Publication: Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance
Date
Date
Date
2015
Journal Article
Published version
Abstract
Abstract
Abstract
Replacement of growth hormone (GH) in patients suffering from GH deficiency (GHD) offers clinical benefits on body composition, exercise capacity, and skeletal integrity. However, GH replacement therapy (GHRT) is also associated with insulin resistance, but the mechanisms are incompletely understood. We demonstrate that in GH-deficient mice (growth hormone-releasing hormone receptor (Ghrhr)lit/lit), insulin resistance after GHRT involves the upregulation of the extracellular matrix (ECM) and the downregulation of microRNA miR-29a in s
Additional indexing
Creators (Authors)
- Galimov, Artur
- Hartung, Angelika
- Trepp, Roman
- Mader, Alexander
- Flück, Martin
- Linke, Axel
- Blüher, Matthias
- Christ, Emanuel
- Krützfeldt, Jan
Volume
Volume
Volume
93
Number
Number
Number
12
Page range/Item number
Page range/Item number
Page range/Item number
1369
Page end
Page end
Page end
1379
Item Type
Item Type
Item Type
Journal Article
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2015-07-23
Date available
Date available
Date available
2015-08-06
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
0946-2716
OA Status
OA Status
OA Status
Hybrid
Free Access at
Free Access at
Free Access at
Pubmed ID
Publisher DOI
Hybrid Open Access
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