks by macrophages induced lysosomal damage and nucleation of soluble ASC, as well as activation
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Creators (Authors)
- Franklin, Bernardo S
- Bossaller, Lukas
- De Nardo, Dominic
- Ratter, Jacqueline M
- Stutz, Andrea
- Engels, Gudrun
- Brenker, Christoph
- Nordhoff, Mark
- Mirandola, Sandra R
- Al-Amoudi, Ashraf
- Mangan, Matthew S
- Zimmer, Sebastian
- Monks, Brian G
- Fricke, Martin
- Schmidt, Reinhold E
- Espevik, Terje
- Jones, Bernadette
- Jarnicki, Andrew G
- Hansbro, Philip M
- Busto, Patricia
- Marshak-Rothstein, Ann
- Hornemann, Simone
- Kastenmüller, Wolfgang
- Latz, Eicke
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Franklin, B. S., Bossaller, L., De Nardo, D., Ratter, J. M., Stutz, A., Engels, G., Brenker, C., Nordhoff, M., Mirandola, S. R., Al-Amoudi, A., Mangan, M. S., Zimmer, S., Monks, B. G., Fricke, M., Schmidt, R. E., Espevik, T., Jones, B., Jarnicki, A. G., Hansbro, P. M., … Latz, E. (2014). The adaptor ASC has extracellular and “prionoid” activities that propagate inflammation. Nature Immunology, 15(8), 727–737. https://doi.org/10.1038/ni.2913
