Publication: Vascular abnormalities, paraoxonase activity, and dysfunctional HDL in primary antiphospholipid syndrome
Vascular abnormalities, paraoxonase activity, and dysfunctional HDL in primary antiphospholipid syndrome
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Charakida, M., Besler, C., Batuca, J. R., Sangle, S., Marques, S., Sousa, M., Wang, G., Tousoulis, D., Delgado Alves, J., Loukogeorgakis, S. P., Mackworth-Young, C., D’Cruz, D., Luscher, T., Landmesser, U., & Deanfield, J. E. (2009). Vascular abnormalities, paraoxonase activity, and dysfunctional HDL in primary antiphospholipid syndrome. JAMA: The Journal of the American Medical Association, 302, 1210–1217. https://doi.org/10.1001/jama.2009.1346
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CONTEXT: Accelerated atherosclerosis has been described in antiphospholipid syndrome, but the vascular abnormalities and the underlying mechanisms remain unclear. OBJECTIVES: To compare vascular structure and function in patients with positive antiphospholipid antibodies (aPL) with controls and to assess their relationship with paraoxonase activity. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study of 77 women with positive antiphospholipid antibodies from a lupus outpatient clinic in London, England (90% of the eligible popu
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Charakida, M., Besler, C., Batuca, J. R., Sangle, S., Marques, S., Sousa, M., Wang, G., Tousoulis, D., Delgado Alves, J., Loukogeorgakis, S. P., Mackworth-Young, C., D’Cruz, D., Luscher, T., Landmesser, U., & Deanfield, J. E. (2009). Vascular abnormalities, paraoxonase activity, and dysfunctional HDL in primary antiphospholipid syndrome. JAMA: The Journal of the American Medical Association, 302, 1210–1217. https://doi.org/10.1001/jama.2009.1346