Publication: Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity
Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity
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Liao, W.-H., Suendermann, C., Steuer, A. E., Pacheco Lopez, G., Odermatt, A., Faresse, N., Henneberg, M., & Langhans, W. (2018). Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity. Journal of Clinical Investigation Insight, 3(14), e99015. https://doi.org/10.1172/jci.insight.99015
Abstract
Abstract
Abstract
Aldosterone synthase inhibitors (ASIs) should alleviate obesity-related cardiovascular and renal problems resulting partly from aldosterone excess, but their clinical use may have limitations. To improve knowledge for the use of ASIs, we investigated physiology in aldosterone synthase-knockout (ASKO) mice. On regular chow diet (CD), ASKO mice ate more and weighed less than WT mice, largely because they hyperventilated to eliminate acid as CO2. Replacing CD with high-fat diet (HFD) lessened the respiratory burden in ASKO mice, as did 1
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Creators (Authors)
- Liao, Wan-Hui
- Suendermann, Claudia
- Steuer, Andrea Eva
- Pacheco Lopez, Gustavo
- Odermatt, Alex
- Faresse, Nourdine
- Henneberg, Maciej
- Langhans, Wolfgang
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Citations
Liao, W.-H., Suendermann, C., Steuer, A. E., Pacheco Lopez, G., Odermatt, A., Faresse, N., Henneberg, M., & Langhans, W. (2018). Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity. Journal of Clinical Investigation Insight, 3(14), e99015. https://doi.org/10.1172/jci.insight.99015
