Publication: Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival, engraftment, and distribution by hybrid single photon emission computed tomography/computed tomography of sodium iodide symporter transgene expression
Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival, engraftment, and distribution by hybrid single photon emission computed tomography/computed tomography of sodium iodide symporter transgene expression
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Templin, C., Zweigerdt, R., Schwanke, K., Olmer, R., Ghadri, J.-R., Emmert, M. Y., Müller, E., Küest, S. M., Cohrs, S., Schibli, R., Kronen, P. W., Hilbe, M., Reinisch, A., Strunk, D., Haverich, A., Hoerstrup, S., Lüscher, T. F., Kaufmann, P. A., Landmesser, U., & Martin, U. (2012). Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival, engraftment, and distribution by hybrid single photon emission computed tomography/computed tomography of sodium iodide symporter transgene expression. Circulation, 126(4), 430–439. https://doi.org/10.1161/CIRCULATIONAHA.111.087684
Abstract
Abstract
Abstract
BACKGROUND: Evaluation of novel cellular therapies in large-animal models and patients is currently hampered by the lack of imaging approaches that allow for long-term monitoring of viable transplanted cells. In this study, sodium iodide symporter (NIS) transgene imaging was evaluated as an approach to follow in vivo survival, engraftment, and distribution of human-induced pluripotent stem cell (hiPSC) derivatives in a pig model of myocardial infarction.
METHODS AND RESULTS: Transgenic hiPSC lines stably expressing a fluorescent repo
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Creators (Authors)
- Templin, Christian
- Zweigerdt, Robert
- Schwanke, Kristin
- Olmer, Ruth
- Cohrs, Susan
- Schibli, Roger
- Hilbe, Monika
- Reinisch, Andreas
- Strunk, Dirk
- Haverich, Axel
- Lüscher, Thomas F
- Landmesser, Ulf
- Martin, Ulrich
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Templin, C., Zweigerdt, R., Schwanke, K., Olmer, R., Ghadri, J.-R., Emmert, M. Y., Müller, E., Küest, S. M., Cohrs, S., Schibli, R., Kronen, P. W., Hilbe, M., Reinisch, A., Strunk, D., Haverich, A., Hoerstrup, S., Lüscher, T. F., Kaufmann, P. A., Landmesser, U., & Martin, U. (2012). Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival, engraftment, and distribution by hybrid single photon emission computed tomography/computed tomography of sodium iodide symporter transgene expression. Circulation, 126(4), 430–439. https://doi.org/10.1161/CIRCULATIONAHA.111.087684
