Publication: Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance
Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance
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Galimov, A., Hartung, A., Trepp, R., Mader, A., Flück, M., Linke, A., Blüher, M., Christ, E., & Krützfeldt, J. (2015). Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance. Journal of Molecular Medicine, 93(12), 1369–1379. https://doi.org/10.1007/s00109-015-1322-y
Abstract
Abstract
Abstract
Replacement of growth hormone (GH) in patients suffering from GH deficiency (GHD) offers clinical benefits on body composition, exercise capacity, and skeletal integrity. However, GH replacement therapy (GHRT) is also associated with insulin resistance, but the mechanisms are incompletely understood. We demonstrate that in GH-deficient mice (growth hormone-releasing hormone receptor (Ghrhr)lit/lit), insulin resistance after GHRT involves the upregulation of the extracellular matrix (ECM) and the downregulation of microRNA miR-29a in s
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Creators (Authors)
- Galimov, Artur
- Hartung, Angelika
- Trepp, Roman
- Mader, Alexander
- Flück, Martin
- Linke, Axel
- Blüher, Matthias
- Christ, Emanuel
- Krützfeldt, Jan
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Citations
Galimov, A., Hartung, A., Trepp, R., Mader, A., Flück, M., Linke, A., Blüher, M., Christ, E., & Krützfeldt, J. (2015). Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance. Journal of Molecular Medicine, 93(12), 1369–1379. https://doi.org/10.1007/s00109-015-1322-y
