Publication: Sensitive multicolor indicators for monitoring norepinephrine in vivo
Sensitive multicolor indicators for monitoring norepinephrine in vivo
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Kagiampaki, Z., Rohner, V., Kiss, C., Curreli, S., Dieter, A., Wilhelm, M., Harada, M., Duss, S. N., Dernic, J., Bhat, M. A., Zhou, X., Ravotto, L., Ziebarth, T., Wasielewski, L. M., Sönmez, L., Benke, D., Weber, B., Bohacek, J., Reiner, A., … Patriarchi, T. (2023). Sensitive multicolor indicators for monitoring norepinephrine in vivo. Nature Methods, 20(9), 1426–1436. https://doi.org/10.1038/s41592-023-01959-z
Abstract
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Abstract
Genetically encoded indicators engineered from G-protein-coupled receptors are important tools that enable high-resolution in vivo neuromodulator imaging. Here, we introduce a family of sensitive multicolor norepinephrine (NE) indicators, which includes nLightG (green) and nLightR (red). These tools report endogenous NE release in vitro, ex vivo and in vivo with improved sensitivity, ligand selectivity and kinetics, as well as a distinct pharmacological profile compared with previous state-of-the-art GRAB$_{NE}$ indicators. Using in v
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Creators (Authors)
- Kagiampaki, Zacharoula
- Rohner, Valentin
- Kiss, Cedric
- Curreli, Sebastiano
- Dieter, Alexander
- Wilhelm, Maria
- Harada, Masaya
- Duss, Sian N
- Dernic, Jan
- Bhat, Musadiq A
- Zhou, Xuehan
- Ravotto, Luca
- Ziebarth, Tim
- Wasielewski, Laura Moreno
- Sönmez, Latife
- Benke, Dietmar
- Weber, Bruno
- Bohacek, Johannes
- Reiner, Andreas
- Wiegert, J Simon
- Fellin, Tommaso
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Citations
Kagiampaki, Z., Rohner, V., Kiss, C., Curreli, S., Dieter, A., Wilhelm, M., Harada, M., Duss, S. N., Dernic, J., Bhat, M. A., Zhou, X., Ravotto, L., Ziebarth, T., Wasielewski, L. M., Sönmez, L., Benke, D., Weber, B., Bohacek, J., Reiner, A., … Patriarchi, T. (2023). Sensitive multicolor indicators for monitoring norepinephrine in vivo. Nature Methods, 20(9), 1426–1436. https://doi.org/10.1038/s41592-023-01959-z
