Publication: Changes in NAD and lipid metabolism drive acidosis-induced acute kidney injury
Changes in NAD and lipid metabolism drive acidosis-induced acute kidney injury
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Bugarski, M., Ghazi, S., Polesel, M., Martins, J. R., & Hall, A. M. (2021). Changes in NAD and lipid metabolism drive acidosis-induced acute kidney injury. Journal of the American Society of Nephrology (JASN), 32, 342–356. https://doi.org/10.1681/ASN.2020071003
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BACKGROUND: The kidney plays an important role in maintaining normal blood pH. Metabolic acidosis (MA) upregulates the pathway that mitochondria in the proximal tubule (PT) use to produce ammonia and bicarbonate from glutamine, and is associated with AKI. However, the extent to which MA causes AKI, and thus whether treating MA would be beneficial, is unclear. METHODS: Gavage with ammonium chloride induced acute MA. Multiphoton imaging of mitochondria (NADH/membrane potential) and transport function (dextran/albumin uptake), oxygen con
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Bugarski, M., Ghazi, S., Polesel, M., Martins, J. R., & Hall, A. M. (2021). Changes in NAD and lipid metabolism drive acidosis-induced acute kidney injury. Journal of the American Society of Nephrology (JASN), 32, 342–356. https://doi.org/10.1681/ASN.2020071003
