PaxDb, a database of protein abundance averages across all three domains of life

Abstract

Although protein expression is regulated both temporally and spatially, most proteins have an intrinsic, typical range of functionally effective abundance levels. These extend from a few molecules per cell for signaling proteins, to millions of molecules for structural proteins. When addressing fundamental questions related to protein evolution, translation and folding, but also in routine laboratory work, a simple rough estimate of the average wild type abundance of each detectable protein in an organism is often desirable. Here, we Show more