Publication: N-Heterocyclic Carbene–Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy
N-Heterocyclic Carbene–Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy
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Chekkat, N., Dahm, G., Chardon, E., Wantz, M., Sitz, J., Decossas, M., Lambert, O., Frisch, B., Rubbiani, R., Gasser, G., Guichard, G., Fournel, S., & Bellemin-Laponnaz, S. (2016). N-Heterocyclic Carbene–Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy. Bioconjugate Chemistry, 27(8), 1942–1948. https://doi.org/10.1021/acs.bioconjchem.6b00320
Abstract
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The current interest for platinum N-heterocyclic carbene complexes in cancer research stems from their impressive toxicity reported against a range of different human cancer cells. To date, the demonstration of their in vivo efficacy relative to that of established platinum-based drugs has not been specifically addressed. Here, we introduce an innovative approach to increase the NHC-Pt complex potency whereby multiple NHC-Pt(II) complexes are coordinated along a polyethylenimine polymer (PEI) chain. We show that such NHC-Pt(II)-PEI co
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- Chekkat, Neila
- Dahm, Georges
- Chardon, Edith
- Wantz, May
- Sitz, Justine
- Decossas, Marion
- Lambert, Olivier
- Frisch, Benoit
- Rubbiani, Riccardo
- Gasser, Gilles
- Guichard, Gilles
- Fournel, Sylvie
- Bellemin-Laponnaz, Stéphane
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Chekkat, N., Dahm, G., Chardon, E., Wantz, M., Sitz, J., Decossas, M., Lambert, O., Frisch, B., Rubbiani, R., Gasser, G., Guichard, G., Fournel, S., & Bellemin-Laponnaz, S. (2016). N-Heterocyclic Carbene–Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy. Bioconjugate Chemistry, 27(8), 1942–1948. https://doi.org/10.1021/acs.bioconjchem.6b00320