Publication: RNF168 promotes noncanonical K27 ubiquitination to signal DNA damage
RNF168 promotes noncanonical K27 ubiquitination to signal DNA damage
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Gatti, M., Pinato, S., Maiolica, A., Rocchio, F., Prato, M. G., Aebersold, R., & Penengo, L. (2015). RNF168 promotes noncanonical K27 ubiquitination to signal DNA damage. Cell Reports, 10(2), 226–238. https://doi.org/10.1016/j.celrep.2014.12.021
Abstract
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Abstract
Ubiquitination regulates numerous cellular processes by generating a versatile communication system based on eight structurally and functionally different chains linked through distinct residues. Except for K48 and K63, the biological relevance of different linkages is largely unclear. Here, we show that RNF168 ubiquitin ligase promotes noncanonical K27-linked ubiquitination both in vivo and in vitro. We demonstrate that residue K27 of ubiquitin (UbK27) is required for RNF168-dependent chromatin ubiquitination, by targeting histones H
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Creators (Authors)
- Gatti, Marco
- Pinato, Sabrina
- Maiolica, Alessio
- Rocchio, Francesca
- Prato, Maria Giulia
- Aebersold, Ruedi
- Penengo, Lorenza
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Citations
Gatti, M., Pinato, S., Maiolica, A., Rocchio, F., Prato, M. G., Aebersold, R., & Penengo, L. (2015). RNF168 promotes noncanonical K27 ubiquitination to signal DNA damage. Cell Reports, 10(2), 226–238. https://doi.org/10.1016/j.celrep.2014.12.021
